37 results about "Selective cytotoxicity" patented technology

Enhancers which preferentially increase the transcription of cis-linked coding sequences in prostate cells are provided. Methods of using DNA constructs comprising the enhancers to control transcription of heterologous polynucleotides are also provided. Delivery vehicles comprising the enhancers and methods of using the vehicles are also provided. Adenovirus vectors in which one or more genes are under transcriptional control of the enhancers of the invention are also provided. Further provided are methods of using the adenovirus vectors of the invention to confer selective cytotoxicity in mammalian cells.

The invention herein describes a procedure for organically extracting the lipophilic components from plants of the Family Euphorbaciae, specifically but not limited to the genus Croton. The extraction (CGO 110), is deplete of the normal proanthocyanidin content found in the parent material, yet retains its pharmacocological abilities and unlike the parent material, is selectively cytotoxic to cancer cells. The depletion of the proanthocyanidin components makes the product more amenable to preparations for the benefit of ameliorating both human and animal disease.

The presently claimed subject matter provides conditionally replication competent adenoviral vectors that confer selective cytotoxicity on cells expressing HIF-1 by infecting cells that allow HIF-1 inducible promoters present within the vectors to function. Also provided are compositions and host cells based upon the vectors, as well as methods of propagating and using the vectors. The presently claimed subject matter further provides a method of inhibiting tumor growth by co-infecting cells in a tumor with a conditionally replication competent adenovirus vector in conjunction with a replication deficient adenovirus vector.

This invention encompasses an expeditious method and compositions that have been found to show selective cytotoxicity against several different cancer cell lines. for treating a wide variety cancer neoplasms that have tumor microenvironments by administering a stand-alone anti-tumor chemotherapeutic composition or administered as an adjunct with chemotherapy and/or radiotherapy with enhanced tumor site affinity that preferentially elevates the pH at the tumor site to suppress and eliminates the acidic tumor microenvironment, administered as chemosensitizing and/or radiosensitizers enhancing the tumor, suppression, remission and inhibit tumor metastisis. The invention encompasses controlling mechanisms of intracellular and extracellular ionic physiology through the administration of alkali salts for pH modulating and for restoring and enhancing ionic physiology. The compositions are useful in effective treatment of cancers, particularly malignant melanomas and squamous cell carcinomas (SCCs), thereby inhibiting angiogenesis, reducing metastatic proliferation, supressing tumor generated induced acidotic pain.

The invention discloses a hybrid subtype tumor targeted nano-micelle and a purpose thereof. The micelle is obtained through mixing and self assembly of a polymer 1 and a polymer 2, wherein the hydrophilic ends of the polymer 1 and the polymer 2 are respectively L-valine-L-valine dipeptide and raloxifene-modified polyethyleneglycol embedding sections; the hydrophobic end is polymer histidine or polymer lactamine. The micelle belongs to a kind of nano-micelle based on PepT1 and ER as the target, and can coat hydrophobic anti-tumor medicine; in-vitro study shows that the stability of the micelle is obviously superior to non-hybrid micelle; meanwhile, the type of nano-micelle medication system can be selectively taken by PepT1 and ER high-expression tumor cells; the tumor cells shows selective cell toxicity, and can be applied to preparation of tumor targeted treatment medicine.

The invention relates to an antitumor composition based on hydrophobized hyaluronan and inorganic nanoparticles stabilized by oleic acid. The hydrophobized hyaluronan in the form of an acylated hyaluronan serves in the composition as a carrier of inorganic nanoparticles. Out of the group of inorganic nanoparticles, the composition may comprise superparamagnetic nanoparticles, nanoparticles of ZnO and moreover, upconversion nanoparticles. Said composition is selectively cytotoxic with respect to both suspension and adherent tumor cell lines, especially with respect to tumor cell lines of colorectum carcinoma and adenocarcinoma, lung carcinoma, hepatocellular carcinoma and breast adenocarcinoma. The highest cytotoxic effects were observed in case of the composition based on an oleyl derivative of hyaluronan with SPIONs. The composition of acylated hyaluronan with SPIONs may also be advantageously used for an in vivo detection of accumulation of the composition in the body, preferably in a tumor or in liver. Said composition is sterilizable in the final package.

The invention provides a mica two-dimensional nanosheet as a drug carrier, and a preparation method of a mica two-dimensional nanosheet drug carrier containing a drug component. The low long-term toxicity, good biocompatibility and good biodegradability of mica are used, so that the mica two-dimensional nanosheet drug carrier containing a drug component can reduce multidrug resistance and systemictoxicity, and has pH-responsive drug release and selective cytotoxicity. Compared with a non-exfoliated mica powder, the mica two-dimensional nanosheet drug carrier containing a drug component has asmaller particle size, and is more easily swallowed by tumor cells.

To conduct a search for natural drugs and their formulae derived from natural substances that hardly cause side effects and drug tolerance, based on quite a new idea having departed from conventional drugs such as Chinese galenicals, Chinese medicine formulae, etc. and to develop a composition that has an anticancer activity and is selectively cytotoxic to cancer cells. A composition having an anticancer effect is obtained, which comprises therapeutically effective amounts of a dry product of Angelica keiskei and a dry product of Theaceae Camellia. Also, a composition having an anticancer activity is obtained, which comprises therapeutically effective amounts of a dry product of Angelica keiskei and/or a dry product of Theaceae Camellia together with a dry product of defatted whole egg of eggs of a fowl bred by feeding a feed having blended therein an additive comprising a dry product of Angelica keiskei, a dry product of brown algae, and optionally a dry product of Theaceae Camellia.

A substituted benzene propylene derivative and the salt are provided, which is that the phenylacrylate substituted by the corresponding group gains the correspondingly substituted phenylallyl compound through the deoxidization of the lithium aluminium hydride and the aluminium trichloride compound. The invention has certain selective cytotoxicity activeness compound from the natural erucic based alcohol compound and has low toxic effect on the normal cells, while the compounds reconstructed by structure and the important midbodies all have better cytotoxicity activeness and can be prepared in the drugs preventing and curing the tumor diseases. The prepared drugs contain the drug excipients or carriers allowed by the preparation. The drug preparation is in a form of liquid, solid, aerial fog spray, drop, gelatin pearl, nano, controlled release and sustained-release preparation. The compound related to by the invention has simple synthetic method and lower cost, therefore having feasible marketalization prospect. The invention has the above general formula.