The invention belongs to the technical field of sensors, and discloses a multi-sensor comprehensive test system for health monitoring on bridges, towers and high-rise buildings. The comprehensive test system comprises sensors, a data acquisition device, a on-site data monitoring terminal, a network port and a remote client terminal, wherein the sensors include an acceleration sensor, a vibrating wire sensor and a full-bridge resistance strain sensor; and the vibrating wire sensor checks the full-bridge resistance strain sensor and records conditions of long-term slow sinking, force bearing and the like of buildings, and the acceleration sensor triggers and closes the full-bridge resistance strain sensor. With cooperation of the sensors at each part and an acquisition module in the system, the function of comprehensive test is realized, and by the application of the acceleration sensor, the problem that the full-bridge strain sensor is always in a high-speed acquisition state is solved, and thus the comprehensive test system can be widely used for various buildings, and can detailedly record and reflect some geological disaster information in time so as to save financial and material resources for latter health analysis.