The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy. In certain embodiments, systems and devices of the present invention find use in combination with other medical devices (e.g., surgical devices, surgical tools; e.g., hemostats, blades, scalpels). In certain embodiments, more than one energy delivery system or device of the present invention may be employed simultaneously or sequentially (e.g., for cutting and coagulation procedures).