The invention discloses a preparation method of a rare earth cerium doped thermistor material. According to the process, rare earth cerium is provided by reaction of cerium nitrate and sodium oxalate,and B value and resistivity of the original thermistor material are changed to a larger extent. The conduction principle of traditional NTC (negative temperature coefficient) thermosensitive ceramicsis the jumping conductance caused by jumping of electrons between different valence-variable ions of the same metal in the position B of a spinel structure, while Mn and Co both have various valenceions, cation distribution of Mn and Co is relatively complex, and various ions such as Mn<4+>, Mn<3+>, Co<3+> and CO<2+> may be present in the position B. Detection shows that after doping of rare earth cerium, the grain size becomes small and the grain boundary increases. In the NTC thermosensitive ceramic material, the grain is a semiconductor, and the grain boundary is a high resistance layer and is the main unit for withstanding voltage. Besides, the thermistor material obtained after doping of rare earth cerium has high stability and good aging resistance, and has greater application prospects in precision instruments such as dialyzers, DNA sequencers, blood analyzers and the like.