1031 results about "Block group" patented technology

Compounds of the formulaeLAn-Z-X—WwD and BZ-X—WwDwherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide residue; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and / or excipient, and methods of delivery the drug D via the compounds.

The invention provides nucleoside and nucleotide molecules containing cleavable linkers linking a label such as a dye. The invention also provides nucleosides and nucleotide molecules containing a blocking group, either removable or non-removable. The invention additionally provides methods of using the nucleoside and nucleotide molecules containing a cleavable linker and / or a blocking group.

The present invention is directed to microcapsules having polymeric shells that possess blocking groups (e.g., amine-blocking groups), the removal or cleavage of which act to initiate release of the core material therein, or increase the rate at which such core material is released. The present invention is further directed to the formulation of said microcapsules in aqueous dispersions, to the preparation of said microcapsules, and to the use of such microcapsules and dispersions thereof.

Methods of producing nucleic acid molecules using an in situ nucleic acid synthesis protocol are provided. The method can comprise contacting a substrate comprising an attached blocked nucleoside monomer or polymer with a deblocking fluid to remove the blocking group, thereby generating an unblocked attached nucleoside monomer or polymer; displacing the deblocking fluid from the substrate surface comprising the attached unblocked nucleoside monomer or polymer with a purging fluid; and reacting the attached unblocked nucleoside monomer or polymer with another blocked nucleoside monomer. Nucleic acid molecules produced by the methods are also provided and can be attached to or released from the substrate (e.g., provided in solution or in a lyophilized form).

A pair of asymmetrical, partially double-stranded oligonucleotide adapters are provided wherein the pair of adapters comprise a first asymmetrical oligonucleotide adapter comprising a single-stranded 3′ overhang and a second asymmetrical double-stranded oligonucleotide adapter comprising a single-stranded 5′ overhang and at least one blocking group on the strand of said second asymmetrical oligonucleotide adapter that does not comprise the 5′ overhang. Also provided are a pair of double-stranded Y oligonucleotide adapters and a pair of double-stranded bubble oligonucleotide adapters and methods of using said asymmetrical adapters for amplification of at least one double stranded nucleic acid molecule, wherein the amplification produces a plurality of amplified nucleic acid molecules having a different nucleic acid sequence at each end are also described. Also provided is a method for exponentially amplifying one strand in a double-stranded nucleic acid molecule. Also provided are methods for preparing libraries of paired tags using COS-linkers. Also provided are cleavable adapters comprising an affinity tag and a cleavable linkage, wherein cleaving the cleavable linkage produces two complementary ends. Methods of using the cleavable adapters to produce a paired tag library are also described.

The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3′ end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein.

An emulator uses code translation and recompilation to execute target computer system applications on a host computer system. Target application code is partitioned into target application code blocks, and related target application code blocks are combined into block groups and translated. Translated application code block groups are sized to comply with restrictions on branch instruction size. Upon selecting an application code block group for execution, a cache tag is used to determine if a corresponding translated code block group is available and valid. If not, the block group is translated and executed. Sequentially executed translated code blocks are located in adjacent portions of memory to improve performance when switching between translated code blocks. The emulator may use a link register of the host computer system to prefetch instructions and data from translated code blocks. The emulator also takes into account structural hazards in translating instructions.

Provided are a method and apparatus capable of reducing a metadata processing time associated with address mapping performed to input / output burst data at a high speed in a virtual file system of a storage unit having a plurality of non-volatile data storage media. The method includes: determining a block group including a block included in each of a plurality of the non-volatile data storage media; determining an access unit including each page included in the determined block group; and mapping an address of input / output data to the determined block group and the access unit. Therefore, it is possible to significantly reduce an address mapping processing time in the virtual file system that may function as a bottleneck in high-speed input / output in a large-capacity storage unit.

The invention relates to a super-resolution method based on a single image. The super-resolution method includes the steps that S1, bicubic interpolation is carried out on the input low-resolution image to obtain an initial high-resolution image; S2, the initial high-resolution image is divided into a plurality of image blocks overlapped mutually, then a similar image block grouping is obtained, and image noise of the similar image block grouping is removed; S3, the multiple denoised image blocks are fused into a whole high-resolution image, a non-local similar image block and a weighting coefficient of each image block are solved, and the redundancy weight of a non-local similar image block grouping is calculated; S4, an on-line dictionary is updated according to the similar image block grouping and fused with an off-line dictionary; S5, the sparse representation coefficient, about a fused dictionary, of each image block is solved; S6, all the image blocks and the whole high-resolution image are reconstructed, if iterations do not converge and the number of the iterations is smaller than a preset threshold value, the previous steps are executed again, and otherwise the high-resolution image is output. The reality sense and accuracy of super-resolution reconstruction are promoted, and the super-resolution method has the advantage of removing the image noise at the same time.

A multileaf collimator includes a first leaf block group including plural leaf blocks, a second leaf block group including plural leaf blocks arranged in the same direction as the first leaf block group and disposed opposite the leaf blocks of the first leaf block group, plural magnetic layers located on the respective leaf blocks of the first and second leaf block groups so as to be positioned on faces of the leaf blocks along a moving direction of the leaf blocks, plural magnetic sensors mounted on the respective leaf blocks and varying output signals when the respective leaf blocks are moved in an oncoming direction or a departing direction, and a control device controlling drive mechanisms according to the output signals delivered by the respective magnetic sensors so that spacing between the leaf blocks of the first and second leaf blocks is adjusted into a target configuration.