31 results about "Pathology specimens" patented technology

A computer-implemented method for tracking and processing a pathology specimen after collection comprises the step of creating a pathology specimen record with a unique specimen identification code for at least one specimen. The method further includes the step of creating a label for application to a container holding the specimen, wherein the label includes the unique specimen identification code and creating an order with a unique accession number after the container is forwarded for processing, by scanning the label.

A method for automatic evaluation, processing and / or testing of an anatomic pathology specimen is disclosed. The specimen is placed into a primary or secondary container labeled with a unique identification code, placed into a specimen carrier, and the carrier marked with an identification code which uniquely identifies the specimen and, by virtue of the identification code, the evaluation, processing and / or tests to be conducted thereon. The identification code may be in the form of a bar code, an RFID tag or similar device or any other identification that is either human read able, machine readable or electronically transferred. The specimen contained within the specimen container or within the specimen carrier is entered into the anatomic pathology, histology or molecular diagnostics LAS at a receiving station, which reads the identification code.

Systems and methods are provided for staining tissue with multiple biologically specific heavy metal stains and then performing X-ray imaging, either in projection or tomography modes, using either a plurality of illumination energies or an energy sensitive detection scheme. The resulting energy-weighted measurements can then be used to decompose the resulting images into quantitative images of the distribution of stains. The decomposed images may be false-colored and recombined to make virtual X-ray histology images. The techniques thereby allow for effective differentiation between two or more X-ray dyes, which had previously been unattainable in 3D imaging, particularly 3D imaging of features at the micron resolution scale. While techniques are described in certain example implementations, such as with microtomography, the techniques are scalable to larger fields of view, allowing for use in 3D color, X-ray virtual histology of pathology specimens.

The invention relates to the biotechnology area, and the spinal metastatic cancer prognosis judgment is the key to correct determine clinical development strategy, and in the invention, for the present spinal metastatic cancer related molecular biology prognosis judgment evaluation lacking problem, it constructs the spinal metastatic cancer prognosis related molecular marker tissue chip. By screening the clinical data and determining the random data spinal metastatic cancer pathological wax block to produce the spinal metastatic cancer tissue chip; selecting a variety of molecular markers and tissue chips for immunohistochemistry or in-situ hybridization, and through image analysis and quantitative measurement to analyze the expression instance of each molecular marker in the spinal metastatic cancer pathological specimens, and to analyze the relationship between the molecular markers expression and the patients prognosis, and screening the molecular markers which are closely related to the spinal metastatic cancer prognosis. The tissue chip provides a high-throughput, large sample, rapid detection tool for screening the spinal metastatic cancer prognostic related molecular markers, and provides a theoretical basis for the rational determination of the spinal metastatic cancer development strategies.

A system for reviewing digitized images of pathology specimens includes an image processing system and an image display system adapted to communicate with the image processing system. The image processing system is configured to receive a whole-slide digital image of a pathology specimen, segment the whole-slide digital image into a tissue-particle image within the whole-slide digital image, and represent the tissue-particle image as a plurality of image tiles such that each of the plurality of image tiles can be displayed sequentially on the image display system to permit a substantially complete, tile-by-tile review of the tissue-particle image in a predefined order.

The present invention provides a method, referred to as CpG retrieval, to overcome incomplete bisulfite modification of DNA recovered from formalin-fixed tissue samples. The method involves boiling deparaffinized tissue samples in citrate buffer, followed by DNA extraction for promoter methylation analysis. In general, the extracted DNA is further modified by sodium bisulfite and then subjected to a method of promoter methylation analysis. The present invention also reports that hypermethylation of ataxia-telangiectasia-mutated gene promoter is correlated with decreased overall survival in patient with head and neck squamous cell carcinoma.

The present invention provides a method, referred to as CpG retrieval, to overcome incomplete bisulfite modification of DNA recovered from formalin-fixed tissue samples. The method involves boiling deparaffinized tissue samples in citrate buffer, followed by DNA extraction for promoter methylation analysis. In general, the extracted DNA is further modified by sodium bisulfite and then subjected to a method of promoter methylation analysis. The present invention also reports that hypermethylation of ataxia-telangiectasia-mutated gene promoter is correlated with decreased overall survival in patient with head and neck squamous cell carcinoma.

