In a multiple projectile launcher system, cartridges are securely held within a cassette that can be loaded into a locking and priming mechanism in a base of a multiple projectile launcher. Once the cassette is loaded into the locking and priming mechanism, the cartridges in the cassette may be primed by moving the locking and priming mechanism (which is holding the cassette) such that electric igniter contacts in the launcher base are in contact with electric igniters at the priming end of each cartridge. Once the cassette is locked (thereby priming the plural cartridges held in the cassette), the cartridges may be fired singly, severally, and / or all at the same time, using an electrically initiated fire control system. The multiple projectile launcher is particularly effective in crowd and / or riot control, where the payload of the cartridges comprise non-lethal and / or less-lethal munitions, such as tear gas grenades, sting-ball grenades, flash-bang rounds, bean bags, etc.