The invention discloses a method based on a
gene /
protein as a
diagnostic marker and a therapeutic target for
biliary atresia and application thereof. Notch3 signaling pathway and remodeling of hepaticartery
system mediated thereby are first proposed in the context of
biliary atresia (BA), and constitute a perfection to the existing theoretical mechanism. The Notch3-Hey1
gene /
protein, which is highly expressed in
liver tissue, can be converted into a BA
diagnostic marker which is helpful to prediction of prognosis in children and selection of surgical
surgical methods as an auxiliary means. Incurrent clinical practice, anti-inflammatory and anti-
fibrosis treatment cannot achieve ideal effect, and Kasai operation can not completely stop the progression of BA; however, a new
adjuvant therapy strategy is provided by Notch3 signaling pathway inhibitors, thereby beneficially improving hypoxia and
bile duct injury in portal area, slowing down
disease progression and raising survival rates of patients with BA liver