The invention discloses a management method for comprehensive prevention and control of grape vine diseases and insect pests. Including the following steps: land management, pruning, tree management, fertilization management, drug control. The invention effectively reduces the invasion of fruit tree pests, greatly improves the yield and quality of grapes, provides a good growth environment for the growth of grape trees through land management and pruning, and reduces the probability of pest invasion to a certain extent. The three steps of management, fertilization management, and drug control scientifically and effectively combine physical control, biological control, and chemical control to comprehensively control plant diseases and insect pests in the grapevine planting process, which is worthy of promotion and application.