Pharmaceutical preparation used for iron-deficiency anemia and preparation method thereof

A technology for iron-deficiency anemia and pharmaceutical preparations, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of unsatisfactory effects of iron-deficiency anemia, loss of active ingredients of polysaccharides, and increase of raw material costs, etc. , to achieve the effect of simple and feasible preparation method, high polysaccharide extraction efficiency, and shortened extraction time

Inactive Publication Date: 2017-12-08
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The applicant's previous patented technologies 2008101590994 and 2015101684898 both involved the improvement of Compound Hongyi Oral Liquid. Among them, the patented technology 2008101590994 involved the improvement of the extraction process. Through the improvement of the extraction process of different raw materials, the efficacy of the drug was improved. However, the peanut red coat Higher amounts of proanthocyanidins, resveratrol, etc. can be obtained through the process, but it is not easy to use the above process for medlar and jujube, which will cause the loss of active ingredients of polysaccharides, and the effect on iron deficiency anemia is not ideal; patented technology 2015101684898 Added a variety of Chinese herbal medicine costs on the basis of the existing formula, but this method greatly increased the cost of raw materials

Method used

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  • Pharmaceutical preparation used for iron-deficiency anemia and preparation method thereof
  • Pharmaceutical preparation used for iron-deficiency anemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A preparation method for a pharmaceutical preparation for iron deficiency anemia, comprising the steps of:

[0024] 1) Take 100g of seaweed, crush it, put it into an ultrasonic extraction tank, add twice the weight of 70% (v / v) ethanol, control the temperature at 50-60°C, and extract with ultrasonic frequency 50KHz for 90-120min, filter and collect the filtrate , vacuum rotary evaporation to recover ethanol, then concentrate the raffinate under reduced pressure to a paste of 1.2g / ml, add 10 times the weight of water, stir evenly, then add an equal volume of 5% trichloroacetic acid, let stand for 6h, Collect the supernatant by centrifugation, add absolute ethanol to make the alcohol content reach 80%, let it stand overnight, wash the precipitate with absolute ethanol, and dry to obtain 10.3g of ultraviolet extract with a sugar content of 94.1%;

[0025] 2) Take 20g fungus, add 16 times the weight of water, soak for 30 minutes, heat to a slight boil for 2 hours, filter, a...

Embodiment 2

[0035] Effects of extraction process on effective substances of polysaccharides from Lycium barbarum and Jujube:

[0036] Taking Comparative Example 1 as an example, the process of Lycium barbarum and Jujube was respectively used in Comparative Example 1, and the content of polysaccharide was determined by the phenol-sulfuric acid method, and the influence of different processes on the yield of polysaccharide was detected; see Table 1 for details:

[0037] Table 1

[0038]

Embodiment 3

[0040] Toxicity test:

[0041] In this experiment, healthy SD rats were used, and the dose gradients of the pharmaceutical preparations prepared in Example 1 were administered orally at 1ml / kg and 5ml / kg, administered continuously for 45 days, and observed during the administration of the rats and 1 week after drug withdrawal. Animal growth status, activity diet, hematology, blood biochemistry, organ tissue structure and urine routine were not significantly affected, indicating that the clinical medication is safe and reliable.

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Abstract

The invention belongs to the technical field of pharmaceutical extraction and discloses a preparation method of a pharmaceutical preparation used for iron-deficiency anemia. The preparation method comprises the following steps: 1) preparing a porphyra extract; 2) preparing agaric extracting solution; 3) preparing a fructus lycii extract; 4) preparing a Chinese date extract; 5) preparing peanut skin extracting solution; and 6) boiling, filtering, subpackaging and sterilizing. The pharmaceutical preparation can obviously improve contents of red blood cells, hemoglobin and serum iron, has the effect obviously better than that of the prior art and can be further applied to clinical experimental study.

Description

technical field [0001] The invention belongs to the technical field of medicine extraction, and in particular relates to a medicine preparation for iron deficiency anemia and a preparation method thereof. Background technique [0002] Iron deficiency anemia refers to a small cell hypochromic anemia caused by insufficient iron storage in the body, which affects the synthesis of hemoglobin. The main causes of iron deficiency anemia are as follows: ① Weakness of the spleen and stomach The function of the spleen and stomach is weakened due to improper diet, damage to the spleen or stomach or weak spleen and stomach, or damage by the seven emotions, depression and anger damage the liver, and worry damage the spleen. Affects the absorption of the essence of water and valleys, causing the blood to be passive. ②. Blood syndrome Long-term chronic blood loss due to yin deficiency and blood heat, or failure of Qi to absorb blood or spleen not controlling blood. ③. Insufficiency of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P7/06
CPCA61K36/04A61K36/07A61K36/48A61K36/725A61K36/815A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 林凡儒林祥宇郭增光付君叶罗晓倩
Owner XIANGYU PHARMA
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