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354 results about "Defective virus" patented technology

Virus which lacks a complete genome so that it cannot completely replicate or cannot form a protein coat; some are host-dependent defectives, meaning they can replicate only in cell systems which provide the particular genetic function which they lack; others, called satellite viruses, are able to replicate only when their genetic defect is complemented by a helper virus.

Helper-free, totally defective adenovirus for gene therapy

InactiveUS6228646B1Encapsidation efficiencyMaximal recombinationInactivation/attenuationNucleic acid vectorIn vivoHelper virus
A method for producing in vivo packaged recombinant adenovirus vectors is provided. The recombinant Ad vectors do not contain any Adenovirus genes and are therefore useful for gene therapy. The recombinant Adenovirus vectors are packaged in vivo using a helper virus which is itself very inefficiently packaged, providing a recombinant viral preparation with very little or no contamination with helper virus. In particular, the method makes use of a helper virus in which the packaging site can be easily excised in vivo by recombination mediated by a recombinase. The helper virus is also useful for the in vivo construction of new recombinant adenovirus vectors containing substitutions in the E1 or other adenoviral region.
Owner:RGT UNIV OF CALIFORNIA
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