Kit for detecting ultra-early Parkinson's disease

A Parkinson's disease and reagent kit technology, which is applied in biological testing, measuring devices, and disease diagnosis, can solve problems such as low sensitivity, large patient damage, and difficulty in collecting cerebrospinal fluid, so as to facilitate clinical promotion and improve sensitivity and specificity , extract and detect convenient and simple effects

Pending Publication Date: 2020-08-14
AFFILIATED HOSPITAL OF NANTONG UNIV +1
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main disadvantages of detecting PD protein biomarkers in cerebrospinal fluid are: 1) the collection of cerebrospinal fluid is difficult, which causes great damage to patients, and it is generally difficult for patients to accept it clinically; 2) there is a lack of protein markers for early warning and diagnosis...

Method used

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  • Kit for detecting ultra-early Parkinson's disease
  • Kit for detecting ultra-early Parkinson's disease
  • Kit for detecting ultra-early Parkinson's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] according to figure 2 Experiment with the technology roadmap shown.

[0028] 1. Assay Preparation

[0029] Blood samples were drawn from 35 clinically suspected patients with early PD, and the serum was collected by centrifugation for detection with the kit; finally, the accuracy of the kit was compared comprehensively according to the diagnostic criteria of MDS Parkinson's disease and the results of imaging MRI.

[0030] 2. Kit detection

[0031] The test kit of the present invention comprises a box body, an openable box cover and a reagent bottle, and the reagent bottle is fixed in the box body by foam. The reagent bottle is a sealed and sterile flat-bottomed reagent bottle, and the reagent bottle is respectively equipped with α-synuclein detection unit, serum iron detection unit, serum zinc detection unit, GSH detection unit, GSH-Px detection unit and SOD detection unit. unit.

[0032] α-synuclein detection unit includes standard (α-synuclein sample), standard d...

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Abstract

The invention discloses a kit for detecting ultra-early Parkinson's disease, and belongs to the technical field of biological detection. The kit comprises an alpha-synuclein detection unit, a serum iron detection unit, a serum zinc detection unit, a GSH detection unit, a GSH-Px detection unit and an SOD detection unit. According to the kit, serum alpha-synuclein, metal ions Fe and Zn and GSH, GSH-Px and SOD are detected, related indexes of PD are comprehensively and jointly detected, the kit can be effectively used for auxiliary diagnosis of the ultra-early Parkinson's disease, and the sensitivity and specificity of auxiliary diagnosis are improved. Meanwhile, a required sample is blood, and compared with cerebrospinal fluid extraction and detection, the kit is more convenient and simplerand is more beneficial to clinical popularization.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a kit for ultra-early detection of Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is the most common degenerative movement disorder of the central nervous system and the second most common neurodegenerative disease in the world after Alzheimer's disease. The clinical manifestations of Parkinson's disease mainly include motor symptoms such as resting tremor, muscle rigidity, bradykinesia, and abnormal posture and gait, in addition to non-motor symptoms such as depression, sleep disturbance, constipation, and cognitive impairment. According to epidemiological statistics, there are about 2.5 million PD patients in my country, and the prevalence rate of people over 65 years old is 1700 / 100,000, and it increases with age. According to the prediction of the World Health Organization experts, by 2030, Chinese PD patients will accoun...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/573G01N33/58G01N33/53
CPCG01N33/6893G01N33/573G01N33/58G01N33/5308G01N2800/2835G01N2333/47G01N2333/90283
Inventor 沈丽华孙江萌王国华骆倩倩胡佳楠
Owner AFFILIATED HOSPITAL OF NANTONG UNIV
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