Product
Patsnap Eureka
For R&D, Patsnap Eureka makes reading and utilizing patents & technical documents easy.
Patsnap Eureka AIR
Designed for self-driven R&D workflows. Generate viable solutions, solve complex R&D challenges, empower your innovation with AI.
Patsnap Eureka Materials
Designed for material experts only. Revolutionize your material R&D, from search, analyze, to developing new materials.
Feature
TechResearch
Generate reliable direction feasibility study reports for your R&D in just a few steps.
TechSeek
Discover and master advanced knowledge NOW. Basics, ideas, possibilities, all at once.
TechMind
As an expert in R&D Theories, TechMind can generates customized viable solutions instantly.
TechRisk
Analyze your overall solution with one click, know your potential R&D risks in advance.
TechMonitor
Get weekly tech updates, stay abreast of the latest tech innovations and key insights.
Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
47 results about "Heterogeneous population" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
A heterogenous population is one where individuals are not similar to one another. For example, you could have a heterogenous population in terms of humans that have migrated from different regions of the world and currently live together.
Isolating cells expressing secreted proteins
InactiveUS6919183B2Easy to detectImprove isolationCompound screeningApoptosis detectionSecretory proteinCell sheet
A method for identifying and isolating cells which produce secreted proteins. This method is based upon a specific characteristic or the expression level of the secreted protein by transiently capturing the secreted protein on the surface of an individual cell, allowing selection of rare cell clones from a heterogeneous population. Also provided is the use of this method to generate cells which produce a desired level of secreted protein or secreted protein of a particular characteristic(s), and organisms which possess such cells. In particular, the method allows rapid isolation of high expression recombinant antibody-producing cell lines, or may be applied directly to rapid isolation of specific hybridomas, or to the isolation of antibody-producing transgenic animals. This method is applicable for any cell which secretes protein.
Owner:REGENERON PHARM INC
Microfluidic device for cell and particle separation
A microfluidic separation device includes a microchannel formed in a substrate and being defined at least by a bottom surface, a first side wall, and second side wall. Fluid containing particles or cells is flowed through the microchannel from an upstream end to a downstream end. The downstream end terminates in a plurality of branch channels. A plurality of vertically-oriented electrodes are disposed on the first wall and on the second wall opposite to the first wall. A voltage source is connected to the plurality of opposing electrodes to drive the electrodes. The opposing, vertically-oriented electrodes may be used to focus a heterogeneous population of particles or cells for subsequent downstream separation via additional electrodes placed on one of the side walls. Alternatively, the opposing, vertically-oriented electrodes may be used to spatially separate a heterogeneous population of particles or cells for later collection in one or more of the branch channels.
Owner:RGT UNIV OF CALIFORNIA
Devices and processes for nucleic acid extraction
ActiveUS20090215125A1Bioreactor/fermenter combinationsBiological substance pretreatmentsFlat glassBinding site
Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites.
Owner:BLOOD CELL STORAGE
Transfection of human embryonic stem cells
InactiveUS20020127715A1Nervous disorderGenetic material ingredientsGene Expression AlterationGenetic Materials
Methods are provided for altering gene expression in a population of human embryonic cells that include introducing a gene expression altering sequence into cells the cells retaining their pluripotent character, for purifying pluripotent embryonic stem cells from a heterogeneous population of cells, and for treating a human suffering from a deficiency of a selected cell type. Reagent cell populations are further provided for supplying material for transplantation consisting essentially of pluripotent human embryonic stem cells modified by foreign genetic material.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
Analysis of sulfated polysaccharides
ActiveUS7575886B2Easy to measureImproved propertyOrganic active ingredientsSenses disorderSulfated polysaccharidesHeterogeneous population
The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
Owner:MOMENTA PHARMA
Devices and processes for nucleic acid extraction
ActiveUS8163535B2Bioreactor/fermenter combinationsHeating or cooling apparatusFlat glassBinding site
Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface effective for binding a heterogeneous population of nucleic acids. The first port, second port, and binding chamber define a continuous fluid pathway that is essentially free of nucleic acid-specific binding sites.
