The invention discloses a motion interference detection method for a complex multi-body device, and the method comprises the steps: scanning each part of the complex multi-body device, obtaining a surface scatter model of each part, and constructing a part initial bounding box for each part based on the part scatter model; on the basis, in the interference detection operation stage, firstly, carrying out interference detection operation between every two initial bounding boxes of all components, judging whether the initial bounding boxes need to be further subdivided or not according to the operation result, if interference occurs, outputting a current result, and otherwise, subdividing the initial bounding boxes again, and carrying out pairwise interference detection operation; respectively obtaining a bounding box model binary tree of each part in the whole operation process, traversing interference detection operation layer by layer from top to bottom between every two of the component bounding box model binary trees to realize the interference detection of the complex multi-body device. According to the invention, the motion interference analysis and collision safety detectionin a motion control process can be performed on the complex multi-body device.