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81 results about "Anti-Obesity Agents" patented technology

Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.

Anti-obesity agents

The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a blood component so as to form a stable covalent bond therewith. The present invention also relates to a conjugate comprising such a compound which is covalently bonded to a blood component. Moreover, the invention also relates to a method of enhancing, in a patient, the anti-obesity activity of a PYY peptide or functional derivative thereof.
Owner:CONJUCHEM

Combination therapy for the treatment of dyslipidemia

The present invention relates to compositions comprising an anti-obesity agent and an anti-dyslipidemic agent useful for the treatment of dyslipidemia, dyslipidemia associated with obesity and dyslipidemia-related disorders. The present invention further relates to methods of treating or preventing obesity, and obesity-related disorders, in a subject in need thereof by administering a composition of the present invention. The present invention further provides for pharmaceutical compositions, medicaments, and kits useful in carrying out these methods.
Owner:MERCK SHARP & DOHME CORP

Combination therapy for the treatment of diabetes

The present invention relates to compositions comprising an anti-obesity agent and an anti-diabetic agent useful for the treatment of diabetes, diabetes associated with obesity and diabetes-related disorders. The present invention further relates to methods of treating or preventing obesity, and obesity-related disorders, in a subject in need thereof by administering a composition of the present invention. The present invention further provides for pharmaceutical compositions, medicaments, and kits useful in carrying out these methods.
Owner:MERCK & CO INC +1

Methods for Treating Obesity Employing an SGLT2 Inhibitor and Compositions Thereof

ActiveUS20080234367A1Promoting and increasing and enhancing glucosuriaBiocideMetabolism disorderSGLT2 InhibitorAnti-Obesity Agents
Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in combination with another anti-obesity agent, is administered to a mammalian subject or patient. In addition, a pharmaceutical composition is provided which comprises an SGLT2 inhibitor, alone or in combination with another anti-obesity agent, and a pharmaceutically acceptable carrier thereof.
Owner:ASTRAZENECA AB

Combination therapy for the treatment of hypertension

The present invention relates to compositions comprising an anti-obesity agent and an anti-hypertensive agent useful for the treatment of hypertension, hypertension associated with obesity, and hypertension-related disorders. The present invention further relates to methods of treating or preventing obesity, and obesity-related disorders, in a subject in need thereof by administering a composition of the present invention. The present invention further provides for pharmaceutical compositions, medicaments, and kits useful in carrying out these methods.
Owner:MERCK & CO INC

Combination therapeutic compositions and method of use

The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I selected from one or more of betaines, lipidic betaines, betaine lipids and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, .alpha.-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.
Owner:MESSADEK JALLAL

Combination Therapy for the Treatment of Obesity

The present invention relates to compositions comprising PYY, PYY3-36, or a PYY agonist, and an anti-obesity agent, useful for the treatment and prevention of obesity and obesity-related disorders. The present invention further relates to methods of treating or preventing obesity and obesity-related disorder in a subject in need thereof by administering a composition of the present invention. The present invention further provides for pharmaceutical compositions, medicaments, and kits useful in carrying out these methods.
Owner:MERCK SHARP & DOHME CORP

Combination therapy for the treatment of obesity

The present invention relates to compositions comprising calcium and / or xanthan gum and an anti-obesity agent, useful for the treatment and prevention of diabetes, obesity and obesity-related disorders. The present invention further relates to methods of treating or preventing obesity and obesity-related disorder in a subject in need thereof by administering a composition of the present invention. The present invention further provides for pharmaceutical compositions, medicaments, and kits useful in carrying out these methods.
Owner:MACNEIL TANYA +1

Beta3 adrenergic receptor agonists and uses thereof

The instant invention provides β3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, wherein Ar, R, R1, R2, R3, R4, R5, R6, R7, R8, X, and Y, are as defined herein. The invention further provides intermediates useful in the preparation of the compounds of Formula (I), to combinations of the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, with anti-obesity agents; to pharmaceutical compositions comprising the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, or pharmaceutical compositions comprising the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, and anti-obesity agents; and methods of treating β3 adrenergic receptor-mediated diseases, conditions, or disorders in a mammal which methods comprise administering to the mammal an effective amount of a compound of Formula (I), a stereoisomer or prodrug thereof, or a pharmaceutical composition thereof; or a combination of a compound of Formula (I), a pharmaceutically acceptable salt of the compound, stereoisomer, or prodrug, and an anti-obesity agent, or a pharmaceutical composition thereof.
Owner:PFIZER INC