Owner:BLOOD CELL STORAGE
Vascularized cardiac tissue and methods of producing and using same
InactiveUS20090169521A1BiocideMammal material medical ingredientsHeterogeneous populationCell biology
An isolated composition of matter is disclosed. The composition comprises a heterogeneous population of cells seeded on a scaffold, wherein the heterogeneous population of cells comprises cardiomyocytes, endothelial cells and fibroblast cells. Pharmaceutical compositions comprising same and uses thereof are also disclosed.
Owner:TECHNION RES & DEV FOUND LTD
Method for double staining in immunohistochemistry
ActiveUS20100151447A1Measurably differentMicrobiological testing/measurementBiological testingTissue sampleCo localization
The present invention relates to kits and methods for performing dual-staining immunohistochemistry (IHC) for the detection of specific cell populations in tissue samples containing heterogeneous populations of cells, which can be observed by a light microscope for co-localization of distinct pigments. The method includes providing a tissue sample comprising fixed cells; exposing the sample to first and second ligands that recognize different marker proteins found at the same cellular location, thereby forming a ligand-labeled sample; exposing the ligand-labeled sample to first and second labeling reagents, the first labeling reagent binding to the first ligand and the second labeling reagent binding to the second ligand, the first and second labeling reagents each forming distinct pigments; and identifying the number of cells that display only one particular pigment, or more than one pigment, by the different coloration of the cellular location labeled by the distinct pigment.
Owner:CORNELL UNIVERSITY
Carriers for combinatorial compound libraries
InactiveUS20110312613A1Chemical library matterOrganic chemistry methodsCarrier signalCombinatorial chemistry
A carrier pre-encoded with information sufficient to distinguish it from a heterogeneous population of carriers is disclosed on which a compound can be synthesised. The carrier has two attributes integrally associated therewith, which attributes are detectable and / or quantifiable during synthesis of the compound and which define a code identifying the carrier before, during and after said synthesis, with the proviso that one of said attributes is other than shape, or surface deformation(s) of the carrier. The invention also encompasses a plurality of carriers that are pre-encoded as above and a method of synthesising and deconvoluting a combinatorial library using such carriers.
Owner:NANOMICS BIOSYST
Cementitious composition
A cementitious composition is provided which contains between 25% to 90% plastics particles (102) and has no conventional rock aggregate present. A heterogeneous population of plastics particles (102) may be present and the particles are preferably obtained from wastestream plastics materials. Articles (101) made form the cementitious composition are lightweight and may be utilised in building-related industries.
Owner:BARROW PETER HAMISH
Isolating cells expressing secreted proteins
InactiveUS20050186623A1DifferentiateImprove the level ofCompound screeningApoptosis detectionBiological bodyRare cell
A method for identifying and isolating cells which produce secreted proteins. This method is based upon a specific characteristic or the expression level of the secreted protein by transiently capturing the secreted protein on the surface of an individual cell, allowing selection of rare cell clones from a heterogeneous population. Also provided is the use of this method to generate cells which produce a desired level of secreted protein or secreted protein of a particular characteristic(s), and organisms which possess such cells. In particular, the method allows rapid isolation of high expression recombinant antibody-producing cell lines, or may be applied directly to rapid isolation of specific hybridomas, or to the isolation of antibody-producing transgenic animals. This method is applicable for any cell which secretes protein.
Owner:REGENERON PHARM INC
Methods of selecting stem cells and uses thereof
A method of selecting stem cells from heterogeneous population of cells is disclosed. The method comprises contacting the population of cells with an apoptosis inducing agent under conditions which are apoptotic to non-stem cells and non-apoptotic to stem cells, thereby selecting the stem cells from the heterogeneous population of cells. The selected stem cells may then be used for a variety of applications including transportation and differentiation.
Owner:CELLECT BIOTECH
Multi-stage, multiplexed target isolation and processing from heterogeneous populations
A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal.
Owner:THE BROAD INST INC +2
T cell compositions for immunotherapy
InactiveUS20200237819A1Minimal exhaustion markerHigh expressionMammal material medical ingredientsBlood/immune system cellsAntigenT cell
The invention relates to compositions comprising a heterogeneous population of T cells with reactivity to selected antigens that are useful for adoptive immunotherapy and methods for making the T cell compositions.
