The invention relates to a wall-mounted ventilation purifier which comprises a box body, a controller, an outdoor air duct, an outdoor air inlet, a fresh air valve, an air return vent, an air passage, a fan, purifying device sets and an air supply outlet, and is characterized in that besides the air return vent, an adjacent room air return inlet can also be formed; besides the air supply outlet, an adjacent room air supply outlet can also be formed, wherein the outdoor air inlet, the air return vent and the adjacent room air return inlet are positioned at one side of the box body, the air supply outlet and the adjacent room air supply outlet are positioned at the other end of the box body, the air passage is formed between the outdoor air inlet, the air return vent and the adjacent room air return inlet and between the air supply outlet and the adjacent room air supply outlet, the fan and the purification device sets are arranged in the air passage and are communicated mutually, and the outdoor air inlet is communicated with the outdoor air duct and the fresh air valve. The wall-mounted ventilation purifier realizes a multiple purification function of indoor and outdoor ventilation purification and indoor circulating purification (one room or two adjacent rooms).