36 results about "Chronic alcoholism" patented technology

Chronic alcoholism is a diverse and heterogeneous disorder that can be dichotomized into cognitively intact and cognitively impaired subgroups. At a molecular level, ethanol has been shown to have both acute and chronic effects on: Membrane biophysical properties, Membrane composition and metabolism, Protein phosphorylation, Lipid metabolic signaling, Lipoprotein transport of cholesterol. Actual molecular underpinnings are determined for cognitive impairment seen in some chronic alcoholism subjects including molecular / metabolic alterations of phospholipid and ganglioside metabolisms.

The invention belongs to the technical field of medicine, and relates to a Chinese medicinal composition, in particular to a Chinese medicinal composition for treating chronic alcoholic toxic liver disease and a preparation method thereof. Aiming at the current technological defects that the chronic alcoholic toxic liver disease cannot be treated comprehensively and effectively and chemical treatment has the defects of high relapse rate and discontinuous curative effect, the Chinese medicinal composition for treating or preventing the chronic alcoholic liver toxic disease comprises the following components in parts by weight: 10 parts of corydalis tuber, 15 parts of fourstamen stephania root, 6 parts of virgate wormwood herb, 10 parts of glossy privet fruit, 10 parts of Szechuan lovage rhizome, 6 parts of Chinese angelica, 20 parts of sophora flower, 20 parts of tribulus terrestris, 10 parts of Chinese thorowax root, 12 parts of baikal skullcap root, 15 parts of baikal skullcap root, 30 parts of cassia twig, 6 parts of Indian buead and 10 parts of liquoric root. The Chinese medicinal composition has a very good treatment effect on the chronic alcoholic toxic liver disease, and has a remarkable clinical popularization value.

The invention relates to the medical field, and discloses a liver-protecting composite. The raw materials comprise one of S-ademetionine, cysteine or methionine, vitamin C, flower of kudzuvine, hovenia dulcis thumb and rhizoma alismatis. The invention also provides a preparation method of the liver-protecting composite. The liver-protecting composite is taken after drinking, thus being capable of preventing chronic alcoholism and alcoholic cirrhosis; and the liver-protecting composite can be taken for a long term as a liver-protecting health care product, thus having wide application prospects.

The invention provides a drug for relieving body injury caused by chronic alcoholic poisoning. The drug comprises an effective ingredient of AOAA (aminooxyacetic acid). Learning and memory ability evaluation is performed on chronic alcoholic poisoned rats and normal rats by use of a Y-type electric maze by establishing a rate chronic alcoholic poisoning model. Experimental results prove that compared with normal control groups, the chronic alcoholic poisoning model group of rats has remarkably reduced learning and memory ability. After AOAA intervention is given, the training times required for rats of a remedy group to learn spatial discrimination are reduced, and difference has statistical significance. Accordingly, AOAA can relieve memory deterioration caused by the chronic alcoholic poisoned rats, improves the learning memory ability and provides a scientific basis for research of chronic alcoholic poisoning injury mechanism and treatment by AOAA.

The invention discloses an application of a chimaera phantasma extract in the preparation of drugs for treating alcoholic brain damage. The chimaera phantasma extract is extracted from soft bones of chimaera phantasma. The chimaera phantasma extract can increase the activity of SOD and GSH-PX in the brain tissues of rats, which have chronic alcoholism, at the same time, reduces MDA and beta-EP in brain tissues, and protects the damaged brain of alcohol poisoned rats. The extract can be made into a plurality of dosage forms, and can be used as a protective agent for alcoholic brain damage.

The invention belongs to the technical field of medicine, and relates to a Chinese medicinal composition, in particular to a Chinese medicinal composition for treating chronic alcoholic toxic liver disease and a preparation method thereof. Aiming at the current technological defects that the chronic alcoholic toxic liver disease cannot be treated comprehensively and effectively and chemical treatment has the defects of high relapse rate and discontinuous curative effect, the Chinese medicinal composition for treating or preventing the chronic alcoholic liver toxic disease comprises the following components in parts by weight: 10 parts of corydalis tuber, 15 parts of fourstamen stephania root, 6 parts of virgate wormwood herb, 10 parts of glossy privet fruit, 10 parts of Szechuan lovage rhizome, 6 parts of Chinese angelica, 20 parts of sophora flower, 20 parts of tribulus terrestris, 10 parts of Chinese thorowax root, 12 parts of baikal skullcap root, 15 parts of baikal skullcap root, 30 parts of cassia twig, 6 parts of Indian buead and 10 parts of liquoric root. The Chinese medicinal composition has a very good treatment effect on the chronic alcoholic toxic liver disease, and has a remarkable clinical popularization value.

