55 results about "Prostate cancer cell line" patented technology

The present invention relates to the synthesis of a series of ionone and curcumin derivatives as multi-targeting agents effective against both hormone-sensitive and hormone-independent cancers. In particular, the present invention is directed to a distinct class of bifunctional antiandrogens, which inhibit both AR and IKBkinases (IKK). A series of ionone-based chalcones were synthesized and their in vitro cytotoxicity against prostate cancer cell lines were demonstrated. A series of derivatives formed by reacting ionone-based chalcones and hydrazines demonstrate substantial antiproliferative activities in prostate cancer, breast cancer and lung cancer cell lines.

Oligoamine compounds with anti-cancer and anti-proliferative activity are provided, as well as methods for making and using the compounds. The compounds are shown to be active against prostate cancer cell lines and against prostate cancer tumors in mice. The compounds are also useful in treatment of breast cancer and other cancers.

The present disclosure, in part, is directed to a mammalian prostate cancer cell line comprising at least one or a set of primary mammalian epithelial cells which have been infected with a retroviral vector carrying an oncogene selected from the group consisting of c-Myc, Ha-Ras, NeuT, c-Src and combinations thereof and in which said gene is expressed. Applications of the pro-state cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for developing metastasis, a method of preventing cancer or inhibiting metastasis of cancer susceptible to treatment in a subject at risk for developing cancer or metastasis of cancer, and method of identifying a candidate compound that selectively interferes with proliferation or viability of a cancer cell that has elevated levels of CCR5 and / or of at least one of its ligands.

Castrate resistant prostate cancer cell lines exhibiting resistance to the androgen-receptor antagonist enzaluatamide overexpress one or both of IGFBP-2 or IGFBP-5 when compared to non-resistant cell lines. Oligonucleotides that target IGFBP-2 and IGFBP-5 can be used to overcome this resistance or as part of a treatment program when administered concurrently with the administration of androgen-receptor antagonist treatments.

The invention discloses aromatic ring / aromatic heterocycle-triazole-methylene-TCP derivatives, which have the structure described in general formula I: have significant biological inhibitory activity on LSD1, can be used to prepare drugs for inhibiting LSD1, and enrich the The types of TCP derivatives have laid the foundation for the development of new LSD1 inhibitors. Especially for the preparation of antitumor drugs, it has a certain degree of antitumor effect on gastric cancer cell lines (MGC‑803, SGC‑7901), breast cancer cell lines (MCF‑7), prostate cancer cell lines (PC‑3) and other tumor cell lines Inhibition of anti-tumor activity, provides a lead compound structure for anti-cancer drugs, and has a good application prospect. The present invention also provides the preparation method of the above-mentioned aromatic ring / aromatic heterocyclic-triazole-methylene-TCP derivative, with (1R, 2S)-phenylcyclopropylamine or (1R, 2S)-3,4 ‑Difluorophenylcyclopropylamine is used as a raw material, which is prepared by alkyne up-cycling and cycloaddition reaction. The preparation method is simple, and it is convenient for batch production and commercial application.

The present invention discloses a class of oleandrin derivatives represented by the following general formula I, and a preparation method, pharmaceutical composition and application thereof. The oleandrin derivatives have inhibitory activity on various human tumor cell lines, such as cervical cancer cell lines, leukemia cell lines, liver cancer cell lines and prostate cancer cell lines, and can be used as drugs for treating malignant tumors. In addition, the water solubility of the oleandrin derivative of the present invention is remarkably improved relative to that of oleandrin.