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80 results about "Biological clock" patented technology
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An epigenetic clock is a biochemical test that can be used to measure age. The test is based on DNA methylation levels.
Method, apparatus and program for evaluating life styles
InactiveCN101770547APhysical therapies and activitiesLocal control/monitoringComputer scienceBiological clock
The invention discloses a method, apparatus and program for evaluating life styles. Disclosed herein is a life-style evaluation method including the steps of acquiring information on a form of a living habit prescribing a life style, obtaining a virtual biological-clock rhythm curve by reflecting the information in a reference biological clock rhythm curve on a basis of the degree of an effect given by the form of the living habit on a biological-clock rhythm curve, and setting an indicator of the life style on a basis of the virtual biological-clock rhythm curve.
Owner:SONY CORP
Advanced sleep phase syndrome gen in humans
InactiveUS20040146873A1Altered period lengthImprove mobilityCompound screeningApoptosis detectionGlycinePhosphorylation cascade
The present invention includes the disclosure of the hPER2 gene and a mutant of the hPER2 gene that participates in the human circadian biological clock. The product of the mutant hPER2 gene found in some familial advanced sleep phase syndrome patients is hypophosphorylated by casein kinase epsilon due to the serine-to-glycine mutation caused by the point mutation of the genomic sequence. Specifically, this serine-to-glycine mutation affects the casein kinase epsilon binding region of the hPER2 protein, thus blocking the phosphorylation cascade ordinarily caused by the binding of casein kinase epsilon to hPER2.
Owner:UNIV OF UTAH OF RES FOUND +1
Human body period expression gene identification method based on RNN-CNN neural network fusion algorithm
ActiveCN110111848ATo achieve the purpose of dimensionality reductionModerately change the numberBiostatisticsNeural architecturesHuman bodyData set
The invention discloses a human body period expression gene identification method based on an RNN-CNN neural network fusion algorithm. The method comprises the steps of performing missing filling andtime sequence period extension on original data, then establishing a high-quality learning dataset through a data level, performing thermal graph clustering on period expression data for preliminarilyunderstanding the specific expression of a biological clock gene in a visual sense angle, then combining a recurrent neural network algorithm and a convolutional neural network algorithm for obtaining an RNN-CNN fused algorithm by means of a deep learning algorithm, and performing periodical and non-periodical subtype classification on an RNN-CNN fused algorithm classifier and common deep learning algorithms CNN and RNN, performing cross validation on a classifying result, and performing evaluation by means of an accuracy score, a recall rate and a comprehensive evaluation index.
Owner:NANJING DRUM TOWER HOSPITAL
High-quality ecological pig feeding method
InactiveCN102388837AImprove immunityQuality improvementAnimal feeding stuffInjection antibioticLife quality
The invention relates to a high-quality ecological pig feeding method, which comprises the aspects in healthcare feed, regular feeding, ecological environment and healthy daily life. The healthcare feed is traditional Chinese medicine feed capable of promoting digestion, increasing immunity, improving feed conversion rate, improving daily weight increase and increasing pork quality, and can effectively substitute for antibiotics and hormones; and by providing cooked food, the digestion and the absorption of live pigs are facilitated, the body health of the live pigs is facilitated and the pork quality of the live pigs is improved. By letting the live pigs out of pigsties for exercise, the body health of the live pigs is improved and the possibility of antibiotic injection because of sickness is reduced. Regular feeding and healthy daily life are compliant with the rhythm of the biological clock of the live pigs, the health of the live pigs can be further improved and the pork quality is improved. By providing an ecological environment, excrements such as fetes, urine and the like can be rapidly decomposed, the pigsties are enabled to be free of pollution and smell and the living quality of the live pigs is improved.
Owner:秀山弈博农业开发有限责任公司
Infant or pet nursing method and nursing system and nursing machine adopting method
InactiveCN103985383AImprove portabilityImprove reusabilitySpeech recognitionCompanion animalComputer science
The invention discloses an infant or pet nursing method. The method includes the steps that audio signals of infants or pets are acquired; the acquired audio signals are compared with prestored standard information; translation information of the audio signals of the infants or the pets is acquired. According to the voice of the infants or the pets, the acquired audio signals are compared with the standard information in a database, languages of the infants or the pets are translated, and meanwhile through user operation, the collected information is marked, data analysis is conducted through a system, and prompt information is provided before the biological clock of the infants.