Combination therapy for the treatment of obesity

The present invention relates to compositions comprising a NPY5 antagonist of formula I or II and an anti-obesity agent, useful for the treatment and prevention of diabetes, obesity and obesity-related disorders. The present invention further relates to methods of treating or preventing obesity and obesity-related disorder in a subject in need thereof by administering a composition of the present invention. The present invention further provides for pharmaceutical compositions, medicaments, and kits useful in carrying out these methods.
Owner:MERCK & CO INC +1

Combination of Organic Compounds

The invention relates to a combination, such as a combined preparation or a pharmaceutical composition, respectively comprisinga renin inhibitor, or a pharmaceutically acceptable salt thereof, andat least one therapeutic agent selected from the group consisting of(a) a specific anti-dyslipidemic agent and(b) a specific anti-obesity agentor, in each case, a pharmaceutically acceptable salt thereof.
Owner:WEBB RANDY LEE

Method for selectively inhibiting reuptake of serotonin and norepinephrine using yeast extract

InactiveUS20060140974A1Reduce premenstrual syndromes (PMSSlow downBiocideMicroorganismsAnti-Anxiety AgentsAnti stress
A yeast extract or yeast-derived bioactive peptide having an activity of selectively inhibiting reuptake of serotonin and norepinephrine, which can be effectively used in preventing or treating various diseases related to reuptake of serotonin and norepinephrine, especially depression, anxiety, stress, fatigue and obesity are provided. Also, a yeast extract or yeast-derived bioactive peptide having activities as an anti-stress agent, an anti-fatigue agent, premenstrual syndrome (PMS) and menstrual pain relaxants, and a brain-neurotrophic factor, and a method for preparing the bioactive peptide are provided. The yeast extract or yeast-derived bioactive peptide is effective in relieving stress, nervousness, anxiety, tension, insomnia, fatigue, and imbalance in the autonomic nerve regulation. Therefore, the yeast extract or yeast-derived bioactive peptide is vailable as an anti-depression agent, an anti-anxiety agent, an anti-stress agent, an anti-fatigue agent, an anti-obesity agent, premenstrual syndrome and menstrual pain relaxants, a bain-neurotrophin, and a source of active foods having these activities.
Owner:LEE MOON SUP +1

Compositions and Methods For the Treatment Of Obesity and Sexual Dysfunction

InactiveUS20080200376A1Relieve nauseaReducing emesis side effectBiocidePeptide/protein ingredientsSexual dysfunctionAgonist
The present invention relates to methods of treating and preventing obesity and obesity-related disorders in a subject comprising administering a neurokinin-1 antagonist and an anti-obesity agent, such as a melanocortin 4 receptor agonist, to said subject. The present invention further related to methods of treating or preventing sexual dysfunction, including male erectile dysfunction, in a subject comprising administering a neurokinin-1 antagonist and a sexual dysfunction therapeutic agent, such as a melanocortin 4 receptor agonist, to said subject. The present invention further provides for pharmaceutical compositions and medicaments useful in carrying out these methods.
Owner:MERCK & CO INC

Anti-obesity agent and use thereof

Disclosed is a novel anti-obesity agent. Also disclosed is a therapeutic method using the anti-obesity agent. The anti-obesity agent comprises a GABAB receptor agonist or a pharmacologically acceptable salt thereof as an active ingredient.
Owner:NAGOYA UNIVERSITY

