50 results about "Blumea riparia" patented technology

The invention provides a method for quickly cultivating Blumea riparia medicinal material, which comprises that collecting Blumea riparia explants in wild, which it contains stem sharp, young stem, old stem, blades, bulbs, and seeds, to be washed and disinfected, and using plant organism quick cultivating method and grafting cultivating method to quickly cultivate the Blumea riparia, cultivating seeds, while the obtained seed can be directly used in field. The invention has high cultivate speed, short period as 2-3 months, with high survival rate more than 90%, simple operation, simple device, low cost, and application in whole year. And the product cultivated by the invention has stable gene character, without variation.

Belonging to the technical field of traditional Chinese medicine extraction, the invention discloses a technological method for extraction of protocatechuic acid from Blumea riparia (Bl.) DC. The method for preparation of a protocatechuic acid monomer consists of: water extraction, concentration, extraction, elution, and TLC preparation and purification. A compound B is determined as protocatechuic acid with a concentration of equal to or more than 99% by HPLC analysis, and is the protocatechuic acid monomer. The technological method for extraction of chlorogenic acid from Blumea riparia (Bl.) DC solves the problems of low preparation purity, small preparation quantity, complex preparation process, and difficult realization of industrialization production. By means of water extraction, concentration, extraction, elution and other processes, high extraction purity and a simple preparation process can be realized. Thus, the method is suitable for popularization, and meets the need of people for protocatechuic acid.

The invention discloses a method for establishing an HPLC fingerprint spectrum of a Zhuang medicinal material Blumea riparia (Bl.) DC. By adopting a high-performance liquid chromatography, and using main ingredients such as protocatechuic acid and protocatechuic aldehyde of Blumea riparia (Bl.) DC as reference substances, a fingerprint spectrum of a common pattern of the Zhuang medicine Blumea riparia (Bl.) DC medicinal material is obtained. The fingerprint spectrum has 13 chromatographic peaks, can fully reflect the chemical compositions of the Blumea riparia (Bl.) DC medicinal material, and is rich in information amount, the method has good reproducibility, a more powerful theoretical basis is provided for controlling the quality of the medicinal material and identifying the advantages and disadvantages of the medicinal material, the quality control and the level of true and false identification of the Zhuang medicine Blumea riparia (Bl.) DC medicinal material are improved, and the authenticity and the advantages and disadvantages of the Blumea riparia (Bl.) DC can be quickly and accurately identified.

The invention discloses a method for preparing blumea riparia water-soluble polysaccharides. One method of the invention comprises the steps of extraction, film separation, protein removal, desalination, decoloration, refining and refining. The second method of the invention comprises the steps of extraction, film separation, protein removal, silica gel column chromatographic separation, decoloration, dialysis and refining. The method has the advantages of simple process flow, energy conservation, high product purity, stable quality and the like. The production of the invention particularly has significant hemostatic activity in blood coagulation recalcification tests and isolated uterine tests of mice.

The invention relates to an affective part of a vegetative medicine of Diangui blumea balsamifera and an extracting method thereof as well as a medicine composite containing the effective part of the Diangui blumea balsamifera. The method comprises the steps of: adopting big-pore resin to absorb, conducting ethanol grade washing and separation to obtain the total flavone extractive. The total flavone extractive of the Diangui blumea balsamifera is taken as the effective part to be solely used or used in the medicine composite for curing hemorrhage in gynae. The patient can conveniently take the medicine in small dosage reducing the per time dosage from 1g to 0.2g, moreover, the side effects are small and the curative effect is more distinct in addition that the quality is more stable. The invention is suitable for industrial production and has wide application prospect. The extraction rate of the total flavone extractive of the Diangui blumea balsamifera is 2 to 3 percent, and the content of the total flavone in the extractive is 50 to 60 percent. The products or the extractive of the invention can be made into troche, grain, oral liquid, pill, soft or hard capsule and other oral formulations by proper methods.

A Chinese medicine 'Fuxuekang' in the form of tablet or capsule is prepared from balsamiferous blumea and protocatechuic acid through extracting of balsamiferous blumea, drying, and proportionally mixing it with protocatechuic acid.

The invention discloses a rapid propagation method of a Blumea riparia (Bl.) DC medicinal material. The rapid propagation method comprises the steps: sterilizing an explant of the Blumea riparia (Bl.) DC medicinal material, inducing calluses, differentiating the calluses, proliferating multiple shoots, performing rooting culture on the multiple shoots, and transplanting tissue culture seedlings. The rapid propagation method of the Blumea riparia (Bl.) DC medicinal material disclosed by the invention is suitable for breeding and planting in a factorized scale, and has the advantages of low investment, high seedling culture speed, high survival rate, short period, consistent growth vigor of seedlings and the like, the raw material of the explant is easy to obtain, large in quantity and wide in range, the survival rate of tissue culture reaches 95%, moreover, the hereditary character is stable, the produced herbal material has stable quality, meanwhile, the Blumea riparia (Bl.) DC medicinal material is guaranteed to be stable in source, and the rapid propagation method provides a rapid and effective path to fully exert the ecological benefits and economic benefits of the Blumea riparia (Bl.) DC medicinal material in the southwest region of China.

