Method for establishing biliary atresia column diagram prediction model and application thereof

Abstract

The invention belongs to the field of biomedicine and molecular biology, and relates to a method for establishing a disease-related factor scoring parameter analysis model, in particular to a method for establishing a biliary atresia column diagram prediction model and an application thereof. The method comprises the steps: employing an rms packet to establish a Nomogram diagnosis column diagram based on multiple logistic regression analysis, wherein the Nomogram diagnosis column diagram comprises the selection of independent variables and quantification of weight scores of all factors in theindependent variables, and the independent variables comprise sex, weight, DB, logarithm (ALP) and logarithm (GGT). The established Nomogram diagnosis column diagram based on multivariate logistic regression analysis is helpful for determining the risk degree of biliary atresia according to scores in clinical practice. Furthermore, the established Nomogram diagnosis column diagram based on multiple logistic regression analysis can be used for analyzing scoring parameters of serum markers of biliary atresia and cholestatic infant hepatitis syndrome, and is beneficial to identification of BA andother forms of neonatal cholestasis (NC) with different causes of diseases.

Description

technical field [0001] The present invention relates to the field of biotechnology, and relates to a method for scoring parameter analysis models of disease-related factors, in particular to a method for establishing a nomogram prediction model of biliary atresia and its application. The model constructed by the present invention can be used to analyze biliary atresia and cholestasis Scoring parameters for serum markers of infantile hepatitis syndrome. Background technique [0002] It has been reported that biliary atresia (BA) is a rare but serious neonatal disease, which can rapidly develop into biliary cirrhosis and liver failure if not diagnosed and treated, and even die within 2-3 years after birth. According to statistics, in East Asia, the total neonatal incidence rate of BA is about 8000 per 10,000, which is significantly higher than that in the United States. As one of the largest pediatric hospitals in my country, the Children's Hospital Affiliated to Fudan Univers...

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Problems solved by technology

El-Guindi and colleagues reported that at the critical value (>286 units / liter), the serum activity of GGT had a diagnostic sensitivity of 76.7% and a specificity of 80% for BA; another study found that the GGT activity in serum was The Chinese population also showed a good ability to distinguish BA from other etiologies. However, practice has proved that the reliability, accuracy and reproducibility of γ-glutamyl transpeptidase (GGT) activity alone are questionable, e.g. , healthy newborns at birth have higher GGT levels, and the normal range of GGT levels can vary with age; in fact, GGT corrected for changes in age improves in the accuracy of predicting BA, to So far, the construction of a predictive model combining GGT with other BA-related factors has not been reported

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