36 results about "Serum iron tests" patented technology

Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of anemia and anemia of inflammation.

The invention discloses a thiazolidone compound, wherein a chemical structure of the thiazolidone compound is shown in a general form (I). The invention also discloses application of the thiazolidone compound in preparation of a medicine used for treating thalassemia. Experiments prove that the thiazolidone compound can be used for effectively stimulating expression of hepcidin in cells under the condition that concentration is 10mu M, can be still used for effectively inducing expression of hepcidin in liver when being exposed for 6 hours, 24 hours and 48 hours respectively at a dosage of 30mg / kg in animal level and can be also used for effectively reducing level of serum iron, so that the thiazolidone compound can take hepcidin as a target, can be used for reducing iron level in serum, is hopeful to be a potential medicine used for treating and alleviating iron disorder-related diseases and has a broad clinical application prospect and a great economic development value.

The invention discloses a kit for measuring serum iron. The kit contains reagent R1 and reagent R2; the reagent R1 is composed of buffer, ascorbic acid, interference removing agent, stabilizer, surfactant and preservative; the reagent R2 The invention contains the following components: a buffer solution and saphenanthroline; and also relates to a preparation method and application of a kit for measuring serum iron. The stable serum iron of the present invention is a liquid double reagent, which does not need to be redissolved for preparation, and can be used directly after opening the bottle. By adding a stabilizer to the reagent R1, it is beneficial to maintain the stability and reducibility of ascorbic acid. Reagent R1 is added with interference removing agent, and thiourea is mixed with ascorbic acid solution, which can be used as reducing agent and masking agent to remove the interference of other ions. This reagent has higher sensitivity. The reagent is convenient to use, has high specificity, high accuracy, and has no pollution to biochemical instruments, which is conducive to the further promotion of the reagent in the market.

The invention discloses a medicine application of iron liposome. By taking animals with chronic inflammation as a model, a brand-new medicine which treats anaemia caused by the dysfunction of the iron absorption of the small intestine to relevant protein molecules and takes the iron liposome as an effective component is provided. The invention takes white rats with inflammatory anaemia as a model, adopts an oral stomach infusion method and compares the curative effect of the iron liposome for the anaemia with that of a chalybeate which is not enveloped by the liposome, and the iron liposome can obviously enhance the levels of the hemoglobin, the blood cell volume, the serum iron and the saturation rate of the transferrin of an organism in a short time, can act as a very good curative effect to the inflammatory anaemia and can not cause injuries to the health of the organism. The iron liposome is obviously superior to the traditional iron-replenished preparation. The invention can be used for treating the anaemia caused by the dysfunction of the iron absorption of the small intestine to the protein molecules because of various known or unknown reasons. Various tablets, capsules, dripping pills, oral liquid and food additives which are taken orally and contain the iron liposome are prepared.