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Composition comprising butyric acid compound and application of composition

A compound and composition technology, applied in the directions of drug combination, application, anhydride/acid/halide active ingredients, etc., can solve the problem of no safe and effective prevention and control measures, and achieve the promotion of cholestatic liver fibrosis, prevention and treatment of liver fibrosis. The effect of curing and preventing biliary atresia

Inactive Publication Date: 2018-07-17
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hepatic fibrosis complicated by biliary atresia is a kind of cholestatic liver fibrosis, and there are no safe and effective prevention and treatment measures at present

Method used

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  • Composition comprising butyric acid compound and application of composition
  • Composition comprising butyric acid compound and application of composition

Examples

Experimental program
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Effect test

Embodiment 1

[0042] This embodiment provides an infant formula milk powder containing coated butyric acid and a preparation method thereof. The method is as follows: adding food-grade coated butyric acid to infant formula milk powder, mixing evenly, and obtaining the product. The concentration of coated butyric acid in the prepared formula milk powder is 5mmol / L.

Embodiment 2

[0044] This embodiment provides a maternal formula milk powder containing sodium butyrate and a preparation method thereof. The method is as follows: adding food-grade sodium butyrate into the maternal formula milk powder and mixing evenly to obtain the product. The concentration of sodium butyrate in the prepared formula milk powder is 15mmol / L.

Embodiment 3

[0046] This embodiment provides a formula milk powder for premature infants containing butyrin and a preparation method thereof. The method is as follows: adding food-grade glyceryl butyrate into formula milk powder for premature infants, and mixing evenly to obtain the product. The concentration of butyrin in the prepared formula milk powder is 20mmol / L.

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Abstract

The invention provides a composition comprising a butyric acid compound and an application of the composition. The butyric acid compound is used for preventing and curing biliary atresia and the complications. The composition comprising the butyric acid compound comprises the butyric acid compound and a nutrition agent or a pharmaceutical aid, and the concentration of the butyric acid compound is5-70 mM. The intervention technique generally acting on the intestine is creatively used to prevent and cure the biliary atresia and the complications. As a safe effective preventing and curing method, the butyric acid compound is directly used or added in the nutrition agent and used for pregnant and newborn individuals having no symptoms, so that the occurrence and development of the biliary atresia is prevented and cured fundamentally. The composition solves the technical problems of prevention and cure of complications of the biliary atresia and hepatic fibrosis at the same time, and a safe economical effective method is provided for the prevention and cure of biliary atresia and hepatic fibrosis.

Description

technical field [0001] The invention relates to the technical field of food and medicine, in particular to a composition containing butyric acid compounds and its application in preventing and treating biliary atresia and its complications. Background technique [0002] Biliary atresia (BA) is a congenital malformation characterized by progressive obstruction of intrahepatic and extrahepatic bile ducts, with an incidence rate of 1 / 5000-1 / 8000. Most infants with BA usually do not have obvious symptoms within a few days after birth. With the progressive obstruction of extrahepatic and extrahepatic bile ducts, they gradually show obvious jaundice and clay-colored stools. Portojejunostomy is the treatment of choice for biliary atresia. However, even if bile duct patency is successfully restored by portojejunostomy, progressive bile duct obstruction will still occur after normal bile drainage, leading to rapid progression of liver fibrosis to cirrhosis. Without liver transplant...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61K31/22A61P1/16A61P1/00A23C9/16A23C9/152A23L33/10
CPCA23C9/152A23C9/16A23L33/10A23L33/40A23V2002/00A61K31/19A61K31/22A23V2200/30A23V2250/02
Inventor 文洁蔡威
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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