The invention belongs to the technical field of medicine, relates to a traditional Chinese medicine composition, and in particular relates to a traditional Chinese medicine composition for treating chronic alcoholic toxic liver disease and a preparation method thereof. Aiming at the current technical defects of lack of comprehensive and effective treatment on the chronic alcoholic toxic liver disease, easiness in relapse of chemical treatment, and inconstant curative effect, the invention provides the traditional Chinese medicine composition for treating chronic alcoholic toxic liver disease. The traditional Chinese medicine composition comprises the following components: 10 parts of rhizoma alismatis, 15 parts of Fourstamen Stephania root, 6 parts of herba artemisiae, 10 parts of fleece-flower root, 10 parts of rhizoma ligustici wallichii, 6 parts of angelica, 20 parts of hovenia dulcis, 20 parts of Chinese gall, 10 parts of radix bupleuri, 12 parts of rhizoma polygonati, 15 parts of Scutellaria baicalensis, 30 parts of Lycium barbarum L., 6 parts of Poria cocos, and 10 parts of liquorice. The traditional Chinese medicine composition has a very good treatment effect in the treatment of chronic alcoholic toxic liver disease, and has significant clinical promotion value.

The invention discloses a one-step synthesis method of medicinal metadoxine. The method comprises the steps that vitamin B6 is adopted as a starting raw material and directly reacts with L-pyroglutamic acid after alkali dissociation to obtain metadoxine through one-step synthesis. The proper solvent, the reaction raw material ratio and the proper reaction temperature are adopted, the medicinal metadoxine with the stable crystal form, the good flowability and high purity can be produced industrially without recrystallization or purification, the preparation steps are simplified, operation is easy, the solvent usage amount is decreased, and the production cost is saved. The medicinal metadoxine can be used for treating acute and chronic alcoholism and alcoholic liver diseases.

The invention relates to a butylphenyl phthaleine, a medical salt thereof or an application of a medical compound which contains any one of the butylphenyl phthaleine and the medical salt thereof in preparing a medicament for preventing or treating chronic alcoholism. The medicament or medical compound is characterized by being efficient, harmless and free from addiction in the application of preventing or treating the chronic alcoholism.

The invention discloses the application of total triterpenoids of Pteridocarpus to protect chronic alcoholic liver injury, and belongs to the technical field of biomedicine. A dose-escalating drinking method was used to simulate the process of chronic alcohol-induced liver injury in humans. The total triterpenoids of Pteridocarpus can inhibit GOT and GPT to a certain extent, and the inhibitory effect is positively correlated with the dose. The purified total triterpenoids of Viburnum fern have strong antioxidant capacity in vivo, and its hepatoprotective mechanism may be to effectively alleviate the damage caused by alcohol to the liver by enhancing the body's antioxidant capacity and effectively removing unfavorable free radicals. Medium and high doses of purified total triterpenoids of Viburnum fern can effectively alleviate the oxidative damage caused by lipid peroxidation and free radical attack in the liver, reduce the degree of hepatocyte enlargement, necrosis and fatty degeneration, and regulate cells to restore normal metabolism and Physiological function, its effect is better than that of the positive control drug bifendate within a certain concentration range, indicating that the total triterpenoids of Pteridocarpus have a certain protective effect on chronic alcoholic liver injury.

The invention relates to a medicinal composition for sobering and a relevant preparation process. The preparation process comprises the following steps of: performing microwave extraction on kudzuvine root, flos puerariae, chrysanthemum, linearstripe rabdosia herb, gardenia root, semen hoveniae and fructus amomi which serve as raw material from Chinese medicinal herbs which are homologous in medicines and food, filtering, performing the microwave extracting again, evaporating, concentrating and drying to obtain a sample. The medicinal composition has a certain sobering function, and can resist acute alcoholic liver injury, chronic alcoholism and lipid peroxidation of livers, kidneys and brains of mice, reduce the level of triglyceride, prevent the formation of fatty liver and protect livers.

The invention relates to the medical field, and discloses a liver-protecting composite. The raw materials comprise one of S-ademetionine, cysteine or methionine, vitamin C, flower of kudzuvine, hovenia dulcis thumb and rhizoma alismatis. The invention also provides a preparation method of the liver-protecting composite. The liver-protecting composite is taken after drinking, thus being capable ofpreventing chronic alcoholism and alcoholic cirrhosis; and the liver-protecting composite can be taken for a long term as a liver-protecting health care product, thus having wide application prospects.

