210 results about "Immune correlates" patented technology

The invention relates to compounds of formula (I):or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.

The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.

The invention relates to fully human antibodies, and fragments thereof, that bind to human interferon gamma (hIFNγ), thereby modulating the interaction between IFNγ and its receptor, IFNγ-R, and / or modulating the biological activities of IFNγ. The invention also relates to the use of such anti-IFNγ antibodies in the prevention or treatment of immune-related disorders and in the amelioration of a symptom associated with an immune-related disorder.

The present invention provides a method for the treatment of immune mediated or immune related diseases or disorders, infectious diseases, metabolic disorders and cancer in mammalian subjects. This method comprises the administration of a naturally occurring, mammalian intermediary metabolite or T cell receptor ligand, preferably a glucosylceramide, to a mammalian subject. In a preferred embodiment, such mammalian subjects are human beings.

The invention provides a small molecule compound. The small molecule compound is characterized in that the small molecule compound is a compound shown in a structural formula in the specification, ora stereoisomer, a geometric isomer, a tautomer, a racemate, a hydrate, a solvate, a metabolite, and a pharmaceutically acceptable salt or pro-drug thereof, wherein X1 and X2 are selected from carbon or nitrogen; Z is carbon or nitrogen; n1 is 0 and 1; n2 and n3 are the same or different, and are 0 or any natural numbers; a cyclic group represented by G is a saturated heterocyclic ring; any one orseveral hydrogen atoms on the saturated heterocyclic ring are substituted by R; and R is selected from hydrogen, halogen, alkyl, substituted alkyl, amino, amine group, substituted amine group, carboxyl, amido, substituted amido, ester group, substituted carbonyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, substituted sulfonyl, and substituted sulfoxide group. The small molecule compound of the invention can be used to treat, prevent and alleviate autoimmune diseases and / or immune-related inflammatory skin diseases.

The invention discloses a tumor immune subtype classification method and a tumor immune subtype classification system. The method comprises the following steps: acquiring a sample data set comprisingRNA-seq sequencing data and gene expression profile data of a plurality of tumor tissues; calculating microorganism abundance data, immune cell proportion data and gene expression data related to immunity in the tumor tissue corresponding to each sample in the sample data set; constructing a training sample data set by taking microorganism abundance data, immune cell proportion data and gene expression data related to immunity as classification features, expanding minority classes by adopting an SMOTE algorithm, training a random forest model, and improving the random forest model in a weighting form: increasing the weight of the minority classes. And thus, the decision tree classifier focuses on the minority class, and the classification accuracy of the minority class is improved. According to the invention, the accuracy of tumor immune subtype classification prediction can be improved, and a new target is provided for tumor immunotherapy.

The invention relates to the technical field of an application of bacteroides fragilis (BF) 839, in particular to an application of the bacteroides fragilis 839 to preparation of a medicine or food for treating or adjunctively treating immune-related diseases. The key effect of the bacteroides fragilis 839 in human intestinal tracts in treatment or adjuvant treatment of the immune-related diseasesis discovered for the first time, and the bacteroides fragilis 839 can be made into forms of pharmaceutical compositions, foods, health-care products or food additives by utilizing the key effect ofthe bacteroides fragilis 839 in the immune-related diseases. A pharmaceutical composition, a food, a health-care product or a food additive contains the bacteroides fragilis 839, can be used for treating the immune-related diseases, and has very important application value.

The present invention relates to novel process for the preparation of glycoproteins by mammalian cell culture wherein the sialic acid content of the glycoprotein produced is controlled over a broad range of values by manipulating the cell culture environment. The invention provides for processes in which the sialic acid content of the glycoprotein is modified by changes in cell culture parameters which affect cell specific productivity. Preferred embodiments of the invention include cell culture processes in the osmolality of the cell culture is controlled as well as the concentration of a transcription enhancer during the production phase of the cell culture. The invention further provides for novel preparations of soluble type 1 tumor necrosis factor immunoglobulin G1 and their uses in the treatment of inflammatory or immune related disorders.

The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.

The invention discloses a kit used for diagnosing the immune associated diseases of human or animals, and the kit comprises antibodies or cell factors, antibody antigens or the stimulation sources of the cell factors, and other reagents required by forming the kit, wherein the antibodies are two or more than two antibodies or sub-antibodies with the function of distinguishing different immune response types; and the cell factors are two or more than two cell factors with the function of distinguishing different immune response types. In the kit, a special biomarker serves as a diagnosis indicator to realize the purpose of diagnosis and the purpose of distinguishing different immune response types of the first class, the second class and the like. The diagnosis has the important meaning that the disease developing degree can be identified by the diagnosis indicator at the same time; and according to the dynamic variation of the indicator in a therapeutic process, clinicians can be correctly guided to regulate a therapeutic scheme in time, thereby properly treating diseases, and making a correct judgement for prognosis.