65 results about "Glutamic Acid Derivatives" patented technology

Glutamic acid derivatives, in particular monatin, may be conveniently prepared by alkylating a 4-protected hydroxyl pyroglutamic acid derivative with an alkylating agent to prepare a 4-protected hydroxyl-4-alkylglutamic acid derivative, followed by the steps of hydrolysis and deprotection. The 4-protected hydroxyl pyroglutamic acid derivative is easy to produce from hydroxyproline. The 4-protected hydroxyl pyroglutamic acid derivative is particularly suitable for use in the efficient manufacture of monatin of high optical purity, since it can be alkylated selectively at the 4-position and stereoselectively and after its alkylation, it can easily be converted to a glutamic acid derivative.

The invention relates to novel diazoketone derivatives. The invention also relates to processes for homologation of these diazoketone derivatives. The processes are useful for preparing compounds that are caspase inhibitors.

The invention belongs to the technical field of nutrition products and particularly relates to a composition for improving glutathione concentration in a human body and a preparation method and an application thereof. The composition is composed of an A component and a gain agent, wherein the A component is composed of glutamic acid and / or glutamic acid derivatives, cystine and / or cystine derivatives, glycine and / or glycine derivatives. According to the composition disclosed by the invention, the A component is cooperatively used together with the gain agent to improve the solubility of the composition in the mouth, so as to promote the adsorption of a human body to the composition, improve the utilization rate of the composition, more effectively promote the synthesis of glutathione in vivo and improve the concentration level of the glutathione in the human body and further improve the immunity of the human body; and the composition disclosed by the invention has antioxygenation and detoxication. The combined use of the A component and the gain agent can also improve the taste of the composition, so that the composition is more suitable for direct taking of people. Since the glutathione is a very important antioxidant in the human body, and cellular oxidation is the root of aging and various diseases, the composition disclosed by the invention can be applied to prevention and auxiliary treatment of various diseases.

There is provided FV derivatives that reduce blood clotting activity, by reducing thrombin generation, when compared to wild-type FV. In particular, the FV of the present invention comprises single-point and multi-point mutations, encompassed by aspartic acid 79 to glutamic acid 119. The derivatives can be used to treat patient with conditions necessitating reduced clotting activity.

Provided is a pharmaceutical preparation that is suitable for more effectively exhibiting the efficacy of a glutamic acid derivative, which is a GGT-recognizable prodrug, by producing a composition including a glutamic acid derivative capable of rapidly releasing a physiologically active substance by being recognized by GGT, or a pharmacologically acceptable salt thereof; and a block copolymer in which a polyethylene glycol segment is linked to a polyamino acid segment with a hydrophobic group. Particularly, the composition based on a glutamic acid derivative that uses an antitumor compound as a physiologically active substance is capable of effectively accumulating the glutamic acid derivative at a tumor affected area, exhibits a superior effect against tumors, and is capable of suppressing the release of a physiologically active substance in bone marrow tissue where the expression ratio of GGT is low. Therefore, side effects such as myelosuppression, which pose a problem in the use of antitumor drugs, may be avoided.