Diacylethylenediamine compound

Disclosed is a compound useful as an anti-obesity agent. Studies have been made on compounds which have a DGAT1 inhibitory activity and are therefore promising active ingredients for pharmaceutical compositions for treating obesity, type-II diabetes, fatty liver and diseases associated with the aforementioned diseases, and it is confirmed that a specific diacylethylenediamine compound has an excellent DGAT1 inhibitory activity. The diacylethylenediamine compound has a DGAT1 inhibitory activity and can be used as a prophylactic and / or therapeutic agent for obesity, type-II diabetes, fatty liver and diseases associated with the aforementioned diseases.
Owner:ASTELLAS PHARMA INC

Anti-angiogenic agents and Anti-obesity substances applied with Anti-angiogenesis from natural products

Disclosed herein are an anti-obesity agent from natural products based on angiogenesis inhibitory actions, and an angiogenesis inhibitor or a composition for inhibiting obesity, containing at least one selected from the group consisting of Psoraleae Semen extract, Siegesbeckiae Herba extract, and Corni Fructus extract. Because the Psoraleae Semen extract, Siegesbeckiae Herba extract, and Corni Fructus extract of the present invention exhibit angiogenesis inhibitory effects and obesity inhibitory effects, they may be usefully used as an agent for prevention and treatment of angiogenesis-related diseases or obesity.
Owner:IND FOUND OF CHONNAM NAT UNIV

Methods and compositions for controlling body weight and appetite

InactiveUS20070225351A1Good for weight lossDecrease body fatBiocideOrganic chemistryVenous stasisPulmonary artery embolism
The present invention provides novel compositions and methods for the controlling appetite and weight and / or treating obesity using a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound. The invention also provides novel compositions and methods for treating or preventing disorders related to or complicated by excessive body weight or obesity, including coronary heart disease, osteoarthritis, osteoporosis, dislipidemias, gout, atherosclerosis, joint pain, sexual and fertility problems, respiratory problems, gall bladder disease, skin conditions, hypertension, diabetes, stroke, pulmonary embolism, sleep apnea, idiopathic intracranial hypertension, lower extremity venous stasis disease, gastro-esophageal reflux, urinary stress incontinence, metabolic syndrome, insulin resistance and cancer. The methods and compositions of the invention may employ a (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or related compound alone, or in combination with a second anti-appetite or anti-obesity agent.
Owner:DOV PHARMA +1

Combination therapeutic compositions and methods of use

The present invention provides pharmaceutical compositions and methods for the treatment of diabetes mellitus using combination therapy. The compositions relate to a compound of Formula I and an antidiabetic agent such as sulfonylureas, biguanides, glitazones, α-glucosidase inhibitors, potassium channel antagonists, aldose reductase inhibitors, glucagon antagonists, activators of RXR, insulin therapy or other anti-obesity agent. The methods include the administration of the combination of compound of Formula I with antidiabetic agent where the two components are delivered in a simultaneous manner, where the compound of Formula I is administered first, followed by the antidiabetic agent, as well as wherein the antidiabetic agent is delivered first followed by the compound of Formula I.
Owner:AMGEN INC

Face beautifying and body building herb tea

The present invention relates to a face beautifying and body building herb tea, which comprises, by weight, 0.5-1.5 parts of rose, 0.2-0.6 part of lemongrass, 0.2-0.6 part of conmon verbena herb, 0.2-0.6 part of rose hips, 0.2-0.6 part of baked barley tea, and 0.2-0.6 part of globeamaranth flower. After being infused, the herb tea has characteristics of yellowish tea soup, fresh and fragrant taste, mellow taste, and unique aroma of lemongrass and baked barley tea. In addition, the subacid and sweet taste of the yellow face beautifying and body building herb tea is charming, and the herb tea is the beautifying and face nourishing product, has functions of weight reduction and body building, especially provides significant effects for people with fat waist, abdomen and leg and people with greasy diet, can not cause palpitation, insomnia and menstrual disorders, and does not generate any harm on human body, wherein anti-obesity agents containing chemical components can cause palpitation, insomnia and menstrual disorders, and the herb tea is completely prepared from the plants, such that no rebound phenomenon can be generated after taking the herb tea.
Owner:TIANJIN FUHUITANG SCI & TECH

