61 results about "Simultaneous stimulation" patented technology

The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and stimulate cells that maximizes stimulation and / or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and / or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and / or receptor signaling enhancement. Also provided are methods for producing phenotypically tailored cells, including T-cells for the use in diagnostics, drug discovery, and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having specific phenotypic properties produced by these processes are further provided.

The present invention relates generally to methods for stimulating cells, and more particularly, to a novel method to concentrate and / or stimulate cells that maximizes stimulation and / or proliferation of such cells. In the various embodiments, cells are stimulated and concentrated with a surface yielding enhanced proliferation, cell signal transduction, and / or cell surface moiety aggregation. In certain aspects methods for stimulating a population of cells such as T-cells, by simultaneous concentration and cell surface moiety ligation are provided by contacting the population of cells with a surface, that has attached thereto one or more agents that ligate a cell surface moiety and applying a force that predominantly drives cell concentration and cell surface moiety ligation, thereby inducing cell stimulation, cell surface moiety aggregation, and / or receptor signaling enhancement. Also provided are methods for producing phenotypically tailored cells, including T-cells for the use in diagnostics, drug discovery, and the treatment of a variety of indications, including cancer, viral infection, and immune related disorders. Compositions of cells having specific phenotypic properties produced by these processes are further provided.

Devices, systems and methods are provided for simultaneously stimulating the spinal anatomy at various locations, such as spinal levels, along the spinal cord. By stimulating multiple levels of the spinal column with the use of a single device, a single access path is created to an implantable pulse generator (IPG) rather than individual access paths for each lead at each spinal level to an IPG. By reducing the number of pathways, the procedure complexity, time and recovery are reduced. In addition, some embodiments provide additional specificity within each targeted level, such as selective stimulation of specific tissue, such as the dorsal root ganglion.

A method of providing therapy to a patient using at least one electrode is provided. The patient has a neural tissue region that is relatively close to the at least one electrode, and a neural tissue region that is relatively far from the at least one electrode. The method comprises conveying time-varying electrical energy from the electrode(s) into the relatively close and far neural tissue regions, wherein the electrical energy has a frequency and amplitude that blocks stimulation of the relatively close neural tissue region, while stimulating the relatively far neural tissue region.

A multichannel cochlear implant system spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.

A multichannel neurostimulation device spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.

A multichannel cochlear implant system spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.

The present invention provides a cochlear stimulation system and method for capturing and translating FTS in incoming sounds and delivering this information spatially to the cochlea. An embodiment of the system may comprise an FTS estimator / analyzer and a current navigator. An embodiment of the method of the invention can comprise: analyzing the incoming sounds within a time frequency band, extracting the slowly varying frequency components and estimating the FTS to obtain a more precise dominant FTS component within a frequency band. After adding the fine structure to the carrier to identify a precise dominant FTS component in each frequency band (or stimulation channel), a stimulation current is steered to the precise spatial location on the cochlea that corresponds to the dominant FTS component, the steering accomplished by delivering non-simultaneous stimuli through at least two electrodes.

Systems, devices and methods for applying therapeutic transcranial magnetic stimulation (TMS) to at least one superficial cortical target brain region and at least one deep brain target so that the induced current points between the superficial cortical and deep brain targets. Systems may include two TMS electromagnets configured for treating a patient by stimulating at least one deep brain region with one TMS magnet at the same time that a second TMS magnet stimulates at least one superficial cortical brain region. Also described are positioners to secure at least two TMS magnets in a substantially fixed arrangement relative to the patient's head, while allowing for fine adjustment of position and orientation of each of the TMS magnets individually to conform them to the shape of the contact surface of the body and to direct the vector direction of the overall induced current from the magnets.

Tubewaves are used for detection and monitoring of feature state to enhance stimulation operations and remediate failure conditions. For example, proper sealing of perforations may be confirmed based on lack of a reflection of a tubewave by the perforations. Alternatively, at least one of amplitude, frequency, attenuation, dispersion and travel time associated with a tubewave and reflection may be used to determine feature state. If a sealant fails during treatment then the failure condition is indicated by appearance of a tubewave reflection. Consequently, the stimulation operation can be stopped in a timely manner, and remediation by means, for example, of pumping diversion fluid or dropping of balls, can be reinitiated until the difference between the expected responses and responses measured by the instrument along the segment to be stimulated confirm that sealing has taken place and that stimulation of the intended zone can resume. Further, specific remediation steps may be selected based on response of the borehole system to tubewaves. The efficacy of the selected remediation steps may also be determined by response of the borehole system to tubewaves during or after execution of those steps.