Owner:PHICOMM (SHANGHAI) CO LTD
Sleep body motion recognition method, sleep quality assessment method and smart wearable device
InactiveCN109091150AAccurate Action RecognitionGood sleep habitsDiagnostic signal processingSensorsSleep movementsBody movement
The invention provides a sleep body motion recognition method. The method comprises the steps of using an acceleration sensor to collect three-dimensional acceleration data in a plurality of body movements during sleeping of a user and processing the data to establish a plurality of standard models at a normal speed; collecting a novel sleep action of the user, and generating a test template for the sleep action of the user; determining body motions during the sleeping of the user through a DTW algorithm; obtaining the physical activity frequency of the user through the body motion of the user; combining the physical activity frequency and a subjective standard of the user to analyze and assess the sleep state of the user. The smart wearable device based on the sleep body motion recognition method or the sleep quality assessment method helps the user to calculate sleep time and body activity rules in order to better understand own biological clock, and urges the user to develop bettersleep habits, understand and grasp the rhythm of turning or activity during sleep, pay attention to physical health, and improve own result of sleep.
Owner:HUIZHOU DESAY IND RES INST CO LTD
Personal grounding device or method to ground for a human being
InactiveUS20130033121A1Reduces muscle inflammationRelieve pressureElectrotherapyEmergency protective circuit arrangementsPower gridEngineering
A personal grounding device that is used to ground a human being and provides a human being a device to directly and naturally equalize one's body to the same energy level, or potential, as the Earth. This equalization results in synchronizing the person's internal biological clocks, hormonal cycles, and physiological rhythms and in supplying the body with healing and free, positively charged electrons (called free radicals). These are abundantly present on the surface of the Earth. Electrically speaking free radicals have a positive charge. The grounding directly equalizes the body of the person to the same energy level, or potential (zero), as the Earth. The device is comprised of a closed grid (like a heating pad) in an encasement to form a mat; a lead to the grid from a ground; a ground lead (natural or artificial); and a means for connecting the field grid to the ground.
Owner:SIMPSON RUSSELL E
Ergonomic air conditioning and temperature adjustment methods
InactiveCN102287892AAdapt to the needs of natural physiological functionsAvoid harmSpace heating and ventilation safety systemsLighting and heating apparatusTemperature controlEngineering
The invention relates to an ergonomic air conditioner and a temperature adjustment method. Through the external temperature detection unit, the main unit of the air conditioner can continuously pay attention to and detect the change and rhythm of the real ambient temperature in the external nature. According to different application occasions, the present invention includes two control modes: temperature difference stabilization mode and biological clock mode. In rooms where people come and go frequently, such as shops, buses, etc., the temperature difference stabilization mode is adopted, and the temperature difference between indoor and outdoor is stable, and there will be no sudden cold or hot; With the biological clock mode, the temperature changes according to the natural rhythm, and the biological clock of the human body will not be disturbed.
Owner:熊伟鸿
Environmental light self-adaptive adjusting method used for biological clock adjusting glasses
ActiveCN104307089AIntelligent adjustmentEasy to adjustSleep inducing/ending devicesLed arrayCombined use
The invention discloses an environmental light self-adaptive adjusting method used for biological clock adjusting glasses. The environmental light self-adaptive adjusting method includes the following steps: step 1, presetting an adjusting light intensity value a; step 2, monitoring and collecting an environmental light intensity value B; step 3, calculating intensity D of light which is already used in environmental light according to a formula: D=cXB, wherein c is a constant and is determined by wave length of a used light source; step 4, calculating to acquire an intensity value of light that the light source needs to provide according to a formula: E=A-D; step 5, if a value of the E is smaller than 0, closing an LED array, and if the value of the E is larger than 0, using a method of adjusting duty ratio to adjust a light intensity value of the LED array to be E according to the value of the E. The environmental light self-adaptive adjusting method is practical and more intelligent in adjusting LED lamp intensity, a light source emitted by an LED is combined with natural light to enable an intensity value of light received by a user to be constant all the time, intensity of light needed by the user can be adjusted accurately and quickly, and the user can feel more comfortable during use, so that the biological clock of a human body can be adjusted better.
