Orally
deliverable dual-release pharmaceutical suspensions, having a first portion comprising an
immediate release form of the active in the solution form or granules or suspended form in the vehicle / medium preferably in the solution form and a second portion comprising a sustained-release form of active in the form of microgranules / microparticles suspended in the
immediate release fraction of the solulabilised
active agent which comprise a core and at least one coat suitable for liquid dosage forms for the administration of the active ingredients, wherein the core comprises at least one
active agent(s) or its pharmaceutically acceptable salts, derivatives, isomers, polymorphs, solvates, hydrates, analogues, enantiomers, tautomeric forms or mixtures thereof; optionally at least one
water insoluble, and optionally one or more pharmaceutically acceptable
excipient(s); and at least one coat comprising at least one
pH independent water-insoluble
polymer(s) along with one or more pharmaceutically acceptable
excipient(s). This coated microparticles and solution of the
active agent in the vehicle ensures a
dual release profile i.e.
immediate release profile as well as predetermined sustained release profile of the active agent and also ensures maintenance of said release profile over time. The present invention can be administered either in the form of
ready to use suspension or in the form of
powder ready for reconstitution. Further, this invention provides process of preparation of such suspensions and method of using them.