The invention discloses a method for raising seedlings of Yunnan-Guangxi balsamiferou blumea hurb leaves by cutting. The leaves are used as materials and are treated by rooting liquid which comprises various components and a root promotion culture solution to implement cutting seedling raising. The method is easy to operate, low in cost, time-saving and labor-saving. A large quantity of high-quality seedlings which are directly used for large-field production can be produced within short time; furthermore, the seedlings are stable in hereditary character and cannot be varied; the good characters of the seedlings can be kept favorably, and the safety of the use of the seedlings is improved; extremely active effects on regeneration and continuous use of pharmaceutical plant resources can be achieved. By adopting the method, the production of Yunnan-Guangxi balsamiferou blumea herb medicinal materials is high in speed and good in effect; the number of multiplied Yunnan-Guangxi balsamiferou blumea herb seedlings obtained by seedling cutting is about 10 times that of the multiplied Yunnan-Guangxi balsamiferou blumea herb seedlings obtained by branch cutting; the transplanting survival rate is high (over 95 percent); the method can be implemented all the year round, is favorable for large-scale industrial production, is extremely high in practicability and has important practice and popularization significances for the production of the Yunnan-Guangxi balsamiferou blumea herb seedlings.

The invention discloses a new application of herba blumea riparia for treating gynecological diseases, and relates to a product prepared by raw powder of herba blumea riparia or extracts of herba blumea riparia and is used for treating female infertility. Particularly, drugs, functional foods and the like can be prepared by the raw powder of herba blumea riparia or extracts of herba blumea riparia and proper excipients or auxiliary components. The product is capable of improving ovulation of the uterus remarkably and has a good curative effect to the female infertility.

The invention discloses a process method for extracting chlorogenic acid from blumea riparia(BL.)DC, and belongs to the technology field of traditional Chinese medicine extraction process. According to the method, a chlorogenic acid monomer is prepared from the following process: water extraction, concentration, macroporous resin adsorption and separation, elution, purification, and further purification, wherein a compound C is analyzed and determined to be chlorogenic acid with the content of not less than 98.6% by HPLC and is the chlorogenic acid monomer. The process method for extracting the chlorogenic acid from blumea riparia(BL.)DC solves the problems that the preparation purity is not high, the preparation amount is small, the preparation course is complicated and industrialized production is difficult to realize; with combination of the polar macroporous resin column enrichment and a mixed solvent split-phase method, the chlorogenic acid distribution gradient purification is realized, the extraction purity is high, the process steps are simple, and the process method is suitable for industrialized production.

The invention discloses a Blumea riparia controlled release preparation and a preparation method thereof. The controlled release preparation is a preparation prepared by mixing controlled release pellets prepared by using a controlled release Blumea riparia component with a rapid release Blumea riparia component according to prescription proportions, and a mass ratio of Blumea riparia in the controlled release Blumea riparia component to Blumea riparia in the rapid release Blumea riparia component is 60:40-75:25. The preparation method of the Blumea riparia controlled release preparation comprises the following steps: 1, extracting a controlled release preparation extract dry extract powder; 2, preparing a soft material according to the controlled release Blumea riparia component; 3, preparing drug-containing pellets by using an extrusion spheronization pelletizing machine; 4, preparing the controlled release pellets through fluidized bed dressing; and 5, mixing the controlled release pellets with the rapid release component to prepare the Blumea riparia controlled release preparation. Compared with preparations in the prior art, the controlled release preparation disclosed in the invention has the advantages of administration frequency reduction, maintenance of stationary plasma concentration, prolongation of the effective menstruation hemostasis, blood circulation promotion and blood stasis removal time, side effect reduction, rapid reaching of an effective plasma concentration, safe use and deficient curative effects.

The invention discloses a method for establishing an HPLC fingerprint spectrum of a Zhuang medicinal material Blumea riparia (Bl.) DC. By adopting a high-performance liquid chromatography, and using main ingredients such as protocatechuic acid and protocatechuic aldehyde of Blumea riparia (Bl.) DC as reference substances, a fingerprint spectrum of a common pattern of the Zhuang medicine Blumea riparia (Bl.) DC medicinal material is obtained. The fingerprint spectrum has 13 chromatographic peaks, can fully reflect the chemical compositions of the Blumea riparia (Bl.) DC medicinal material, and is rich in information amount, the method has good reproducibility, a more powerful theoretical basis is provided for controlling the quality of the medicinal material and identifying the advantages and disadvantages of the medicinal material, the quality control and the level of true and false identification of the Zhuang medicine Blumea riparia (Bl.) DC medicinal material are improved, and the authenticity and the advantages and disadvantages of the Blumea riparia (Bl.) DC can be quickly and accurately identified.

