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Prostate cancer cell line, gene signatures and uses thereof

A technology for prostate cancer, cancer cells, in the field of cells and transgenic non-human animals

Inactive Publication Date: 2014-11-26
理查德 G 佩斯泰尔
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most patients undergoing androgen antagonist therapy subsequently relapse

Method used

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  • Prostate cancer cell line, gene signatures and uses thereof
  • Prostate cancer cell line, gene signatures and uses thereof
  • Prostate cancer cell line, gene signatures and uses thereof

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[0112] Mice, cell cultures, chemicals and reagents.

[0113] Experimental procedures using transgenic mice were approved by the ethics committee of Thomas Jefferson University. Mice are of the FVB strain. Mouse prostate epithelial cell cultures were isolated from the prostate of 12-week-old male mice and maintained as previously described [42] and analyzed after 25 passages with at least three lines for each genotype. Cell transduction with retroviral expression vectors encoding c-Myc, Ha-Ras, v-Src, NeuT in the vector pBABE-IRES-GFP was previously described [43,44].

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Abstract

The present disclosure, in part, is directed to a mammalian prostate cancer cell line comprising at least one or a set of primary mammalian epithelial cells which have been infected with a retroviral vector carrying an oncogene selected from the group consisting of c-Myc, Ha-Ras, NeuT, c-Src and combinations thereof and in which said gene is expressed. Applications of the pro-state cell lines, including immune competent animal models of prostate cancer, a method for the in vitro production of immortalized primary mammalian epithelial cells, a method of determining whether a human subject having prostate cancer is suffering from or at risk for developing metastasis, a method of preventing cancer or inhibiting metastasis of cancer susceptible to treatment in a subject at risk for developing cancer or metastasis of cancer, and method of identifying a candidate compound that selectively interferes with proliferation or viability of a cancer cell that has elevated levels of CCR5 and / or of at least one of its ligands.

Description

technical field [0001] Methods and compositions for diagnosing and treating cancer, including prostate cancer, are provided. Particular aspects of the invention relate to methods and compositions useful for prostate cancer diagnosis, research, treatment stratification, and treatment. Also provided in the invention are cells and transgenic non-human animals that can be used in these methods. [0002] Statement Regarding Federally Sponsored Research and Development [0003] This invention was made with Government support under Grant Nos. R01CA70896, R01CA75503, R01CA86072, P30CA56036, and R01CA132115-02 awarded by the National Institutes of Health (NIH). The government has certain rights in this invention. Background technique [0004] Cancer is a major health problem throughout the world. Despite advances in cancer detection and treatment, vaccines or other generally successful methods for prevention and / or treatment are not currently available. Current therapies, gener...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/87
CPCA01K67/0275G01N33/574C12Q1/6886A61K31/46C12N5/0693A61K31/506A61P35/00A61P35/04A61P43/00
Inventor 理查德·G·佩斯泰尔
Owner 理查德 G 佩斯泰尔
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