The present invention provides antibodies that immunospecifically bind to a polypeptide of a mammalian
metapneumovirus, compositions comprising said antibodies, and methods for producing such antibodies. In particular, the invention provides
monoclonal antibodies that immunospecifically bind to the
F protein of human
metapneumovirus and that neutralize human
metapneumovirus. The invention also provides antibodies that cross-react with both the
F protein of a mammalian metapneumovirus and the
F protein of a mammalian respiratory syncytial
virus and that neutralize both viruses. Further, the invention provides
recombinant antibodies, such as humanized antibodies, against mammalian metapneumovirus, and methods for producing such
recombinant antibodies. The invention further provides methods for treating, managing, ameliorating symptoms of and / or preventing infections with mammalian metapneumovirus, such as human metapneumovirus. The invention also provides antibodies that immunospecifically bind the F
protein of avian
pneumovirus. Antibodies that immunospecifically bind the F
protein of avian
pneumovirus are useful in the diagnosis and treatment of infections with avian
pneumovirus.