38 results about "Vibrational spectrum" patented technology

CMP pad conditioning processes have been monitored and controlled by detecting the vibrational spectrum of a sensor mounted on the conditioner support arm. An accelerometer is used as the detector so that vibrational velocity (which correlates with pad wear) can be measured, rather than displacement or acceleration. After the vibrational spectrum has been transformed to its frequency domain equivalent, it is monitored for the presence of abnormal peaks in order to control the conditioning process.

The invention discloses a laser confocal/differential confocal Raman spectrum vibration parameter measurement method, and belongs to the technical field of optical precision measurement. Confocal vibration detection, differential confocal vibration detection and Raman spectrum detection technologies are fused, nondestructive separation is carried out on Rayleigh light and Raman scattered light byutilizing a dichroic light splitting system, spectrum detection is carried out on the Raman scattered light, and vibration parameter detection such as amplitude and frequency is carried out on the Rayleigh light. Therefore, the vibration information testing method capable of simultaneously detecting the vibration parameters of the sample micro-area and the Raman spectrum of the vibration of the sample micro-area is formed. According to the invention, the confocal Raman microscope and the differential confocal Raman microscope have the capability of simultaneously detecting micro-area vibrationparameter information and the Raman spectrum of micro-area vibration. The method has the advantages of high vibration measurement precision, wide amplitude measurement range, high frequency measurement bandwidth, high spectrum detection sensitivity, capability of measuring periodic motion and aperiodic motion, high environmental interference resistance and the like. Meanwhile, high-precision detection of micro-area vibration parameters and vibration spectral characteristics is carried out, and the method has a wide application prospect in the technical field of optical precision measurement.

The invention is directed to a method for non-invasive determination of the potential presence of one or more loss-of-function mutation(s) in the gene encoding for filaggrin.

The method of the invention comprises

• (i) obtaining a vibrational spectrum from the stratum corneum of the individual;
• (ii) determining the local natural moisturising factor content from the vibrational spectrum;
• (iii) optionally repeating steps (i) and (ii); and
• (iv) comparing the local natural moisturising factor content of the individual to a reference value,
• wherein said stratum corneum is stratum corneum of a location of the body of said individual at which said one or more loss-of-function mutation(s) in the gene encoding for filaggrin has a stronger influence on the natural moisturising factor concentration than other factors influencing the natural moisturising factor concentration.

The invention provides a method that gives direct information about the intervention of a potential drug on the secondary structure distribution of a targetbiomolecule, i.e., for a disease with misfolded protein, such as neurodegenerative diseases in a complex body fluid. The secondary structural change is monitored by vibrational spectroscopy. The method can be applied for prescreening of drug candidates for targeting of specific biomolecules. The effect of the drug on the secondary structure distribution is monitored label-free in real time and provides thereby direct information about the efficacy of the potential drug.

The invention relates to a method for rapid nondestructive test of irradiated food. The method comprises the following steps: (1) terahertz refractive index spectrum data of a sample to be tested are acquired; (2) characteristic data R1 and R2 which are respectively corresponding to a characteristic frequency v1 and a characteristic frequency v2 are extracted from the terahertz refractive index spectrum data; (3) characteristic values including v1, v2, R1 and R2 are calculated, and whether the sample is irradiated food is judged according to the characteristic values. The rapid nondestructive test method of the irradiated foodstuff extends applications of vibrational spectrum to the field of deteriorated foodstuff identification; the method has the characteristics of fast analysis speed, high accuracy, high working efficiency, environmental protection without pollution, and the like; the method provides powerful guarantee and technical support of rapid nondestructive identification of deteriorated foodstuff, and has active effects and reference meanings for guarantying quality and safety of foodstuff, promoting healthy development of foodstuff market, researching and developing rapid nondestructive testing instruments, and other aspects.

The present disclosure relates to automated systems (200) and methods for quantitatively determining a fixation duration of a biological specimen using a trained fixation estimation engine (210). In some embodiments, the trained fixation estimation (210) engine includes a neural network. In some embodiments, the trained fixation estimation (210) engine includes a supervised classifier.

The invention belongs to the electrochemistry technical field and relates to an electrochemical working electrode engraved with a metal nano grating and a preparation method of the electrochemical working electrode. At present, people's understanding of electrochemical reactions at the molecular level is still very insufficient, they still face a tough challenge in obtaining intermediate products,and the configurations and orientations of chemical bonds in a reaction process. The infrared vibration spectroscopy is the most effective technique to acquire molecular level information in chemicalanalysis, however, infrared light is strongly attenuated in an electrode and an electrolyte, and as a result, it is difficult to measure an infrared spectrum. According to the electrochemical workingelectrode engraved with the metal nano grating provided by the invention, a momentum is compensated by the grating, so that incident infrared light can be coupled into surface plasmons which can be propagated on an interface and have a strong near-field enhancement effect, and therefore, the absorption of the infrared light by the metal electrode and the electrolyte can be offset, field strengthat the electrochemical interface can be enhanced considerably, and thus, the acquisition of a molecular vibrational spectrum in an in-situ and real-time reaction process on the electrochemical interface can be realized.

The present disclosure relates to automated systems and methods for predicting an expression of one or more biomarkers in a sample of a biological specimen. In some embodiments, the sample is one which has an unknown fixation status, or one where the duration of fixation to which the sample was subject is unknown. In some embodiments, the predicted expression is a quantitative estimation of the percent positivity of one or more biomarkers. In other embodiments, the predicted expression is a quantitative estimation of the staining intensity of one or more biomarkers. In some embodiments, the systems and methods utilize a trained biomarker expression estimation engine which has been trained with a plurality of training samples, where the trained biomarker expression estimation engine is adapted to derive biomarker expression features from the sample.

The present disclosure relates to automated systems and methods for quantitatively determining an unmasking status of a biological specimen subjected to an unmasking process (e.g. an antigen retrieval process and/or a target retrieval process) using a trained unmasking status estimation engine. In some embodiments, the trained unmasking status estimation engine comprises a machine learning algorithm based on a projection onto latent structure regression model. In some embodiments, the trained unmasking status estimation engine includes a neural network.