The invention belongs to the field of alcoholism relieving beverage, in particular to Chinese medicinal alcoholism relieving health-care beverage with high safety, high drug effect, stable and consistent quality control and acute and chronic alcoholism resistance, and a preparation method thereof. The beverage is prepared from the following raw materials in part by weight: 0.1 to 2 parts of pueraria flavonoid powder, 0.1 to 1.5 parts of bamboo flavonoid powder, 0.1 to 1.5 parts of semen hoveniae extract powder, 0.05 to 0.2 part of silymarin powder, 1 to 4 parts of gastrodia elata powder, 1 to6 parts of fig powder, 0.1 to 1 part of algin powder, 0.01 to 0.2 part of menthol powder, 0.008 to 0.2 part of astaxanthin powder, 15 to 30 parts of resistant starch, and 69.8 to 184.8 parts of purified water. The Chinese medicinal alcoholism relieving health-care beverage has the advantages of mild medicinal property, delicious taste, pure nature and safety, definite content of effective ingredients and quick and remarkable drug effect, stable and consistent quality control and long term administration.

The invention discloses a traditional Chinese medicine composition used for chronic alcoholism. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10-15 parts of flos pueraria omeiensis, 10-15 parts of poria cocos, 5-10 parts of fructus amomi rotundus, 10-15 parts of rhizoma alismatis, 5-10 parts of fructus amomi, and 5-10 parts of medicated leaven. During preparation, the raw materials are prepared into a traditional Chinese medicine potion or pill. The traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, is safe and free from toxic and side effects, can be used for treating polydipsia or chronic alcoholism due to excessive drinking, and is remarkable in effect.

The invention discloses a one-step synthesis method of medicinal metadoxine. The method comprises the steps that vitamin B6 is adopted as a starting raw material and directly reacts with L-pyroglutamic acid after alkali dissociation to obtain metadoxine through one-step synthesis. The proper solvent, the reaction raw material ratio and the proper reaction temperature are adopted, the medicinal metadoxine with the stable crystal form, the good flowability and high purity can be produced industrially without recrystallization or purification, the preparation steps are simplified, operation is easy, the solvent usage amount is decreased, and the production cost is saved. The medicinal metadoxine can be used for treating acute and chronic alcoholism and alcoholic liver diseases.

The invention provides an application of 5-methyltetrahydrofolate and a composition containing the 5-methyltetrahydrofolate. The 5-methyltetrahydrofolate or the composition containing the same is usedfor treating, relieving or preventing various diseases or symptoms caused by acute alcoholism and chronic alcoholism. The injuries or the diseases caused by the acute alcoholism include headache caused by alcohol drinking, negative emotion or depression caused by alcohol drinking, and the hangover symptom after alcohol drinking. The injuries or the diseases caused by the chronic alcoholism include alcoholic fatty liver, central nervous system (CNS) inflammation and the like.

The invention provides a drug for relieving body injury caused by chronic alcoholic poisoning. The drug comprises an effective ingredient of AOAA (aminooxyacetic acid). Learning and memory ability evaluation is performed on chronic alcoholic poisoned rats and normal rats by use of a Y-type electric maze by establishing a rate chronic alcoholic poisoning model. Experimental results prove that compared with normal control groups, the chronic alcoholic poisoning model group of rats has remarkably reduced learning and memory ability. After AOAA intervention is given, the training times required for rats of a remedy group to learn spatial discrimination are reduced, and difference has statistical significance. Accordingly, AOAA can relieve memory deterioration caused by the chronic alcoholic poisoned rats, improves the learning memory ability and provides a scientific basis for research of chronic alcoholic poisoning injury mechanism and treatment by AOAA.

The invention belongs to the technical field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition with a significant function of sobering up and protecting the liver and a preparation method thereof. The traditional Chinese medicine combination is prepared by decocting Chinese medicine raw materials such as Gansong, Codonopsis pilosula, Chinese yam, Chuanxiong, clove, ginger pinellia, white peony root, lotus pod, gastrodia elata, mustard seed, mung bean, jujube, ginger, and licorice according to a certain weight ratio. It is proved by experiments that the traditional Chinese medicine composition of the present invention can significantly improve the activity of enzymes related to alcohol metabolism and inhibit the expression of inflammatory factors, so as to significantly sober up and protect the liver, and improve the effects of symptoms such as dizziness, nausea, abdominal distension and abdominal pain in acute and chronic alcoholism; On the other hand, the traditional Chinese medicine used in the present invention has a wide range of sources, is green and safe, basically has no toxic and side effects on the body, has a simple preparation method, and is convenient to use, and is very suitable for the prevention and treatment of diseases such as alcoholism and liver injury in clinical practice.