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44results about How to "Affect survival" patented technology

Compounds for the treatment of inflammation and neutropenia

The present invention concerns compounds modulating apoptosis of neutrophil cells. In particular, the invention concerns compounds inhibiting an interaction between Proliferating Cell Nuclear Antigen (PCNA) and proteins binding to cytoplasmic PCNA in neutrophil cells, for use in the treatment of a disease involving a neutrophil-dependent inflammatory process. The invention also relates to a method for the identification of a compound for use in the treatment of a neutrophil-dependent inflammatory process. The invention further relates to peptides for use in the treatment of neutropenia.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)

Lipid transport protein inhibitor, application thereof and antibacterial drug

InactiveCN111632148AAffects transport efficiencyAffect survivalAntibacterial agentsOrganic active ingredientsLipid TransportAnti bacterial
The invention provides a lipid transport protein inhibitor, application thereof and an antibacterial drug. The target of the lipid transport protein inhibitor is located at one or more amino acid sites in a MlaFEDB protein complex; preferably, the target of the lipid transport protein inhibitor is located on at least one of MlaD protein, MlaF protein and MlaE protein. According to the invention, key amino acid sites participating in phospholipid transport in the MlaFEDB protein complex are studied, and it is found that multiple amino acid sites in MlaD protein, MlaE protein and MlaF protein play a key role in phospholipid transport, Once the functions of the amino acids are destroyed, the phospholipid transport efficiency can be remarkably influenced, and then bacterial survival is influenced. Therefore, development of antibacterial drugs by taking the amino acids as targets has very important significance.
Owner:SICHUAN UNIV

Cll1-specific multi-chain chimeric antigen receptor

The present invention relates to a new generation of chimeric antigen receptors (CAR) referred to as multi-chain CARs, which are made specific to the antigen CLL1. Such CARs aim to redirect immune cell specificity and reactivity toward malignant cells expressing the tumor antigen CLL1. The alpha, beta and gamma polypeptides composing these CARs are designed to assemble in juxtamembrane position, which forms flexible architecture closer to natural receptors, that confers optimal signal transduction. The invention encompasses the polynucleotides, vectors encoding said multi-chain CAR and the isolated cells expressing them at their surface, in particularly for their use in immunotherapy. The invention opens the way to efficient adoptive immunotherapy strategies for treating cancer, especially leukemia.
Owner:CELLECTIS SA

System for regulating loach water quality in high-salt planting and breeding mode

The invention discloses a system for regulating the loach water quality in a high-salt planting and breeding mode. The system comprises a high-salt planting and breeding pool, a sun shield, bases, natural plant planting pots, a sandstone plate, a microbial incubator, a thermometer body, a camera body, a regulation system control panel, a connecting column, an oxygen extractor body, a regulation system control shell, a water quality sensing module, an information receiving module, an information processing module, an information storage module, a GPS positioning module and an instruction outputmodule, the sandstone plate is arranged on the inner wall of the bottom of the high-salt planting and breeding pool, a plurality of mounting grooves are formed in the top of the sandstone plate, natural plant planting pots are arranged at two sides of the top of the sandstone plate, and the microbial incubator is arranged at the center of the top of the sandstone plate. The system for regulatingthe loach water quality in the high-salt planting and breeding mode abandons traditional manual monitoring, adopts machine monitoring to achieve time and labor saving and convenient and accurate monitoring, and allows a user to regulate the water quality according to the observation result in order to facilitate user operation.
Owner:无锡三智生物科技有限公司

Device for preventing feed mildewing in frankliniella occidentalis feeding process and use method

The invention relates to a device for preventing feed mildewing in the frankliniella occidentalis feeding process and a use method. The device comprises a groove-type box body (1) with an open top, and a handle (5) is arranged on the outer side wall of the box body (1); fine sand (3) is laid in the box body (1), filter paper (4) is laid on the fine sand (3), and a green beam frame (2) is arrangedon the filter paper (4). The device has the advantages of being easy to operate, reasonable in design and capable of saving manual labor force and improving the breeding efficiency, in the process ofstudying the frankliniella occidentalis control problem in our country, a large number of indoor populations can be propagated rapidly for a laboratory to use, and the device can be applied and popularized in all research institutes and colleges and universities.
Owner:YUNNAN AGRICULTURAL UNIVERSITY

Srp54k gene, and application of specific dsRNA of srp54k gene to plagiodera versicolora prevention