A programmable cochlear implant system utilizes multiple-resolution current sources and flexible data-encoding scheme for transcutaneous transmission. In certain embodiments, the number of current sources may be equal to or greater than 2, but equal or less than N−1, where N is the number of electrodes. The multi-resolution current source may introduce offset currents to achieve perceptually-based multiple resolutions with high resolution at low amplitudes and low resolution at high amplitudes. The flexible data-encoding scheme may allow arbitrary waveforms in terms of phase polarity, phase duration, pseudo-analog-waveform, while producing high-rate and high-temporal-precision stimulation. In one embodiment, a 2-current-source system may support simultaneous and non-simultaneous stimulation as well as monopolar, bipolar, pseudo-tripolar, and tripolar electrode configurations.

Disclosed herein is an animal training device and method of controlling the same. The animal training device includes a transmitter and at least one receiver. The transmitter transmits RF signals according to manipulation of function switches, and has emergency stimulation mode in which an RF control signal is transmitted by adding a predetermined level to a low-frequency stimulation level set for each individual animal, simultaneous stimulation mode in which an RF control signal is transmitted by adding a predetermined level to low-frequency stimulation levels set for animals, and constant stimulation alternation mode in which an RF control signal is transmitted by automatically varying a period of a low-frequency stimulation. The receiver sets low-frequency stimulation for a corresponding one of the plurality of animals in response to the RF signals, and selectively performs operations corresponding to the emergency stimulation mode, the simultaneous stimulation mode, and the constant stimulation alternation mode.

A stimulation system including a stimulator having a multi-channel electrode array utilizing a monopolar electrode configuration. A processor is operatively coupled to the stimulator. The processor is configured to determine a channel interaction (CI) sequence using simultaneous, sign-correlated pulses and channel interaction compensation. The CI sequence has a CI pulse rate and a CI mean pulse amplitude, and produces resulting potentials that are substantially equal to desired potentials at given positions relative to the multi-channel array. The CI sequence may include temporal gaps between pulses, wherein the processor may be configured to increase the CI pulse rate, such that the temporal gap between pulses is decreased. Furthermore, the processor may be configured to reduce the pulse amplitude of the CI sequence while increasing pulse phase duration, such that charge per pulse remains substantially unchanged and the temporal gap between pulses is decreased.

Sound processing strategies for use with cochlear implant systems utilizing simultaneous stimulation of electrodes are provided. The strategies include computing a frequency spectrum of a signal representative of sound, arranging the spectrum into channels and assigning a subset of electrodes to each channel. Each subset is stimulated so as to stimulate a virtual electrode positioned at a location on the cochlea that corresponds to the frequency at which a spectral peak is located within an assigned channel. The strategies also derive a carrier for a channel having a frequency that may relate to the stimulation frequency so that temporal information is presented. In order to fit these strategies, a group of electrodes is selected and the portion of the current that would otherwise be applied to electrode(s) having a partner electrode in the group is applied to the partner electrode.

Sound processing strategies for use with cochlear implant systems utilizing simultaneous stimulation of electrodes are provided. The strategies include computing a frequency spectrum of a signal representative of sound, arranging the spectrum into channels and assigning a subset of electrodes to each channel. Each subset is stimulated so as to stimulate a virtual electrode positioned at a location on the cochlea that corresponds to the frequency at which a spectral peak is located within an assigned channel. The strategies also derive a carrier for a channel having a frequency that may relate to the stimulation frequency so that temporal information is presented. In order to fit these strategies, a group of electrodes is selected and the portion of the current that would otherwise be applied to electrode(s) having a partner electrode in the group is applied to the partner electrode.

