52 results about "Non conservative" patented technology

In some embodiments, the illustrative method defines an engine cycle comprising several state changes that allow for a net gain of energy from an underlying source force field. The potential for a net energy gain via the method results from the discovery that a Casimir force system can be rendered non-conservative. This is done by appropriately altering one or more of a variety of physical factors that affect the Casimir force, or by altering any of a variety of environmental factors that affect such physical factors. In various embodiments, the extracted energy is stored, used to power energy-consuming devices or used to actuate a micromechanical device. In one embodiment, the method is implemented using an energy extraction apparatus that comprises two spaced Casimir force-generating boundaries that are operatively coupled to an energy transformation system. The energy transformation system includes a first device that is operable to alter at least one physical factor of the system. The energy transformation system also includes a second device that is operable to change the distance between the two Casimir force-generating boundaries, and further operable to maintain the distance between the boundaries while the first device alters the physical factor.

Novel antagonists of CXCR3-binding CXC chemokines, and in particular of human CXCL11, can be obtained by generating mutants of such chemokines in which the binding to glycosaminoglycans (GAGs) is impaired due to non-conservative substitutions of amino acids involved in this interaction. Compounds prepared in accordance with the present invention can be used to block the activity of CXCR3-binding CXC chemokines on CXCR3-expressing cells, thereby providing therapeutic compositions for use in the treatment or prevention of diseases related to excessive activated T cells migration, such as graft rejection and autoimmune diseases, and of diseases needing an increase of vascularization, such as ischemic heart disease.

Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

The invention discloses a method for obtaining drain basin unit lines by utilizing complete two-dimensional shallow water equation sets. According to the method, a hydrological problem is solved by utilizing a hydrodynamic way. The method comprises the following steps of: firstly discretizing a two-dimensional shallow water equation set to establish a high-resolution two-dimensional shallow watermathematic model, so as to ensure that the two-dimensional shallow water model is capable of correctly simulating slope runoff processes; carrying out elevation assignment and roughness factor assignment by adoption of a triangular unstructured grid division calculation area; in order to avoid the problem of non-conservative drainage basin outlet water yield caused by drainage basin depression impounding, setting continuous time interval net rainfall processes as model input conditions; setting a drainage basin outlet as a free falling outflow condition; carrying out two-dimensional shallow water mathematic model calculation after setting a drainage basin initial state; after the calculation is ended, enabling a flow process at the drainage basin outlet as an S curve of the drainage basin;and obtaining a time interval unit line of the drainage basin by utilizing a conversion formula. The method is capable of covering the shortages of existing hydrological methods, and providing a newway for flood confluence analysis and calculation of regions without hydrological data.

The oral efficacy of C—C chemokines containing a dibasic site in the 40's conserved cationic sequence, such as RANTES and MIP-1β, is improved by substituting at least one of the residues in the dibasic site in a non-conservative manner.

Mutants of specific CC-chemokines containing a non-conservative substitution in a conserved consensus sequence act as CC-chemokine antagonists, and can be effectively used in the treatment of autoimmune and inflammatory diseases, cancers, and viral or bacterial infections. Particularly preferred are the RANTES / CCL5 mutants having the amino acid sequence of SEQ ID NO: 1, 2, 3, or 4.