It is possible to readily observe pathology specimens without spending much time and suspected pathology specimens in detail. A specimen observation device comprises an image capturing unit acquiring a partial image representing at least a part of one of multiple pathology specimens mounted on an accommodating section and a whole image of the multiple pathology specimens mounted on the accommodating section; an input unit inputting identification information of the accommodating section; a display unit displaying an enlarged version of the partial image acquired by the image capturing unit); an image designating unit designating the partial image displayed on the display unit; and a storage unit storing the identification information input via the input unit and a position of the partial image designated via the image designating unit in relation to the whole image such that the position and the identification information are associated with the whole image.

The invention relates to a countertop ultrasound imaging device and a method of using the same for pathology specimen evaluation. A tissue specimen imaging device, comprising: a container having an upwardly facing surface, adapted to receive a tissue specimen and a liquid, an ultrasound imaging assembly, adapted to automatically form a three dimensional image of the tissue specimen interior. In one preferred embodiment the device includes a transducer head that is automatically moved relative to the specimen.

A pathological sample delivery bottle for pathological departments, including a bottle body and a bottle cap, one end of the bottle body has an opening, the other end of the bottle body is a closed end, a specimen storage bottle is arranged inside the bottle body, and an annular step is arranged at the upper end of the bottle body , the upper end of the specimen storage bottle is provided with a convex edge, and the convex edge is set on the steps, the bottom of the specimen storage bottle is provided with a filter screen, and the liquid storage chamber is formed between the filter screen and the bottom of the bottle body, and a paraffin sealing layer is provided at the opening of the bottle body. The paraffin sealing layer is arranged above the specimen storage chamber, an external thread is provided at the opening of the outer wall of the bottle, and an internal thread matching the external thread is provided on the inner side of the annular side wall of the bottle cap. A pathological sample delivery bottle for pathological departments of the present invention has simple structure, convenient operation, tight seal, and convenient transportation. When sending for inspection, tissue samples and ascites samples can be separated and contained in the same bottle, and has the function of sterilization. Avoid cross infection.

A method for automatic evaluation, processing and / or testing of an anatomic pathology specimen is disclosed. The specimen is placed into a primary or secondary container labeled with a unique identification code, placed into a specimen carrier, and the carrier marked with an identification code which uniquely identifies the specimen and, by virtue of the identification code, the evaluation, processing and / or tests to be conducted thereon. The identification code may be in the form of a bar code, an RFID tag or similar device or any other identification that is either human read able, machine readable or electronically transferred. The specimen contained within the specimen container or within the specimen carrier is entered into the anatomic pathology, histology or molecular diagnostics LAS at a receiving station, which reads the identification code.

The invention relates to a medical appliance, in particular to a pathology specimen soaking device and a using method thereof. A specimen soaking plate can be moved up and down in a soaking bucket, can be fixed at a position with a certain height in the soaking bucket, and is provided with multiple specimen needle mounting holes. The bottom of the specimen soaking plate is provided with specimen soaking plate array slots. A specimen is completely soaked in a specimen soaking liquid when the specimen is soaked. According to the pathology specimen soaking device and the using method thereof, thesoaking effect is improved, the pathological diagnosis, the immunocytochemistry, and the molecular detection structure are more accurate, the specimen is prevented from deterioration caused by incomplete soaking, inversion of the specimen soaking plate during use is avoided, the specimen is fixed firmly and will not fall off, and a push-pull rod is connected to the specimen soaking plate to facilitate the picking and placing of the specimen. The material of the specimen soaking plate is PTFE which is not easy to stick to grease and is easy to clean after using. A bucket cover is provided to prevent the scent of the soaking liquid from spreading during the soaking process, so that environmental pollution will be prevented and the health of the medical staff will not be affected. The usingmethod is also simpler and more standardized.

