69results about How to "High prevalence" patented technology

The invention describes formulations that include either metformin, sulfonylurea or a biguanide-sulfonylurea combination as one active ingredient in addition to specific, other active ingredients. The compositions and dosage forms of the invention are clinically useful as methods for increasing the effectiveness, efficiency and safety of the included biguanide (metformin) and / or sulfonylurea in the prevention and treatment of insulin resistance and diabetes mellitus. The carefully chosen additional active ingredients of the invention are designed in a modular fashion to prevent and rectify adverse events associated with insulin resistance syndrome and diabetes mellitus, and those adverse incidences associated with the concurrent use of metformin and / or the sulfonylureas. When clinically administered, the invention will provide therapeutic levels of metformin and of a sulfonylurea, alone or in combination, and broaden their usefulness. The invention will retard the progression of insulin resistance to type 2 diabetes, and reduce the serious microvascular and macrovascular complications commonly associated with insulin resistance syndrome and diabetes mellitus.

Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties / analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties / analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Methods and compositions for treating a subject for obesity-hypoventilation syndrome, or related conditions, are provided. The subject methods include applying an electrical stimulus to a subject in a manner that modulates chest cavity capacity in a manner effective to treat the subject. Also provided are compositions, kits and systems for use in practicing the subject methods.

A lane departure warning system (LDWS) installed on vehicles is revealed. The LDWS includes a camera that captures road images and the data of images is sent to an electronic control unit (ECU) for processing and recognition. The ECU is directly connected with a global positioning system (GPS) that provides vehicle speed signals so as to check whether dangerous driving occurs. Once the dangerous driving occurs, a warning unit is turned on to send an alert. The conventional LDWS that complicatedly connects with vehicles parts such as turn signal lights or speedometers is replaced by connection with a GPS. Thus the convenience of installation of LDWS in vehicles is improved.

A method of controlling a domestic gateway, intended to connect at least one domestic terminal of a domestic computer network to a telecommunication network. The domestic gateway includes an access point configured so as to establish a connection between the domestic terminal and the domestic gateway. Method includes: a step of verifying the state of the connection between the domestic gateway and the domestic terminal via the access point, and a step of cyclically placing the access point on standby if the connection is inactive, in which the access point is alternately enabled for a duration of activity and disabled for a duration of sleep.

An efficient method and apparatus to receive broadcasted emergency alerts using portable handheld devices or mobile devices that are operable to provide a user with relevant alerts based on the user's relevant position, in a low-powered, always-on manner are presented. Using the always on partitions of both the receiver and the system on chip (SOC) of a mobile device, embodiments of the present invention are capable of determining whether or not the remainder of the circuits of a mobile device need to be powered on in order to record audio data associated with an alert, when the alert is received. Furthermore, embodiments of the present invention are operable for displaying these alerts in a manner such that a user is notified that a relevant alert has been received and placing the user in a position where the user must address the alert notification and take appropriate action.

The present invention provides a means for prevention and treatment of sarcopenia by administration of a substance that both reduces the sensibility of beta-adrenergic receptors and of 5-HT1a receptors. (S)-pindolol, (S)-propanol, tertalol, or bopindolol are preferred for this purpose.

A monitoring station system and method for monitoring multiple dial-up points in a communications network, such as an Internet or intranet site. A single monitoring station runs dial monitor processes that can concurrently establish connections to, and test multiple dial-up points of, the site. Test data regarding availability and response time of the dial-up points can be obtained. Additionally, a transaction monitor process may run as a parent process of the dial monitor processes. The transaction monitor process provides service-specific monitors that use the established connections to the dial-up points to test services offered by, or via, the site, such as DHCP, HTTP and others. A different service of the site can be tested via each different connection. Specific testing is performed based on a profile that is tailored to customer needs. The connections may be established via analog modems, DSL modems, or ISDN terminal adapters / modems.

Compositions and methods for the culturing, propagation, cryopreservation and manipulation of neural progenitor cells (NPC) and pluripotent stem cells (PSC) are provided. The cells exhibit rapid doubling times and can be maintained in vitro for extended periods. Also provided is a method of propagating neural progenitor cells, and a method of transplanting human NPC and / or PSC to a host. The cells can be genetically modified to express a therapeutic agent prior to the transplanting.

A foamable polymeric mixture is provided that includes a polymer composition and at least one blowing agent. The blowing agent may comprise any blowing agents known not to deplete the ozone or increase the prevalence of global warming, such as CO2, HFO, HFC and mixtures thereof. The foamable polymeric mixture may further includes at least one processing aid comprising an organic phase changing material. The inventive foamable mixture is capable of processing at a pressure range of 800 to 1200 psi (5.5 to 8.3 MPa).

A method for creating personal authentication keys includes the steps of determining a number of RFID tags, generating a key, partitioning the key into a number of parts, the number of parts corresponding to the number of determined RFID tags, and writing each of the plurality of key parts to a corresponding RFID tag.

Compositions and methods for the culturing, propagation, cryopreservation and manipulation of neural progenitor cells (NPC) and pluripotent stem cells (PSC) are provided. The cells exhibit rapid doubling times and can be maintained in vitro for extended periods. Also provided is a method of propagating neural progenitor cells, and a method of transplanting human NPC and / or PSC to a host. The cells can be genetically modified to express a therapeutic agent prior to the transplanting.