Owner:SHENZHEN QIANHAI ICECOLD IT CO LTD
Autologous/allogeneic human DNA grafting, anti-and reverse aging stem cell, and bone marrow compositions/methods
Anti-aging compositions and methods for delivering (engrafting) younger compatible human DNA to tissues, through the systematic periodic introduction of younger primordial whole (nucleated) stem cells and bone marrow into a recipient, resulting in re-establishment of an earlier relative biological clock set-point, with respect to the number of cell generations-divisions are disclosed.
Owner:HATHAWAY ALECIA A +1
Monitoring circadian activity
The invention is directed to a new method for long-term measurement of daily serotonin (5-HT) and melatonin contents in the pineal gland. The disclosed method allows visualization of the pineal gland for accurate targeting of the guide cannula which minimizes bleeding, incurs no direct injury to the surrounding brain tissue and cause no interference with the sympathetic innervation from the superior cervical ganglion. The improved method allows effects of pharmacological agents on in vivo pineal gland circulation to be studied reproducibly over time and gene expression profiles correlated with physiological consequences in the same or different individuals. More importantly, the method allows accurate assessment of the endogenous circadian clock function. The method can be used for high throughput screening to identify candidate agents which may accelerate adaptation to new time zones, to alleviate symptoms resulting from jet lag, frequent shift work sleep abnormalities and seasonal affective illnesses.
Owner:CARNEGIE INSTITUTION OF WASHINGTON
Method of differentiation induction to osteoblasts
InactiveUS7829335B2Easy to operateShort timeCulture processSkeletal/connective tissue cellsCytoplasmic transferMesenchymal stem cell
Owner:SUMITOMO ELECTRIC IND LTD
Medicinal composition of agomelatine-containing enteric capsule
InactiveCN102949376AAvoid Dissolving Absorption ProblemsOrganic active ingredientsNervous disorderBiological clockAgomelatine
The invention relates to a medicinal composition of an agomelatine-containing enteric capsule. The medicinal composition is characterized in that the composition is mainly composed of a medicine-containing part and an enteric material part. 1mg-100mg of the active component agomelatine is contained. The enteric preparation provided in the invention is used for treating depression and anxiety, adjusting sleep rhythm and regulating biological clock, and has the advantages of small main drug content and high bioavailability.
Owner:TIANJIN INSTITUTE OF PHARMA RESEARCH
Genes regulating circadian clock function and photoperiodism
Nucleic acid molecules that encode plant proteins involved in photoperiodism and circadian rhythms are disclosed. These molecules may be introduced into plants in order to alter the photoperiodic and / or circadian clock-based gene expression of the plants.
Owner:OREGON HEALTH & SCI UNIV
Medicinal composition of agomelatine-containing enteric-coated tablets
InactiveCN102824327AShort duration of actionImprove bioavailabilityOrganic active ingredientsNervous disorderActive componentAdditive ingredient
The invention relates to a medicinal composition of agomelatine-containing enteric-coated tablets. The medicinal composition is mainly composed of a medicine-containing tablet portion and an enteric coating portion, wherein the content of an active component-agomelatine is 1 mg-50 mg. The enteric-coated tablets provided by the invention can be used for treating depression and anxiety, have the functions of adjusting sleeping rhythms and biological clocks, and have the advantages of low content of the main medicine and high bioavailability.
Owner:TIANJIN INSTITUTE OF PHARMA RESEARCH
Use of arachidonic acid for normalization of infradian rhythm
InactiveUS20060073187A1Promoting actionExcellent in application to drug and foodBiocideOrganic active ingredientsArachidonic acid supplementationBiological clock
A composition having a normalizing action for infradian rhythm and / or a synchronization promoting action for circadian rhythm (biological clock) containing arachidonic acid and / or an arachidonic acid-containing compound.