The invention relates to a pathological tumor specimen fixator. The pathological tumor specimen fixator effectively solves the problems of fixation and safe transportation of a pathological tumor specimen; a technical scheme for solving the problems is as follows: the pathological tumor specimen fixator comprises a shell, wherein a plurality of transverse partition boards are arranged inside the shell; a bottom plate is connected with two movable shafts in a sliding manner; the two movable shafts are rotationally connected with two swing rods respectively; one ends of the two swing rods are rotationally connected to a circular center of an upper bottom; a center gear is coaxially and rotationally connected to the upper bottom; swing rod gears meshed with the center gear are rotationally connected to the two swing rods; the two swing rod gears are meshed with a swing rod gear ring fixedly connected to the upper bottom; the two swing rod gears are rotationally connected to the two opposite ends of a cross rotationally connected to the center gear; the cross can slide up and down; fixed gears are fixedly connected to the other two ends of the cross; the two fixed gears are meshed withtwo curved gear frames fixed connected to the upper bottom. The pathological tumor specimen fixator is succinct in structure, easy to use, good in safety performance and strong in practicality.

Systems and methods are provided for staining tissue with multiple biologically specific heavy metal stains and then performing X-ray imaging, either in projection or tomography modes, using either a plurality of illumination energies or an energy sensitive detection scheme. The resulting energy-weighted measurements can then be used to decompose the resulting images into quantitative images of the distribution of stains. The decomposed images may be false-colored and recombined to make virtual X-ray histology images. The techniques thereby allow for effective differentiation between two or more X-ray dyes, which had previously been unattainable in 3D imaging, particularly 3D imaging of features at the micron resolution scale. While techniques are described in certain example implementations, such as with microtomography, the techniques are scalable to larger fields of view, allowing for use in 3D color, X-ray virtual histology of pathology specimens.

It is possible to readily observe pathology specimens without spending much time and suspected pathology specimens in detail. A specimen observation device comprises an image capturing unit acquiring a partial image representing at least a part of one of multiple pathology specimens mounted on an accommodating section and a whole image of the multiple pathology specimens mounted on the accommodating section; an input unit inputting identification information of the accommodating section; a display unitdisplaying an enlarged version of the partial image acquired by the image capturing unit); an image designating unit designating the partial image displayed on the display unit; and a storage unit storing the identification information input via the input unit and a position of the partial image designated via the image designating unit in relation to the whole image such that the position and the identification information are associated with the whole image.

The invention relates to the technical field of pathological specimen measurement, and discloses a specimen measuring device and measuring method for tumor pathology. The specimen measuring device comprises a camera obscura assembly, the camera obscura assembly comprises a box body, an opening and closing plate, a placing plate, a glass cover piece, photosensitive specialty paper, a specimen placing groove and a first shading plate, the opening and closing plate is hinged to the outer surface of the box body, and the placing plate is arranged in the box body; when the specimen is measured, firstly, the photosensitive specialty paper is fixed in the box body, then the specimen is placed in the specimen placing groove, meanwhile, the lamp source is started to emit light to irradiate the photosensitive specialty paper in the box body, the specimen partially blocks the light, so that the lower photosensitive specialty paper forms a patch consistent with the specimen in shape, the shape of the plaque is consistent with the shape of the specimen, and the size of the specimen can be obtained by indirectly measuring the size of the plaque, so that a user can perform measurement without directly contacting the specimen, and the convenience and the safety of measurement are greatly improved.

The invention belongs to the technical field of medical articles, and particularly relates to a portable multipurpose pathology specimen box. The portable multipurpose pathology specimen box comprisesa box body, two or more rectangular grooves are formed in the side wall of the box body at equal intervals from top to bottom, the rectangular grooves are used for storing specimens, guide rails arearranged on the two sides of each rectangular groove, the guide rails are used for limiting the specimens, an observation groove is formed in the top end of the box body and communicated with the rectangular groove in the topmost end, a glass sheet is fixed to the bottom end of the observation groove, guide grooves are formed in the two sides of the observation groove, a magnifying lens is movablyinstalled between the guide grooves and used for observing the specimens, a box cover is movably installed on the side wall of the box body through a hasp, and a handle is rotationally installed on the side, away from the box body, of the box cover. According to the specimen box, the specimens can be preliminarily magnified by arranging the magnifying lens, so that observers can observe the specimens in places without magnifying equipment, the use convenience of the specimen box is improved, and meanwhile, the use functions of the specimen box are increased.

