55 results about "Prostate cancer cell line" patented technology

The present disclosure, in part, is directed to a mammalian prostate cancer cell line comprising at least one or a set of primary mammalian epithelial cells which have been infected with a retroviral vector carrying an oncogene selected from the group consisting of c-Myc, Ha-Ras, NeuT, c-Src and combinations thereof and in which said gene is expressed. Applications of the pro-state cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for developing metastasis, a method of preventing cancer or inhibiting metastasis of cancer susceptible to treatment in a subject at risk for developing cancer or metastasis of cancer, and method of identifying a candidate compound that selectively interferes with proliferation or viability of a cancer cell that has elevated levels of CCR5 and / or of at least one of its ligands.

The invention discloses aromatic ring / aromatic heterocycle-triazole-methylene-TCP derivatives, which have the structure described in general formula I: have significant biological inhibitory activity on LSD1, can be used to prepare drugs for inhibiting LSD1, and enrich the The types of TCP derivatives have laid the foundation for the development of new LSD1 inhibitors. Especially for the preparation of antitumor drugs, it has a certain degree of antitumor effect on gastric cancer cell lines (MGC‑803, SGC‑7901), breast cancer cell lines (MCF‑7), prostate cancer cell lines (PC‑3) and other tumor cell lines Inhibition of anti-tumor activity, provides a lead compound structure for anti-cancer drugs, and has a good application prospect. The present invention also provides the preparation method of the above-mentioned aromatic ring / aromatic heterocyclic-triazole-methylene-TCP derivative, with (1R, 2S)-phenylcyclopropylamine or (1R, 2S)-3,4 ‑Difluorophenylcyclopropylamine is used as a raw material, which is prepared by alkyne up-cycling and cycloaddition reaction. The preparation method is simple, and it is convenient for batch production and commercial application.