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49 results about "Functional selectivity" patented technology

Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor. Functional selectivity can be present when a receptor has several possible signal transduction pathways. To which degree each pathway is activated thus depends on which ligand binds to the receptor. Functional selectivity, or biased signalling, is most extensively characterized at G protein coupled receptors (GPCRs). A number of biased agonists, such as those at muscarinic M2 receptors tested as analgesics or antiproliferative drugs, or those at opioid receptors that mediate pain, show potential at various receptor families to increase beneficial properties while reducing side effects. For example, pre-clinical studies with G protein biased agonists at the mu opioid receptor show equivalent efficacy for treating pain with reduced risk for addictive potential and respiratory depression. Studies within the chemokine receptor system also suggest that GPCR biased agonism is physiologically relevant. For example, a beta-arrestin biased agonist of the chemokine receptor CXCR3 induced greater chemotaxis of T cells relative to a G protein biased agonist.

Secure file system server architecture and methods

A data server platform includes a security file system layer interposed between the platform operating system kernel and file system. The secure file system layer is structured to implement a file access control function that selectively constrains data transfer operations initiated through the operating system kernel by an application program to transfer file data through the file system with respect to a persistent data store. A file access controller, implemented independent of the operating system kernel, is coupled to the security file system layer and supports the file access control function by defining permitted file data transfers through the file system. Management of the file access controller separate from the data server platform ensures that any security breach of the platform operating system kernel cannot compromise the function of the security file system layer.
Owner:THALES DIS CPL USA INC

Sheet registration within a media inverter

InactiveUS20060214364A1Enhancing document controlReducing transport path distanceRegistering devicesFunction indicatorsEngineeringFunctional selectivity
Parallel printing systems and methods incorporate inverter assemblies for not only inverting media during transport through the system but also to register the media and to provide a velocity buffer transport with different drive velocities. The inverter assemblies can include the capability to optionally deskew the media while providing lateral (cross-process) registration corrections. The method comprises simultaneously combining the inverting function selectively with deskewing, side registering, and / or velocity buffering functions.
Owner:XEROX CORP

Mobile location based service system and method

The present invention discloses a mobile location based service system and method. The mobile location based service system includes an application server for receiving a location based service request, and providing a location based service of a mobile station, and a location information providing system for discriminating location of the mobile station according to a kind of a location information service, and transmitting the location of the mobile station to the application server. A cell or GPS based location based service can be selectively provided according to a function of a mobile station of a mobile communication subscriber and a service request type. The GPS based location based service can be provided by an SMS delivery point to point message through an N07 signal network, and thus embodied during a voice call of the mobile station.
Owner:SK TELECOM CO LTD

Functionally selective alpha2C adrenoreceptor agonists

InactiveUS20080027100A1Minimizing adverse side effectReduce usageBiocideSenses disorderAdrenergicAdrenergic receptor agonists
In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
Owner:MERCK SHARP & DOHME CORP +1

Selective muting of applications

Methods, computer program products, and electronic devices are provided for managing sound in a plurality of computer-executed applications. One method includes: operating a sound manager function to provide a user with an option to selectively mute up to n−1 applications of n applications, where n>1; and in response to the user choosing to selectively mute up to n−1 applications, the sound manager function selectively muting the up to n−1 applications. Another method includes providing a user with an option to selectively mute up to n−1 applications of n applications, where n>1. In response to the user choosing to selectively mute up to n−1 applications, at least one action is performed in response to requests to play sounds by the selectively muted applications so that the sounds are muted with respect to a sound device.
Owner:TWITTER INC

Structure for connecting a combination lamp

An insulation displacement connector (40) selectively effects insulation displacement of required conductive paths of a flat cable (30) in correspondence with the function of a bulb socket connector (20). Further, the other unnecessary conductive paths are passed through without being subjected to insulation displacement connection. In addition, as the insulation displacement connector (40) and a socket housing with a bulb (21) fitted thereto are engaged, insulation displacement terminals and bulb conductor portions of the bulb (21) are electrically connected directly.
Owner:YAZAKI CORP

Method and system for dynamic debugging of software

A method for inserting a branch instruction at an instrumentation location within a running code on a target device, the branch instruction being used execute a separately compiled instrumentation code from the running user code, exposing at least one interface corresponding to at least one callable function, and connecting the separately compiled instrumentation code to the selected at least one interface, wherein the at least one callable function executes within the separately compiled instrumentation code. A debugging system having a plurality of callable functions, each callable function selectively exposing an interface, a receiving function receiving a call to one of the interfaces, wherein the call is received from a separately compiled instrumentation code being executed within a running user code a target device, and an output function receiving output based on the callable function corresponding to the one of the interfaces and the running user code.
Owner:WIND RIVER SYSTEMS

Functionally selective alpha2C adrenoreceptor agonists

In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.
Owner:MERCK SHARP & DOHME CORP +1