Owner:SUNTORY HLDG LTD
An on-line biological water quality monitoring model based on biological rhythms of golden crucian carps and a building method thereof
ActiveCN107478791AReduce distractionsOvercome the defect that the internal mechanism of organisms cannot directly reflect the change of water qualityTesting waterWater qualityWater flow
An on-line biological water quality monitoring model based on biological rhythms of golden crucian carps and a building method thereof are disclosed. The method includes (1) selecting organisms to be tested; (2) preparing a trace pollutant solution, and determining the concentration of a medicine for tests according to surface water environment quality standards of the People's Republic of China; (3) arranging a blank group and an experimental group, with each group comprising at least three parallel groups, putting the organisms to be tested in the blank group and the experimental group into different sensors of an organism on-line behavior detector, adding aerated water into the sensors of the blank group, adding the prepared trace pollutant solution into the sensors of the experimental group, adding at least two golden crucian carps into each sensor after the aquatic organism on-line behavior detector is calibrated, performing a water flowing test, and allowing a system to automatically collect and record data; (4) performing data processing and result analyzing; and (5) building a biological clock model.
Owner:SHANDONG NORMAL UNIV
Apparatus for adjusting biological clock of a traveler
InactiveUS20050002178A1Simple and inexpensive to manufactureEasy to useLighting support devicesLighting elementsEngineeringLength wave
An apparatus for adjusting the biological clock of a traveler is constructed to has a body, which can be made in the form of an article of clothing for wear by a user or a footstool for resting the user's legs, and a light source installed in the body and used to emit light of a wavelength within about 400 nm-700 nm to irradiate a part of the body of the traveler having many blood vessels relatively close to the surface, a location at which light interacts with photoactive substances in the blood.
Owner:WU JENNY +1
Method and illuminometer of measuring illuminance of human body biological clock effect
The invention relates to a method and an illuminometer of measuring illuminance of human body biological clock effect. The method and the illuminometer of measuring illuminance of the human body biological clock effect are characterized by utilizing the visual effect relevant with working and sleeping of a human body. The method and the illuminometer of measuring the illuminance of the human body biological clock effect comprise a photometry probe (1), a photoelectricity amplifying module (2), a data processing module (3), a data locking module (4) and a number-reading displayer (5). The photometry probe (1) is composed of a cosine reviser (11), a corrector (12) matched with a visual spectral response curve of the human body biological clock effect and a silicon photocell, and therefore the measuring result is enabled to be identical to the vision sensitization of the human body biological clock effect.
Owner:CHINA JILIANG UNIV
Biological clock nerve-soothing hypnosis medicinal pillow
InactiveCN101972091AAct as a sedative and hypnoticWell-matchedPillowsNervous disorderMedicinal herbsValerian Root
The invention discloses a biological clock nerve-soothing hypnosis medicinal pillow. Chinese medicinal herbs and plant leaves are filled in the medicinal pillow. The medicinal pillow comprises the following components in part by weight: 10 to 20 parts of peanut leaf, 10 to 20 parts of sunflower disc, 10 to 20 parts of sunflower leaf, 10 to 20 parts of tuber fleeceflower stem, 10 to 20 parts of seed of wild jujube, 10 to 20 parts of valerian root and 10 to 20 parts of juncus effusus. The medicaments are compatible, coordinate yin and yang, have synergetic effect and definite curative effect, and can be widely applied to various asomnia symptoms. The medicinal pillow is convenient to use, and can be used for treatment in bed rest; and the medicinal pillow is a result researched by combining Chinese medicinal theory and biological clock effects of Chinese medicaments and plants based on years of clinical research and application, and is obtained from an effective medicinal pillow formula determined by repeated proof, screening and clinical practice. After long-term use, the medicinal pillow can fully exert the biological clock effect of the Chinese medicaments in the medicinal pillow, and achieves the effects of strengthening brain, soothing nerve, calming, accelerating sleeping and prolonging life. The medicinal pillow is widely applied to asomnia and sleep disorders caused by various reasons.
