The invention discloses an intelligent cooling and heat dissipation device for a data machine room. The device comprises a heat dissipation box, an outer side of the heat dissipation box is provided with an embedded box, connecting plates are installed at the positions, close to the top, of the two sides of the embedded box, a plurality of diffusion pipes penetrate through the heat dissipation boxand the two side walls of the embedded box, and the top end of each diffusion pipe is connected with a flange plate; a plurality of sets of air supply windows are formed in the top of the heat dissipation box, a protection box is arranged in the middle of the top of the heat dissipation box, a control box is arranged at the position, close to one end, of the interior of the heat dissipation box,and a temperature sensor, a DSP and a PLC are sequentially arranged on the inner side of the control box; and an air inlet fan, a compressor, a cooler and an air exhaust fan are sequentially installedin the heat dissipation box from front to back, and one end of the air exhaust fan is connected with a connecting pipe. According to the invention, an occupied area of the machine room can be effectively reduced, meanwhile, a heat dissipation range is wide, and a good dustproof effect is achieved.