Novel Functionally Selective Ligands of Dopamine D2 Receptors

The present invention relates to novel functionally selective ligands of dopamine D2 receptors, FIG. 1 including agonists, antagonists, and inverse agonists. The invention further relates to the use of these compounds for treating central nervous system disorders related to D2 receptors.
Owner:THE UNIV OF NORTH CAROLINA AT CHAPEL HILL

Aircraft ground lift dump flight control function

A flight control system for an aircraft includes at least one flight control computer that carries out a ground lift dump function that selectively extends a spoiler located on a wing of the aircraft into an airflow passing over the wing. The at least one flight control computer includes arming logic that is responsive to an input signal indicative of an aircraft parameter to automatically arm the ground lift dump function during certain phases of operation of the aircraft. The at least one flight control computer includes spoiler deployment logic that is responsive to an arming signal from the aiming logic which indicates that the ground lift function is armed to deploy the spoiler into its extended position within the airflow passing over the wing of the aircraft to assist in stopping the aircraft while the aircraft is on the ground.
Owner:AIRBUS CANADA LLP +1

Adjustable slide-action stock for firearms

InactiveUS20160273875A1Comfortably practice rapid fire shootingImprove usabilityButtsEngineeringFunctional selectivity
A slide-action stock assembly for a semi-automatic firearm enables adjustment of the trigger pull length. An adjustable length interface interconnects a commercial off-the-shelf shoulder stock with a conjoined pistol grip and finger rest into a handle unit that slidably supports the firing unit portion of the firearm. The adjustable length interface includes a stem that is constrained to back-and-forth movement within a stem channel under the buffer tube. The stem includes a row of holes into which a plunger of the adjustable shoulder stock is set by the user to achieve a desired trigger pull length. A lock-out feature selectively impedes the slide-action mode. The finger rest can be positioned on either the right or left side of the pistol grip.
Owner:SLIDE FIRE SOLUTIONS

Method of taking a picture when a memory of a digital camera is already full

A method of taking a picture when the memory of a digital camera is already full, includes: judging whether the memory of the digital camera is full; if yes, allowing the digital camera to continue to take a picture; next, storing the picture in an SDRAM or a DDR SDRAM of the digital camera; next, determining whether to retain the picture by using a preview function of the digital camera; if yes, selectively deleting a part of data that is stored in the memory, via a browsing function of the digital camera, for sparing the memory a predetermined space; and, storing the picture in the predetermined space. Hence, the method solves the problem that when the memory is full and the user wants to take another picture, old pictures must firstly be deleted. Hence, the user often loses the chance to take a picture that he / she wants.
Owner:PREMIER IMAGE TECH

Source driver and charge sharing function controlling method thereof

The invention discloses a source driver, which comprises a driving unit and a data analysis unit, wherein the driving unit drives a display panel according to a video signal; and the data analysis unit is coupled with the driving unit and enables or disables the charge sharing function of the driving unit according to an analysis result. Therefore, the charge sharing function is selectively enabled in different charge sharing periods. Compared with the prior art, the source driver can lower power consumption and working temperature.
Owner:HIMAX TECH LTD

Dopamine d2 receptor ligands

The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopammode inergic activity. The present invention relates to novel compounds that modulate dopamine D2 receptors. In particular, compounds of the present invention show functional selectivity at the dopamine D2 receptors and exhibit selectivity downstream of the D2 receptors, on the 0-arrestin pathway and / or on the cAMP pathway.
Owner:THE BROAD INST INC +1

Transaction case

A transaction case performs multiple functions related for protecting a communication device and consolidating transaction data from at least one specific payment card onto a universal payment card. A housing receives the communication device. A compartment stores items. A cover opens and closes over the compartment with a lock having a wallet for holding items. A payment card slot holds universal payment cards. The universal payment card uses the transaction data from the specific payment card to perform transactions. The universal payment card utilizes security features selectively moving the universal payment card in position to perform transactions. An electromagnet connects to a spring-loaded lever controlling movement of the universal payment card. A secret code must be input to generate a signal for interfering with the magnetic field, such that the universal payment card to be released from the slot for use. A power source powers the case.
Owner:BROWAND JOSEPH B

Systems and methods for management and dissemination of information from a controlled environment facility

Dissemination of information from a controlled environment facility employs facility information management functionality managing resident information and facility information, and call manager functionality selectively providing at least a portion of the resident information and / or the facility information to an outside party and / or professionals associated with the facility in an automated manner. The invention may employ outgoing IVR functionality to provide select portions of the resident information to appropriate professionals at the time of intake of a new resident. The invention may conduct a reverse auction among professionals offering a particular good or service, manage information related to providers of services or goods for residents of a facility, provide an outside party this information including results of a reverse auction, and notify a selected provider of selection of that provider by the outside party to provide goods or services for a resident.
Owner:SECURUS TECH LLC
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