The invention discloses a power supply circuit suitable for aerospace application. The circuit comprises a voltage input end, a 12V linear voltage stabilization block, a 5V linear voltage stabilization block, a 12V power utilization unit and a 5V power utilization unit, the circuit also comprises a power resistor, a current sampling circuit and a voltage comparator circuit, wherein the power resistor is used for limiting the current of a post-stage circuit, the current sampling circuit is used for collecting voltage at two ends of the power resistor and outputting sampling voltage after amplification, and the voltage comparator is respectively connected with the output of the current sampling circuit and preset reference voltage, compares the sampling voltage with the reference voltage andoutputs TTL level signals. According to the invention, the problem that the linear voltage regulator module does not meet the first-level derating requirement of aerospace parts is solved, the problem that the voltage regulator module is heated seriously is improved, and the problem of how to protect and detect when a single event locking effect occurs to a part of parts of a circuit is solved. And compared with a DC / DC voltage stabilizer module, the size is smaller, the weight is lighter, the cost is lower, and the space environment adaptability is better.