Immunity-related biomarker and application of biomarker to prognosis diagnosis of head and neck squamous cell carcinoma
A squamous cell carcinoma and biomarker technology, applied in immune-related biomarkers and its application in the prognostic diagnosis of head and neck squamous cell carcinoma, can solve the problem of immune phenotype prediction. Lack of biomarkers and other problems to achieve the effect of simple and easy detection methods
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[0030] From October 2014 to January 2015, we collected fresh tumor tissues and paired adjacent normal tissues from 5 pairs of postoperative HNSCC patients in the Department of Head and Neck Surgery, Cancer Hospital Affiliated to Nanjing Medical University for RNA sequencing analysis to obtain mRNA expression data. For specific clinical and pathological information, see Table 1. The genome-wide mRNA expression (normalized RPKM) RNA-seq data of HNSCC patients were downloaded from The Cancer Genome Atlas (TCGA) database (https: / / tcga-data.nci.nih.gov / tcga / ), and the patients’ gender, Clinicopathological data such as age, histological type, T, N, M stages and follow-up results, among which 416 HNSCC cases with complete gene expression data and TCGA clinical information were further analyzed. From June 2007 to June 2014, 115 patients with HNSCC undergoing head and neck surgery at the Affiliated Cancer ...
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