Owner:GENEIUS BIOTECH
T cell compositions for immunotherapy
PendingCN109715788AImprove expression levelHigh antigen reactivityMammal material medical ingredientsDepsipeptidesAntigenMedicine
The invention relates to compositions comprising a heterogeneous population of T cells with reactivity to selected antigens that are useful for adoptive immunotherapy and methods for making the T cellcompositions.
Owner:GENEIUS BIOTECH
Sorting Biological and Non-Biological Moieties Using Magnetic Levitation
ActiveUS20180280977A1Easy to moveInexpensive and robustImage enhancementImage analysisMulti unitPoint of care
Systems and methods for levitating populations of moieties, cells, or other such units using one or more magnets in a microfluidic environment are provided. These systems and methods may be used to, for example, separate or sort heterogeneous populations of the units from one another, to assembly a multi-unit assembly during the levitating of the units, and to evaluate samples at the point of care in real-time. These systems and methods may also utilize a frame that enables an imaging device, such as a smartphone, to capture the units in real time as they are manipulated in the system.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Novel multivalent nanoparticle-based vaccines
Novel, nanoparticle-based vaccines are provided that elicit an immune response to a broad range of infectious agents, such as influenza viruses. The nanoparticles comprise a heterogeneous population of fusion proteins, each comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to one or more immunogenic portions of a protein from an infectious agent, such as influenza virus. The fusion proteins self- assemble to form nanoparticles that display a heterogeneous population of immunogenic portions on their surface. When administered to an individual, such nanoparticles elicit an immune response to different strains, types, subtypes and species with in the same taxonomic family. Thus, such nanoparticles can be used to vaccinate an individual against infection by different Types, subtypes and / or strains of infectious agents. Also provided are specific fusion proteins, nucleic acid molecules encoding such fusion proteins and methods of using nanoparticles of the invention to vaccinate individuals.
Owner:US DEPT OF HEALTH & HUMAN SERVICES
High-throughput single cell sorting using microbubble well arrays
InactiveUS20170074872A1Simple conditionsBiomass after-treatmentTissue/virus culture apparatusBiologyHeterogeneous population
The present invention provides a microfabricated device and methods for high throughput single cell screening of a heterogeneous population. The present invention is partly based upon but not limited to sorting by monitoring cell secreted factors that accumulate in time (hours, days, weeks) as cells are cultured in the microbubble well niche the architecture of which facilitate the accumulation. In certain embodiments, the device and method comprises a means to identify effective drugs for personalize therapeutics such as but not limited to discovery of monoclonal antibody therapeutics.
Owner:NIDUS BIOSCI LLC
Statistical modeling method for measuring and calculating carbon emission scale
PendingCN114707120APracticalHigh precisionForecastingTechnology managementPrincipal component analysisComputational physics
The invention provides a statistical modeling method for measuring and calculating a carbon emission scale, which is characterized in that the conditions that data is from a heterogeneous population and the data has deflection are considered, and which factor and the influence degree of carbon emission are researched. Comprising the following steps: step 1, collecting carbon emission data of a plurality of regions; 2, analyzing factors influencing the carbon emission scale, and searching related data about novel urbanization; 3, constructing a novel urbanization evaluation system to define the urbanization level; 4, estimating the carbon emission of the region by using an emission factor method; step 5, analyzing carbon emission data of each area by using a Tapio unhooking model, and finding out individual differences and generality; 6, studying factors influencing the carbon emission scale by adopting an STIRPAT model, and reducing the multicollinearity by using a principal component analysis method; and 7, measuring and calculating the carbon emission data by using a hybrid expert regression model.
Owner:KUNMING UNIV OF SCI & TECH
Sterilization method for edible mushroom culture
InactiveCN102771315APromote growthImprove working environmentGaseous substancesChemicalsBiotechnologyDisease
The invention discloses a sterilization method for edible mushroom culture. The sterilization method comprises the steps of (1) sterilizing a mushroom house: closing doors and windows to seal a house being 15-30 square meters, and sterilizing for 0.8-1.5hours by ozone; (2) sterilizing a culture medium: preparing the culture medium according to the formula, paving and airing the culture medium on a shelf in the house, and sterilizing for 0.8-1.5hours by ozone; and (3) sterilizing in culture: moving inoculated strains into the mushroom house, sterilizing for 0.4-1.0hour by ozone, and observing the growth condition of the edible mushroom everyday. Compared with the prior art, the sterilization method for edible mushroom culture has the advantages that heterogeneous population caused by the reason that the compost is not sterilized thoroughly, the inoculating process is not standard, the strains carry disease germs, the site conditions are poor and the like can be thoroughly sterilized, and the edible mushroom is prevented from being infected.