Owner:刘力争
Use of arachidonic acid for normalization of infradian rhythm
Owner:SUNTORY HLDG LTD
Method for increasing expressions of clock gene, arntl gene, and/or per2 gene by using momordica charantia extract
InactiveUS20170360864A1Improve sleep qualityImprove sleepingNervous disorderMetabolism disorderDiseaseMomordica
A method for increasing the expressions of CLOCK, ARNTL and / or PER2 genes is provided, wherein the method comprises administering to a subject in need an effective amount of Momordica charantia extract. The method is useful for treating or preventing diseases related to CLOCK, ARNTL and / or PER2 genes, or regulating physiological functions related to CLOCK, ARNTL and / or PER2 genes. The method is especially for adjusting the biological clock, improving sleep quality, and facilitating sleep.
Owner:TCI CO LTD
Construction method and application of axonal Charcot-Marie-Tooth drosophila model
ActiveCN111424053AQuick filterEasy to observeCompounds screening/testingHydrolasesDrosophila ornatifronsNervous system
The invention relates to a construction method and application of a drosophila model for simulating human diseases, in particular to a construction method and application of a drosophila model for axonal Charcot-Marie-Tooth (CMT2). The model constructs the amino acid mutation of the endogenous corresponding human ATP1A1 gene of the Drosophila by a genome editing method, and evaluates the pathological phenotype by utilizing the changes of brain nervous system loop, biological clock related behavior, life span and exercise ability. The model and the pathological evaluation means established by the invention have the advantages of simple operation and strong repeatability, and the obtained CMT2 drosophila model can be used for researching the pathological process and mechanism of the disease,can also be used for screening and verifying medicines for delaying or treating the CMT2 disease on a large scale, and has a good application prospect.
Owner:FUZHOU UNIV
Novel method for adjusting time difference reaction
InactiveCN101899494AInhibitory activityEasy to adjustMicrobiological testing/measurementVector-based foreign material introductionHuman bodyMammal
The invention discloses a novel method for adjusting the time difference reaction of the mammal, relating to a novel protein Magedl for adjusting the circadian rhythm and the mammal, wherein the novel protein Magedl plays an important part in maintaining the normal biological clock function. In a mouse with the Magedl, the core biological clock molecular amplitude of the mouse is changed to be small, the day-night cycle of the mouse is changed to be short, and the adjusting speed in the simulative time difference reaction is accelerated. Therefore, the Magedl can be taken as a drug target for curing the time difference reaction of human body.
Owner:NANJING UNIV
Gegen-qinlian decoction water extract for regulating obese body
InactiveCN110464756ALower serum triglyceride levelsAlter energy metabolismMetabolism disorderDigestive systemLow density lipoprotein cholesterolMetabolite
The invention relates to the technical field of traditional Chinese medicines, in particular to a gegen-qinlian decoction water extract for regulating an obese body. The gegen-qinlian decoction waterextract is obtained from puerarin, radix scutellariae, coptidis rhizome and radix liquiritiae through medicinal material compatibility and water decoction; the medicinal material compatibility is calculated by the following materials in parts by mass: 7-9 parts of the puerarin, 2-4 parts of the radix scutellariae, 2-4 parts of the coptidis rhizome, and 1-3 parts of the radix liquiritiae; the gegen-qinlian decoction water extract is used for preparing drugs to regulate intestinal flora and liver biological clock genes of intestine damp heat of the obese body, and has the effect of reversing Akkermansia and Lactobacillus, at the same time, the expression and transcription level of liver Clock and Arntl genes is up-regulated, the level of body serum triglyceride can be effectively reduced, and the gegen-qinlian decoction water extract has a regulatory effect on total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood glucose, insulin and other blood lipid and blood glucose indexes, and also has a regulatory effect on short chain, medium chain and long chain fatty acids, tryptophan, kynurenine, cannabinoid and other metabolites of the body.