Disclosed herein is an animal training device and method of controlling the same. The animal training device includes a transmitter and at least one receiver. The transmitter transmits RF signals according to manipulation of function switches, and has emergency stimulation mode in which an RF control signal is transmitted by adding a predetermined level to a low-frequency stimulation level set for each individual animal, simultaneous stimulation mode in which an RF control signal is transmitted by adding a predetermined level to low-frequency stimulation levels set for animals, and constant stimulation alternation mode in which an RF control signal is transmitted by automatically varying a period of a low-frequency stimulation. The receiver sets low-frequency stimulation for a corresponding one of the plurality of animals in response to the RF signals, and selectively performs operations corresponding to the emergency stimulation mode, the simultaneous stimulation mode, and the constant stimulation alternation mode.

An implantable stimulation device is disclosed which provides for reduced power consumption when compared with bipolar stimulation and better stimulation performance when compared with monopolar stimulation. Implantable stimulator devices use less power in monopolar stimulation mode than that of bipolar stimulation but stimulation performance is greater when using bipolar stimulation. The device comprises circuitry capable of simultaneous stimulation between a reference electrode and an electrode of a stimulation array and between electrodes of the stimulation array, the ratio of current to the reference electrode and array electrodes being selectable.

A lead for deep brain stimulation includes a first electrode group and a second electrode group. The first electrode group includes at least one first electrode which is adapted for being positioned in a nucleus accumben of a brain. The second electrode group includes at least one second electrode which is adapted for being positioned in an anterior limb of an internal capsule of the brain. With one single lead implanted in the brain, the first electrode group and the second electrode group simultaneously stimulating the nucleus accumben and the anterior limb of the internal capsule, and the present disclosure improves the effect and safety of DBS in the therapy of drug-addiction, OCD and / or depression.

The present invention relates to a modular erogenous stimulation system including at least one vibratory device for stimulating the erogenous zones and at least one control module that for controlling the operation of the vibratory device; and to an embodiment of the at least one vibratory apparatus that may be worn by a female for stimulating the internal vaginal erogenous zones, the external clitoral erogenous zones, or both the internal and external clitoral erogenous zones of the female genitalia simultaneously, while allowing sufficient clearance of the vaginal canal to also permit insertion of a penis or other similarly configured and dimensioned implement, such as a dildo or vibrator, when the apparatus is being properly worn by the female to create an interaction between the partners that is pleasurable for all involved.

Devices, systems and methods are provided for simultaneously stimulating the spinal anatomy at various locations, such as spinal levels, along the spinal cord. By stimulating multiple levels of the spinal column with the use of a single device, a single access path is created to an implantable pulse generator (IPG) rather than individual access paths for each lead at each spinal level to an IPG. By reducing the number of pathways, the procedure complexity, time and recovery are reduced. In addition, some embodiments provide additional specificity within each targeted level, such as selective stimulation of specific tissue, such as the dorsal root ganglion.

A process and laser system for in vitro and in vivo pain research, pain clinical testing and pain management. In preferred embodiments of the present invention a diode laser operating at a 980 nm wavelength is used to produce warmth, tickling, itching, touch, burning, hot pain or pin-prick pain. The device and methods can be used for stimulation of a single nerve fiber, groups of nerve fibers, nerve fibers of single type only as well as more the one type of nerve fibers simultaneously. The present invention is especially useful for research of human / animal sensitivity, pain management, drug investigation and testing, and psychophysiology / electrophysiology studies. The device and methods permit non-contact, reproducible and controlled tests that avoid risk of skin damage. Applicant an his fellow workers have shown that tests with human subjects with the process and laser of the present invention correlate perfectly with laboratory tests with nerve fibers of rats. The device and the methods can be applied in a wide variety of situations involving the study and treatment of pain. Preferred embodiments of the present invention provide laser systems and techniques that permit mapping and single mode activation of C fibers and A-delta fibers.

The invention discloses an earphone-type transcranial micro current stimulation device, which is used for treating depression and insomnia, releasing pressure and adjusting emotions. The device comprises earplug-type stimulation electrodes, a central control unit, a stimulation wave generation unit, a power management unit and a mobile phone control app. The transcranial micro current stimulation device is integrated with the earphones, and apart from the additional stimulation device, the appearance of the whole device is the same as that of commonly-used earplug-type earphones. The mobile phone app communicates with the central control unit via a Bluetooth for controlling the whole micro current stimulation process; the central control unit controls the strength, the frequency and the waveform of stimulation waves through controlling the stimulation wave generation unit; the stimulation electrodes and the earphone earplugs are integrated, and stimulation current carries out micro current stimulation on the brain via auricles; and the stimulation device has functions of the common earphones, the mobile phone app can download relaxing music according to requirements of the user, the stimulation device is inserted in a mobile phone earphone interface and then, micro current stimulation treatment and music treatment can be carried out at the same time.