Owner:四川宜爱菌业有限公司
Analysis of sulfated polysaccharides
InactiveUS20090061411A1Easy to measureImproved propertySenses disorderNervous disorderSulfated polysaccharidesHeterogeneous population
The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
Owner:MOMENTA PHARMA
Method for analyzing markers on the surface of vesicles
InactiveUS20160334402A1Less discriminateBiological particle analysisIndividual particle analysisHeterogeneous populationSignal intensity
The present invention provides a method for analyzing levels of markers of subpopulations of vesicles in a sample comprising a heterogeneous population of said vesicles, the method comprising a) contacting said sample with a set of at least two capture agents, marker of said vesicles; thereby capturing at least two subpopulations of said vesicles, b) contacting the captured at least two subpopulations of vesicles with at least two different detection agents, thereby labeling at least two markers of said at least two subpopulations of said vesicles inversely with said at least two capture agents and at least two detection agents, thereby generating an at least 2×2 matrix of signal intensities, and c) determining the levels of said at least two markers of said at least two subpopulations of said vesicles, wherein said levels of said at least two markers of subpopulations of said vesicles are determined relative to each other.
Owner:MILTENYI BIOTEC B V & CO KG
Novel adeno-associated virus (AAV) vectors, aav vectors having reduced capsid deamidation and uses therefor
A recombinant adeno-associated virus (rAAV) vector comprising an AAV capsid having a heterogeneous population of vp1 proteins, a heterogeneous population of vp2 protein and a heterogeneous populationof vp3 proteins. The capsid contains modified amino acids as compared to the encoded VP 1 amino acid sequence, the capsid containing highly deamidated asparagine residues at asparagine-glycine pair, and further comprising multiple other, less deamidated asparagine and optionally glutamine residues. Methods of reducing deamidation in the AAV capsid of a rAAV are provided.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA
System and method for cell levitation and monitoring
ActiveUS10928404B2Improve accuracyReduce throughputCompound screeningApoptosis detectionMonitoring systemCellular process
Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV +2
Vascularized islets and methods of producing same
Owner:TECHNION RES & DEV FOUND LTD
Generation of a population of hindbrain cells and hindbrain-like organoids from pluripotent stem cells
PendingUS20210284962A1Gene expression in the population of hindbrainCatalytic crackingNervous system cellsBiotechnologyPluripotential stem cell
Provided herein are methods of generating hindbrain cells, including respiratory hindbrain cells, from pluripotent stem cells. Also provided are methods of generating a three-dimensional organoid comprising a population of hindbrain cells including a heterogeneous population of interneurons.
Owner:THE J DAVID GLADSTONE INST A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J DAVID GLADS +1
Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
ActiveUS20150182604A1Prevent uncontrolled bleedingPeptide/protein ingredientsHydrolasesPost translationalProtein composition
Compositions are provided comprising recombinant variants of the human clotting Factor Xa. Such compositions include a wide variety of isoforms and post-translational modifications of FXa and are useful for treating subjects in need of hemostasis.
Owner:PFIZER INC
Compositions and methods for diagnosing tumors using LEDGF/p75
InactiveUS8168393B2Microbiological testing/measurementPeptide preparation methodsAbnormal tissue growthMammal
Owner:THE BRIGHAM & WOMEN S HOSPITAL INC
Multi-stage, multiplexed target isolation and processing from heterogeneous populations
A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal.
Owner:THE BROAD INST INC +2
Methods of selecting stem cells and uses thereof
A method of selecting stem cells from heterogeneous population of cells is disclosed. The method comprises contacting the population of cells with an apoptosis inducing agent under conditions which are apoptotic to non-stem cells and non-apoptotic to stem cells, thereby selecting the stem cells from the heterogeneous population of cells. The selected stem cells may then be used for a variety of applications including transportation and differentiation.
Owner:CELLECT BIOTECH
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com