The invention discloses a traditional Chinese medicine for treating thyroiditis and a preparing method thereof. The traditional Chinese medicine is prepared from, by weight, 15-25 parts of honeysuckle, 10-17 parts of solidago, 9-21 parts of blumea riparia, 3-12 parts of radix cynanchi bungei, 5-11 parts of resina toxicodendri, 9-14 parts of ricepaper pith, 3-8 parts of Indian adenosma, 5-10 parts of symplocos lancifolia, 10-17 parts of common gendarussa herb, 5-10 parts of caulis clematidis armandii, 3-9 parts of gentian, 2-7 parts of semen euphorbiae pulveratum, 1-8 parts of senecio scandens, 2-8 parts of radix berberidis, 11-16 parts of trichosanthes kirilowii maxim, and 6-19 parts of cape jasmine. According to the traditional Chinese medicine, raw materials are easy to obtain, cost is low, and treatment effect is remarkable; furthermore, purely natural crude drugs are matched, and side effects, dependency and drug resistance are avoided; treatment course is short, and the traditional Chinese medicine becomes effective quickly, has a good treatment effect and can be widely applied to prevention, control and treatment of thyroiditis.

A Chinese medicine in the form of capsule for treating menoxenia, puerperal he morrhage, acyesis, etc is prepared from balsamiferous blumea herb.

The invention relates to the field of a pharmaceutical formula, and in particular relates to a traditional Chinese medicine for treating gynecological hemorrhage. The traditional Chinese medicine is characterized by being prepared from the following crude medicines in parts by weight: 20-30 parts of wintercreeper, 10-20 parts of blumea riparia, 8-15 parts of hairyvein agrimony, 5-10 parts of iris ensata thumb, 5-10 parts of sevenlobed yam rhizome (represented in the specification), 10-15 parts of radix ophiopogonis, 10-20 parts of sanguisorba officinalis, 10-20 parts of pseudo-ginseng, 5-10 parts of perfoliote knotweed herb, 5-10 parts of folium artemisiae argyi, 5-10 parts of folium callicarpae pedunculalae, 5-20 parts of bighead atractylodes rhizome, 5-10 parts of impatiens balsamina, 5-20 parts of felwort, 5-25 parts of sargentgloryvine stem and 10-30 parts of liquorice; the 16 raw materials are soaked in water and are decocted, dregs are reserved and filtrate is reserved. The traditional Chinese medicine disclosed by the invention can be used for rapidly curing gynecological hemorrhage and prevent gynecological hemorrhage diseases, and relieving pains of a patients; the traditional Chinese medicine is free from side effect, capable of treating both symptoms and root causes, and convenient for recovery and treatment of patients of gynecological hemorrhage.

The invention provides a blumea riparia tablet, which comprises the following components: therapeutically effective amount of blumea riparia extractive, silicified microcrystalline cellulose, mannitol, polyacrylic acid resin IV, titanium dioxide, sodium carboxymethyl starch, colloidal silicon dioxide and glyceryl distearate. The invention also provides a preparation process of the blumea riparia tablet. With the same medicinal material content, the blumea riparia tablet can reduce the everyday doses of a patient. In the invention, the auxiliary materials are reasonably selected and prepared, so that the coordination role of components in the auxiliary materials can be fully played. The preparation process is simple, the process flow is short, and the production is easy.

The invention discloses a thin-layer identification method for Blumea riparia in Yixuean granules. With protocatechuic acid and protocatechualdehyde as the contrast, and a chloroform, ethyl acetate and formic acid mixed solution as a developing solvent, the method is good in separation effect, high in reproducibility and easy to implement; by means of the method, rapid qualitative analysis of Blumea riparia can be achieved, and a reliable guarantee is provided for effectively controlling the quality of Yixuean granules.

The invention discloses Fuxuekang granules and a preparation process thereof. The Fuxuekang granules comprise the following preparation raw materials in parts by weight: 500 to 2000 parts of Blumea riparia DC, 75 to 300 parts of a filling agent and a proper amount of a flavoring agent. Preferably, the filling agent comprises alpha-lactose and microcrystalline cellulose according to the weight ratio of 1:(3.5-4.5), more preferably, the filling agent comprises alpha-lactose and microcrystalline cellulose according to the weight ratio of 1:4.25. Further, the flavoring agent is cane sugar, xylitol, sorbitol, maltitol or mannitol. By adoption of a special formula and a preparation process, the obtained Fuxuekang granules have high effective component content, excellent bioavailability and storage stability.