The invention provides a srp54k gene, and application of specific dsRNA of the srp54k gene to plagiodera versicolora prevention. On the basis of a sequence of the plagiodera versicolora srp54k gene, abacterial expression vector capable of expressing and targeting dsRNA of the gene is constructed, and the plagiodera versicolora is killed with poison through bacteria-expressed and bacteria-targetedthe dsRNA of the srp54k gene and spraying bacteria onto leaf surfaces. The dsRNA gene is high in silencing efficiency, has an obvious phenotypic change after being interfered, solves the problem thatthe plagiodera versicolora does not have effective dsRNA of the srp54k gene at present, and has a better application prospect in research and development of novel insecticides.
Owner:HUBEI UNIV

animal feeding device

The invention discloses an animal feeding device. The animal feeding device comprises a rearing cage, a placement rack and an independent air supply device, wherein the independent air supply device comprises an air supply device and a delivery pipeline, and a frame is arranged on the placement rack and comprises a moving rack and a fixed rack; a plurality of driving assemblies for enabling the moving rack to move are arranged on the placement rack; a sliding groove is formed in the placement rack; first sliders sliding in the sliding groove are arranged on the moving rack, and a rotating block is arranged on the placement rack; each driving assembly comprises an outer driving rod, an inner driving rod and a first spring, the inner driving rod and the outer driving rod are in sliding connection, a first annular groove is formed in the outer driving rod, the inner driving rod and the first spring are both located in the first annular groove, one end of the first spring is fixedly connected with the bottom of the first annular groove, and the other end is fixedly connected with the inner driving rod; when the rotating block moves in the circumferential direction, the rotating block drives the outer driving rods to move, so that the inner driving rods drive the first sliders to slide in the sliding groove; meanwhile, when the first sliders move, the direction of the moving rack keeps unchanged.
Owner:WENZHOU MEDICAL UNIV

Skin-whitening melatonin facial mask and preparation method thereof

The present invention belongs to the field of facial masks and particularly discloses a skin-whitening melatonin facial mask and a preparation method thereof. The skin-whitening melatonin facial maskcomprises essence liquid, a mask paper and a packaging bag; and the essence liquid is composed of deionized water, a moisturizer, a skin-whitening ingredient, an antioxidant, an anti-inflammation ingredient, xanthan gum and a pH regulator. The present invention also discloses the preparation method of the facial mask and also discloses the packaging bag used for packaging the facial mask. The preparation method can effectively solve a problem of Vc failure, also solves a problem that faces must be cleaned before use of the facial mask, thus eliminates melanin in time and protects the skin to the utmost.
Owner:蔡先民

Precise seedling feeding device for mechanically-transplanted large-bowl blanket-shaped seedlings

The invention belongs to the technical field of agricultural instruments, and particularly relates to a precise seedling feeding device for mechanically-transplanted large-bowl blanket-shaped seedlings. The precise seedling feeding device comprises a main body, a seedling storage box used for storing materials is arranged at the upper end of the main body, a seedling pushing block used for pushing the materials is arranged at the upper end of the seedling storage box, and a seedling feeding groove used for limiting is further formed in the upper end of the seedling storage box. A rectangular groove used for collecting sundries is formed in the seedling feeding groove, the seedling storage box is connected with a square block at the lower end through an internal material distributing device, a material conveying rack used for feeding is arranged at the square block, and one end of a fourth transmission gear is connected with a seedling transplanting device through a tooth groove by arranging a third transmission gear, and the other end of the fourth transmission gear is connected with the material conveying rack through the tooth groove. According to the precise seedling feeding device for the mechanically-transplanted large-bowl blanket-shaped seedlings, by means of the arrangement, transmission of the material conveying rack and a transmission rod is mutually connected, the operation speed of the transmission rod and the material conveying rack is synchronously adjusted through control of a motor at the position, then the seedling transplanting distance is adjusted, effective adjustment can be conducted according to different seedlings, and the using effect of the precise seedling feeding device for the mechanically-transplanted large-bowl blanket-shaped seedlings is improved.
Owner:JIANGXI ACAD OF AGRI SCI INST OF AGRI ENG

Animal feeding device

The invention discloses an animal feeding device. The animal feeding device comprises a rearing cage, a placement rack and an independent air supply device, wherein the independent air supply device comprises an air supply device and a delivery pipeline, and a frame is arranged on the placement rack and comprises a moving rack and a fixed rack; a plurality of driving assemblies for enabling the moving rack to move are arranged on the placement rack; a sliding groove is formed in the placement rack; first sliders sliding in the sliding groove are arranged on the moving rack, and a rotating block is arranged on the placement rack; each driving assembly comprises an outer driving rod, an inner driving rod and a first spring, the inner driving rod and the outer driving rod are in sliding connection, a first annular groove is formed in the outer driving rod, the inner driving rod and the first spring are both located in the first annular groove, one end of the first spring is fixedly connected with the bottom of the first annular groove, and the other end is fixedly connected with the inner driving rod; when the rotating block moves in the circumferential direction, the rotating block drives the outer driving rods to move, so that the inner driving rods drive the first sliders to slide in the sliding groove; meanwhile, when the first sliders move, the direction of the moving rack keeps unchanged.
Owner:WENZHOU MEDICAL UNIV
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