A method of providing therapy to a patient using at least one electrode is provided. The patient has a neural tissue region that is relatively close to the at least one electrode, and a neural tissue region that is relatively far from the at least one electrode. The method comprises conveying time-varying electrical energy from the electrode(s) into the relatively close and far neural tissue regions, wherein the electrical energy has a frequency and amplitude that blocks stimulation of the relatively close neural tissue region, while stimulating the relatively far neural tissue region.

An anti-reentry apparatus and method for reverting ventricular arrhythmias. Biphasic stimulation is applied at multiple ventricular sites to revert arrhythmias caused by reentry, particularly multiple random reentry. In the preferred embodiment, the first phase of biphasic stimulation is anodal, and is at a maximum subthreshold amplitude. The anodal phase preconditions the myocardium to accept the second phase (cathodal) such that less electrical energy is required to reach the threshold amplitude to produce depolarization. The anodal phase stimulation may have a shape over time that is square wave, ramped, or a series of short square wave pulses. Multiple electrodes located at multiple ventricular sites may be stimulated simultaneously, or they may be sequentially stimulated over time in a manner mimicking the normal progress pattern of cardiac depolarization. The multiple ventricular electrodes may stimulate from internal or external surfaces. One or both ventricles may receive biphasic stimulation from multiple electrodes. The invention also may be practiced with respect to atria.

The invention discloses a controllable wireless cardiac pacemaker system with multi-electrode pacing, which belongs to the field of electrical stimulation medical devices. The wireless pacemaker system has four or more fixed hooks, the pacing electrode is positioned on the anchoring hooks of the implant device, as long as one of the fixation hooks is punctured in the myocardium, it can function asa pacing. The pacemaker system has an electrode 'compensation' function, and when a single electrode is lost, the other electrode is controlled to be used for pacing without performing a second operation. In addition, the pacemaker system employs a chip (e. g., 74 LS148 and the like.) that can control the number of uses of the electrodes remotely according to the actual clinical situation of thepatient, achieve simultaneous stimulation of the four electrodes, or three electrode stimulation, or both electrode stimulation, or any of the electrode stimulation, and the stimulation intensity is adjustable. The system of the invention increases the probability of the electrode targets to contact the myocardium, reduces the risk of perforation during implantation of the pacemaker, reduces the number of re-implantation of the myocardial necrosis patient, prolongs the service life of the implantation device, and the simulation intensity varies according to patients, and it has great referencevalue and application value to the active implantation device.

The invention discloses a four-coil structure for transcranial magnetic stimulation and an application thereof and belongs to the transcranial magnetic stimulation field. The four-coil structure comprises four adjacent small coils in a square structure, two energy storage capacitors and 12 relays, wherein positive and negative leading wires are independently led out by each small coil, a positive electrode leading-out wire of each energy storage capacitor is connected with a silicon controlled rectifier as a discharging switch, and the two energy storage capacitors are used for controlling different relays or relay combinations for supplying power for different small coils or small coil combinations. The four-coil structure is advantaged in that magnetic stimulation focuses of multiple portions of a human brain can be simultaneously stimulated, and complex magnetic stimulation demands are satisfied.

Neuromuscular stimulation is widely used for rehabilitation and movement assist devices, due to its safety, efficacy, and ease of operation. For repeatable and accurate muscular contractions, a voltage controlled current sources (VCCS) with high compliance is required. Conventional VCCS design requires high-voltage rated operational amplifiers, which are expensive and consume large power. Moreover, conventional stimulators are not viable for simultaneous stimulation of muscle synergies, as they require multiple VCCS operating at the same time. This invention presents a neuromuscular stimulator with a multistage driver circuit wherein, a VCCS connected to an output driving stage comprising of folded-cascode transistor buffers and a bidirectional current mirror circuit. The multistage driver circuit uses inexpensive low-voltage rated operational amplifiers that consume 95% less power. Additionally, we disclose a stimulation method wherein only a single current source drives several output drivers connected in series or parallel to simultaneously stimulate multiple muscles or muscle synergies.