The invention discloses a quality control method of Yixuean granules. With protocatechuic acid serving as a reference substance, high performance liquid chromatography is adopted for carrying out gradient elution, and a fingerprint spectrum of a common pattern of the Zhuang medicine Blumea riparia material is obtained. The fingerprint spectrum has 21 chromatographic peaks in total and is capable of fully reflecting the chemical components of Yixuean granules and large in information amount, and the method is high in precision, repeatability and stability and has great significance on quality control over Yixuean granules and the clinical effect of Yixuean granules.

The invention provides a tablet preparation of balsamiferous blumea leaf and branchlet by using balsamiferous blumea leaf and branchlet as the raw medicinal material, mixing with medicinal auxiliary material by proportion, preparing granule through dry method palletizing or wet method palletizing, charging lubricating agent, pressing into tablet, performing film dressing to obtain the tablet.

The invention discloses an HPLC (High Performance Liquid Chromatography) fingerprint spectrum establishment method for Yixuean granules. Protocatechuic acid is adopted as a reference, and gradient elution is performed to obtain a fingerprint spectrum of a common mode of medicinal materials of a Zhuang medicament blumea riparia by HPLC. The fingerprint spectrum has totally 21 chromatographic peaks, chemical components of the Yixuean granules can be completely reflected, the information amount is large, and the method is high in precision, reproducibility and stability and significant for quality control and clinical efficacy of the Yixuean granules.

A medicine in the form of oral liquid for treating gynopathy is prepared from the extract of balsamiferous blumea herb, cane sugar and propionic acid as aseptic.

A Chinese medicine in the form of coated tablet for treating gynopathy is prepared from balsamiferous blumea herb through decocting, filter, concentrating, drying, proportionally mixing with lactose, granulating, drying, die pressing and coating.

The invention discloses a tomato insecticide and a preparation method thereof. The tomato insecticide comprises the following compositions in parts by mass: 30-50 parts of herba andrographis, 20-30 parts of blumea riparia, 10-12 parts of pericarpium granati, 8-10 parts of herba portulacae, 3-5 parts of radix angelicae dahuricae, 20-30 parts of fructus xanthii, 2-4 parts of a material with a Chinese name of Lazipi, 30-40 parts of herba houttuyniae, 8-10 parts of herba ephedrae, 18-20 parts of geraniumwilfordii maxim, 12-14 parts of radix rhapontici, and 1750-1950 parts of water. The tomato insecticide is a plant insecticide, and has the advantages of being green, environment-friendly, free of harm to human and animals, free of drug resistance and the like.

A Chinese medicine in the form of non-sugar particles for treating gynopathy is prepared from the powdered extract of balsamiferous blumea herb and rebaudioside through proportionally mixing, granulating, and coating.

The present invention relates to a Fuxuekang Chinese medicine preparation. It is characterized by that it uses Chinese medicinal material Diagui blumea as main component with the functions of warming the middle-jiao to dispel cold and promoting blood circulation and removing blood stasis. Said invention also provides the concrete steps of its preparation process, and can be made into tablet, capsule and dripping pills, and can be used for curing the diseases of menorrhagia of woman, menostaxis and postpartum lochiorrhea, etc.

The invention relates to a traditional Chinese medicine for treating nephrotic syndrome. The traditional Chinese medicine is prepared from the following medicine materials in parts by weight: 12 parts of red gentian, 13 parts of nervilia fordii, 14 parts of herb of purpleflower asiabell, 10 parts of fruits of kwangsi Dutchmanspipe, 15 parts of carpesium cernuum, 5 parts of ajuga pantantha Hand.Mazz, 25 parts of Blumea riparia, 30 parts of omei linden root-barks, 15 parts of Mcrotis unifolia, 15 parts of Pogostemon nigrescens Dunn, 5 parts of girald pteroxygonum roots and 15 parts of themeda triandra. Clinical experiments verify that the traditional Chinese medicine provided by the invention can safely and effectively treat nephrotic syndrome when used together with hormones.

The invention discloses an HPLC (High Performance Liquid Chromatography) fingerprint spectrum establishment method for Yixuean granules. Protocatechuic acid is adopted as a reference, and gradient elution is performed to obtain a fingerprint spectrum of a common mode of medicinal materials of a Zhuang medicament blumea riparia by HPLC. The fingerprint spectrum has totally 21 chromatographic peaks, chemical components of the Yixuean granules can be completely reflected, the information amount is large, and the method is high in precision, reproducibility and stability and significant for quality control and clinical efficacy of the Yixuean granules.