Owner:JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
A Comprehensive Test of Multi-sport Physiological Index Weightless Aircraft
InactiveCN105380657BBioreactor/fermenter combinationsBiological substance pretreatmentsHuman bodySimulation
Owner:SCI RES TRAINING CENT FOR CHINESE ASTRONAUTS
Supervisory system for disease prevention of pigs
InactiveCN112568141AReduce labor costsMonitor vital signsDigital data information retrievalCo-operative working arrangementsWeb serviceEmergency medicine
The invention provides a supervisory system for disease prevention of pigs. The supervisory system collects body surface temperature and motion information of the pigs in real time through a data collection system, transmits the body surface temperature and the motion information to a server module through a communication base station, performs intelligent analysis in the server module, judges temperature and behaviors, and sends results to a WEB service module or an APP of a mobile phone. Therefore, a set of biological clock model is established for each pig, a health state or a disease stateof the pigs is obtained in real time, and a forecasting system for automatic body temperature and activity detection is formed; when a certain pig is abnormal, warning information is actively sent tobreeding personnel, so that the labor cost is saved for a breeding farm; and meanwhile, vital signs of the pig can be monitored around the clock, so that real-time monitoring of the pig is achieved,the breeding risk of the farm is reduced, early discovery, early prevention and early treatment of diseases are achieved, the death rate is reduced, and economic losses are avoided.
Owner:深圳市中融数字科技有限公司
Soy biological clock gene GmLCL1, encoding protein and application thereof
ActiveCN102731636AProlong reproductive periodInhibition of floweringBacteriaPlant peptidesBiotechnologyCross breeding
The present invention provides a soy GmLCL1 protein, which is: 1) a protein comprising an amino acid sequence represented by SEQ ID NO.1; or 2) a protein, wherein an amino acid sequence represented by SEQ ID NO.1 is processed by substituting, deleting, or adding one or a plurality of amino acids to form the amino acid sequence of the protein, and the protein is derived from the protein 1) and has the same activity as the protein 1). The present invention further provides a gene GmLCL1 encoding the protein. With over-expression of the gene, plant flowering can be significantly inhibited, and a growing period can be prolonged. The gene and the encoding protein can be used for solutions of problems of asynchronous flowering period in cross breeding, and growing period controls, photoperiod sensitivity and introduction of various crops, vegetables, fruits and flowers.
Owner:INST OF CROP SCI CHINESE ACAD OF AGRI SCI
Soybean biological clock gene GmFKF2, encoding protein, and applications thereof
The invention provides a soybean biological clock gene GmFKF2 protein, (1) the protein is composed of amino acid sequences represented in the SEQ ID NO.1; (2) or the protein is derived from the protein mentioned in (1) through substituting, losing or adding one or several amino acids in the amino acid sequence represented in the SEQ ID No.1, and has the same activity as that of the protein mentioned in (1). The invention at the same time provides a gene GmFKF2, which encodes the protein mentioned above, through over-expressing the gene, plant blossom can be prominently promoted, and the growth period can be prolonged. The soybean biological clock gene GmFKF2 and encoding protein thereof can be used to solve the problems of flowering asynchronism in the crossbreeding process, growth period control of various plants, vegetables, fruits, and flowers, photoperiod sensitivity, and species introduction.
Owner:INST OF CROP SCI CHINESE ACAD OF AGRI SCI
Culture method for ecological wild boars
InactiveCN106106334ARich in amino acidsRich in vitaminsFood processingAnimal feeding stuffWeight gainingDisease
The invention discloses a culture method for ecological wild boars. The method comprises following steps: (1) health-care fodder; (2) ecological environment; (3) healthy living. The culture method for ecological wild boars has following beneficial effects: based on eating habits and nutrition demands, fodders can be arranged so that good palatability, high protein content, full amino acid and rich vitamin content are obtained; immunity and disease prevention of wild boars are obtained; in addition, though weight-gaining speed of wild boars may slow down due to indoor ventilation, physical health of wild boars is enhanced so that possibilities of injecting antibiotics due to diseases is reduced; regular feeding and healthy living are compatible with rhythm of biological clocks of wild boars; health degree of wild boars is improved so that quality is improved; an ecological environment can rapidly digest and decompose excreta such as manure such that hog houses are pollution-free and odor-free so that living quality of wild boars is improved.
Owner:浏阳市大仓种养专业合作社
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