The invention provides a layered and cavity-divided pathology box based on tumor pathology test research, the layered and cavity-divided pathology box comprises a storage box and two groups of moving frames, the two groups of moving frames are correspondingly arranged on the two sides of the storage box, the two groups of moving frames are both provided with a plurality of groups of fixing assemblies, the fixing assemblies comprise mounting parts, the moving frames are provided with a plurality of groups of placing grooves, and the mounting parts are arranged in the placing grooves. The mounting pieces are arranged in the two corresponding sets of placing grooves, clamping grooves are formed in the mounting pieces, two sets of clamping plates are correspondingly arranged in the clamping grooves, multiple sets of limiting rods are arranged on the two sets of clamping plates, the clamping plates are arranged on the mounting pieces in a penetrating mode through the multiple sets of limiting rods, the multiple sets of limiting rods are sleeved with pressure springs, and the pressure springs are located in the clamping grooves; an opening and closing assembly is arranged in the storage box and connected with the two movable frames. Under the arrangement of the fixing assembly, the pathological specimen bags are placed in a layered and cavity-divided mode, and classification can be carried out so that medical staff can find the pathological specimen bags conveniently.

The invention discloses a surgical remnant cavity resection margin sampling pathological specimen box which comprises a cylindrical box body and a box cover. An inner cylinder is arranged in the middle of the box body, the inner cylinder is divided into four separated but adjacent parts at equal intervals, the parts are marked as B1, B2, B3 and B4, the space formed by the outer side of the inner cylinder and the box body is divided into 12 parts at equal intervals, the 12 parts are marked in sequence from 1h to 12 h. By means of the surgical remnant cavity resection margin sampling pathological specimen box, margin specimens can be divided in order, mixing can be effectively prevented, accuracy is improved, and workloads of people are reduced.

The invention discloses an online pathological specimen data management platform and a management method thereof. The online pathological specimen data management platform comprises a main server, a plurality of mobile terminals and a specimen storage module, wherein the mobile terminals are wirelessly connected with the main server; the main server comprises a data modeling module, a data generation module, a data encryption module and a data storage module; and each mobile terminal comprises a data input module. By the main server and the mobile terminals, unified management of pathological specimens is facilitated. The specimens are stored through the specimen storage module. The data processing module is used for creating a data model in a set asset library. The data input module is used for a worker to input related pathological specimen data. The data generation module generates different two-dimensional codes according to different pathological specimen data. The data encryption module encrypts the obtained pathological specimen data and decrypts the obtained pathological specimen data through a two-dimensional code generated by the data generation module. The specimen protection performance is high.

The invention discloses a pathological specimen sample delivery bottle for pathological department, which comprises a bottle body and a bottle cap, the bottle body comprises a first bottle body and asecond bottle body, the first bottle body and the second bottle body are fixedly connected, a glass slide clamping groove is formed in the bottle wall of the second bottle body, the first bottle bodyand the second bottle body are provided with a disinfectant bottle correspondingly, a barcode attaching part is arranged on the outside of the second bottle body, and an electronic tag is arranged onthe first bottle body. According to the pathological specimen sample delivery bottle for the pathological department, the structural design is reasonable, timely and effectively fixing of a pathological specimen can be achieved, sealing and light-shielding properties are good, volatilization and deterioration of the specimen are effectively avoided, double-bottle sampling can be used, the accuracyof the test result of the pathological specimen is ensured, the basic patient information of the pathological specimen is identified through a barcode and the electronic tag, inconvenience caused byan unclear handwritten tag is avoided, inspection time is ensured, operation is easy, time and labor are saved, and the pathological specimen sample delivery bottle for the pathological department issuitable for application and popularization.

In a method of operation of an artificial intelligence-equipped specimen scanning and analysis unit to digitally scan and analyze pathological specimen slides, a sample slide with a mounted tissue sample is scanned and analyzed according to one or more user-selected algorithms in order to generate a heatmap visually depicting the presence of one or more user-selected sample attributes of the tissue sample. One or more artificial intelligence modules, including a deep learning computation module, is provided and can be trained by the user for future analysis of new samples. One or more regions of interest may be selected from the heatmap to include in the results of the analysis. A focus window may be used to closely inspect any given region of the whole slide image, and a trail map is generated from the movement of the focus window.