The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.

An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.

The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.

A lane departure warning system (LDWS) installed on vehicles is revealed. The LDWS includes a camera that captures road images and the data of images is sent to an electronic control unit (ECU) for processing and recognition. The ECU is directly connected with a global positioning system (GPS) that provides vehicle speed signals so as to check whether dangerous driving occurs. Once the dangerous driving occurs, a warning unit is turned on to send an alert. The conventional LDWS that complicatedly connects with vehicles parts such as turn signal lights or speedometers is replaced by connection with a GPS. Thus the convenience of installation of LDWS in vehicles is improved.

Methods and kits for assessing severity index for alcohol abuse, drug abuse, and other reward deficiency syndromes. It has been discovered that a multifaceted non-specific RDS behaviors should be considered as the true “reward” phenotype (endophenotype) instead of a single subset RDS behavior such as alcoholism. In an embodiment of the present invention, it has been discovered that there are at least eleven risk alleles associated with ten candidate genes. The methods and kits of the present invention satisfy the need to classify patients at genetic risk for drug / alcohol seeking behavior prior to or upon entry to residential and or non-residential chemical dependency and pain programs.

The invention relates to application of an artemisia leaf extract, and in particular relates to application of an artemisia leaf extract in a medicament for treating pulmonary heart diseases and a preparation method of the artemisia leaf extract. The invention discloses the application of the artemisia leaf extract in preparing the medicament for treating the pulmonary heart diseases. The pulmonary heart diseases have the characteristics of high epidemicity, high morbidity rate, high death rate and high cost, and surveys show that the morbidity rate of people living in rural areas in northern China is 0.44%, therefore, the development of a pulmonary heart disease Chinese traditional medicine treatment medicament with a definite curative effect, a reasonable cost and sufficient supply of goods is of great significance. Meanwhile, the traditional Chinese medicament namely artemisia leaf is further developed and studied, and is finally pushed to the market, which also is one of important paths of realizing modernization of Chinese medicaments.

Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties / analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

An isolated polysaccharide has the structure [-β(1,3)-D-GalpNAc-β(1,4)-D-Glcp-]n The polysaccharide may be from a Bifidobacterium strain NCIMB41003. The polysaccharide exhibits immunomodulatory activity.

The invention belongs to the field of pharmaceutical preparation, particularly discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis and intestinal metaplasia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials: codonopsis pilosula, stir-fried rhizoma atractylodis macrocephalae, rhizoma pinellinae praeparata, poria cocos, pericarpium citri reticulatae, hedyotis diffusa, mica atba, rhizoma curcumae and radix curcumae; the preparation method comprises the steps of water extraction, alcohol precipitation, spray drying and addition of auxiliary materials, therefore various preparations are obtained, and the functions of invigorating spleen, supplementing qi, regulating qi-flowing for harmonizing stomach, and improving and resisting gastric mucosal atrophy and intestinal metaplasia are achieved, besides, the invention further discloses the application of the traditional Chinese medicine composition to preparation of drugs used for treating chronic atrophic gastritis and intestinal metaplasia.

This invention provides methods of treating and preventing diseases or conditions of the immune system or infectious disease, involving administration of vitamin D and / or one or more antioxidants (e.g., vitamin E and / or zinc).

The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of said neuronal cells and cell population.

A method for creating personal authentication keys includes the steps of determining a number of RFID tags, generating a key, partitioning the key into a number of parts, the number of parts corresponding to the number of determined RFID tags, and writing each of the plurality of key parts to a corresponding RFID tag. This method for personal identification may also provide either primary or secondary personal access to a physical device or customized presentation within an entertainment or informational system, such as commerce or financial systems.

Methods, reagents and compositions thereof for predicting RA onset in susceptible individuals, diagnosing RA onset, and / or evaluating efficacy of a therapeutic regimen for treating RA are described herein. Determining the amount of a particular bacterial species comprising SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3 (SEQ ID NO: 1+bacteria) serves as a biomarker for the above indications.

The invention relates to a method for detecting KLK1gene rs5517 polymorphism relating to essential hypertension. The method includes detecting A / G polymorphism located at 3812 bp of KLK1 gene coding sequence, in which, the distributed frequency of allele A has positive correlation with the risk rate of essential hypertension. The invention also involves the kits to detect rs5517 polymorphism of KLK1 gene.

The invention relates to the technical field of planting, in particular to a planting method of high-quality red pitaya. The planting method comprises steps as follows: (1) cutting planting; (2) management in the growth period; (3) management in the flowering period; (4) management in the fruiting period and the like. Disinfection and disease removal are performed on soil by spraying traditional Chinese medicine water during cutting planting, the used traditional Chinese medicine water cannot cause residues and is safe and environment-friendly, growth hormone is smeared on trunks of pitaya during topping in management in the growth period, knife edges can be effectively disinfected, growth of lateral shoots can be promoted, and the fruit setting rate can be increased by cross pollination in management in the flower period, so that the purposes of high disease resistance, high fruit setting rate, good quality and no residues are achieved.