Methods for treating obesity employing an SGLT2 inhibitor

Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in combination with another anti-obesity agent, is administered to a mammalian subject or patient. In addition, a pharmaceutical composition is provided which comprises an SGLT2 inhibitor, alone or in combination with another anti-obesity agent, and a pharmaceutically acceptable carrier thereof.
Owner:ASTRAZENECA AB

Anti-obesity agent

InactiveUS20060210659A1Preventing and treating lifestyle diseasesBiocideConfectioneryGlycosideTriterpene
The object of the present invention is to provide an active substance which has an anti-obesity effect such as a triglyceride lowering activity, a cholesterol lowering activity and the like. The present invention provides a blood triglyceride lowering agent, a cholesterol lowering agent, a body fat storage suppressive agent, an anti-obesity agent and an antilipemic agent, characterized in that each of said agents comprises a cycloartane-type triterpene or glycoside thereof. Moreover, the present invention provides the use of a Black cohosh plant in order to prepare said agents. Further, the present invention provides a beverage, food and quasi-drug comprising said agents.
Owner:ASAHI BREWERIES LTD

Anti-obesity agent, Anti-obesity food or beverage, glucose tolerance-ameliorating agent, and food or beverage for amelioration of glucose tolerance

An anti-obesity agent or a glucose tolerance-ameliorating agent containing a bacterium belonging to the genus Bifidobacterium as an active ingredient, wherein the bacterium belonging to the genus Bifidobacterium exhibits a conversion rate from linoleic acid into conjugated linoleic acid of not more than 10%. The present invention is able to provide an anti-obesity agent and a glucose tolerance-ameliorating agent that are effective for the prevention or treatment of obesity or the amelioration of glucose tolerance and also exhibit superior safety, as well as providing foods or beverages containing these agents. Further, the present invention is also able to provide a bacterium of the genus Bifidobacterium, and in particular a Bifidobacterium breve, that is effective for the prevention or treatment of obesity or the amelioration of glucose tolerance and also exhibits superior safety, as well as providing a pharmaceutical composition containing this bacterium.
Owner:MORINAGA MILK IND CO LTD

Anti-obesity agent and Anti-obesity food

An anti-obesity agent containing, as an active ingredient, a microorganism which belongs to the species Lactobacillus reuteri and is capable of producing lipases having the amino acid sequences respectively depicted in SEQ ID NO: 1, 3 or 5 or amino acid sequences having deletion, substitution or addition of one or more amino acids in the amino acid sequences respectively depicted in SEQ ID NO: 1, 3 or 5. The anti-obesity agent enables a patient to take a normal meal yet preventing the absorption of a fat into the body which is the primary cause of obesity.
Owner:SCHOOL CORP AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTION +1

Formulations and methods for treatment of metabolic syndrome

Formulations and methods of providing an orally-active anti-metabolic disease Fixed Dose Combinations (FDC) for use as personalized medicine to treat different components of the Metabolic Syndrome or Insulin resistance syndrome such as Type II diabetes, Hypertension, Hyperlipidemia and Obesity are disclosed. Pharmaceutical compositions of anti-inflammatory and pancreatic beta-cell centric drug formulations and methods comprising of NSAIDS in general and selective Cox-2 inhibitors in particular and one or more anti-T2DM or anti-hypertensive or anti-hyperlipidemic or anti-obesity drugs formulated to exhibit pre-determined modified release kinetics to achieve therapeutic as well as kinetic synergies are disclosed.
Owner:ARKAY THERAPEUTICS

Glucagon derivatives with improved stability

The present invention relates to a novel glucagon derivative peptide, and a composition for preventing or treating hypoglycemia containing the novel glucagon derivative peptide as an active ingredient. The glucagon derivative according to the present invention has improved physical properties due to the change in isoelectric point (pI) while being capable of maintaining an activity on glucagon receptors, and thus can improve patient compliance when used as a hypoglycemic agent, and is also suitable for administration in combination with other anti-obesity agents. Accordingly, the glucagon derivative according to the present invention can be effectively used for the prevention and treatment of hypoglycemia and obesity.
Owner:HANMI PHARMA
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