A system for reviewing digitized images of pathology specimens includes an image processing system and an image display system adapted to communicate with the image processing system. The image processing system is configured to receive a whole-slide digital image of a pathology specimen, segment the whole-slide digital image into a tissue-particle image within the whole-slide digital image, and represent the tissue-particle image as a plurality of image tiles such that each of the plurality of image tiles can be displayed sequentially on the image display system to permit a substantially complete, tile-by-tile review of the tissue-particle image in a predefined order.

A computer-implemented method for labeling and tracking a pathology specimen after collection and positive patient identification comprises the step of creating a pathology specimen record with a unique specimen identification code for at least one specimen. The method further includes the step of creating a label for application to a container holding the specimen, wherein the label includes the unique specimen identification code and creating an order with a unique accession number after the container is forwarded for processing, by scanning the label. The unique identification code is utilized for tracking purposes to ensure that pathology specimens for the positively identified patient are not lost in transit to the pathology laboratory for further processing. This improves quality to the patient by the elimination of transcription errors, identification of missing or lost specimens, and confirmation that pathology specimens are correctly matched to a patient.

The invention provides a pathological specimen information processing method, system and device and a medium, and the method comprises the following steps: obtaining doctor's advice information of a patient, and generating initial specimen information of a pathological specimen; updating the initial specimen information according to the nodes of the pathological specimen in the conveying process to obtain specimen label information; generating registration information of the pathological specimen according to the doctor's advice information; verifying the registration information, and generating a pathological number of the specimen information and hospital discharge pre-information of the patient after verification is confirmed to be passed; associating the plurality of pathological specimens to the patient according to the pathological number, and generating a pathological report of the patient; according to the scheme, electronic management of the endoscopic pathological specimens can be achieved, the endoscopic pathological specimen management business process is reconstructed, the key problems of specimen label simplification, expense missing, terminal confirmation, paper record sheet electronization, process traceability and the like in the information transmission process are solved, and the method can be widely applied to the technical field of informatization management.

The invention relates to an accurate management method and system for access control authority of a specimen room in an operating room. The accurate management method for the access control authority of the operating room specimen room comprises the following steps: S1, configuring access control authorization information, wherein the access control authorization information is matched with operation arrangement information; S2, obtaining to-be-verified information of a person who is about to enter the specimen room; S3, judging whether the to-be-verified information is matched with the access control authorization information or not, if so, judging that the personnel has access authority, and entering step S4 and if not, returning to the step S2; and S4, controlling the access control to be relieved, and allowing the personnel to enter the specimen room. According to the method, the access control authorization information is configured according to the operation arrangement information, so that personnel related to the operation arrangement information have the authority to enter the specimen room, the storage safety of the pathological specimens is guaranteed, the management efficiency of the pathological specimens is effectively improved, and the medical risk is reduced.

A biological substance detection method for detecting a biological substance specifically in a pathological specimen, includes a step of immunologically staining the pathological specimen using a fluorescent label, a step of staining the pathological specimen with a staining reagent for morphology observation purposes (eosin) to observe the morphology of the pathological specimen, a step of irradiating the stained pathological specimen with excited light to cause the emission of a fluorescent and detecting the biological substance in the pathological specimen. In the step of immunologically staining the pathological specimen, a special fluorescent particle for which the excitation wavelength appears in a region that is different from the excitation wavelength region of eosin is used as the fluorescent label.

The invention discloses a detection device for pathological specimens sent for inspection, and relates to the technical field of pathological specimen processing. The invention includes a flushing device, a curing weighing device and a monitoring device. The lower surface of the flushing device is connected with the curing weighing device, and the monitoring device is only installed on one side of the curing weighing device. In the present invention, the pathological specimens are pretreated by setting a flushing device, and then the pretreated pathological specimens are transferred to a solidification weighing device and injected with a fixative, and a monitoring device is installed to monitor in real time whether the operation is standardized when injecting the fixative into the pathological specimens. And record it to facilitate subsequent operation traceability; through the cooperation of the flushing device and the curing weighing device, the process of injecting the curing liquid is isolated to reduce operational risks.