The invention relates to the technical field of protective package, and particularly discloses a packaging box with a protection function in the transporting process. The packaging box comprises a packaging box body and a protection air bag, the protection air bag is arrange don the inner side wall of the packaging box body in a surrounding manner, an air leakage hole is formed in the protection air bag, an air supply device for supplying air for the protection air bag is arranged on the inner side wall of the packaging box body and comprises a cylinder and a piston which are slidably connected, a brake handle is fixedly connected at one end, close to outer side wall of the packaging box body, of the piston, a reset spring is arranged between one end, far away from the brake handle, of thepiston and the cylinder, an air outlet and an air intake are formed in one side of the cylinder with the reset spring and positioned on one side, far away from a handle, of the piston, an air outletone-way valve is arranged on the air outlet, an air intake one-way valve is arranged on the air intake, an air inlet is formed in the protection air bag and communicated with the air outlet. By the aid of the packaging box, clay figurines can be clamped to prevent collision in the transportation process, and the ventilation conditions of the peripheries of the clay figurines can further be improved.