90 results about "Airway resistance" patented technology

Method and apparatus for controlling a ventilator are described. The invention can be used to control mechanical ventilators as well as respiratory assist devices such as CPAP machines. The apparatus receives input data indicative of patient's oxygen level. A controller determines PEEP, or CPAP, and FIO2, on the basis of data indicative of the patient's oxygen level. In an alternative embodiment, the apparatus further receives input data indicative of patient's carbon dioxide levels, respiratory elastance and airway resistance, and barometric pressure. The controller further utilizes the said input data to determine the optimal values of tidal volume and breathing frequency for a next breath of the patient, and uses the respiratory elastance and airway resistance data to determine any necessary adjustments in the I:E ratio. The controller also applies safety rules, detects and corrects artifacts, and generates warning signals when needed.

Method and apparatus for controlling a ventilator are described. The invention can be used to control mechanical ventilators as well as respiratory assist devices such as CPAP machines. The apparatus receives input data indicative of patient's oxygen level. A controller determines PEEP, or CPAP, and FIO2, on the basis of data indicative of the patient's oxygen level. In an alternative embodiment, the apparatus further receives input data indicative of patient's carbon dioxide levels, respiratory elastance and airway resistance, and barometric pressure. The controller further utilizes the said input data to determine the optimal values of tidal volume and breathing frequency for a next breath of the patient, and uses the respiratory elastance and airway resistance data to determine any necessary adjustments in the I:E ratio. The controller also applies safety rules, detects and corrects artifacts, and generates warning signals when needed.

Airway monitoring apparatus 30 includes a driver 6 for applying sound in the audible frequency range to the airway of a subject and a detector 7 for monitoring the response of the airway, e.g. by detecting transmitted sound signal components and / or reflected sound signal components. Variations in the detected sound signal, e.g. energy, due to attenuation of the signal, give an indication of the state of the airway, e.g. airway patency, and can be used to monitor sleep-disordered breathing events, such as apnea and hypopnea, and to provide a breathing event index, e.g. AHI. The apparatus may provide servo-control for a respiratory assist device, such as a positive airway pressure device, so as to provide an appropriate pressure level setting. It may allow for home use of such devices and for home titration. It may also assist in discriminating central and obstructive breathing events, and in providing a measure of airway resistance.

A pulmonary treatment system includes a compact configuration for delivery to a first airway of a patient. An energy delivery system of the pulmonary treatment system delivers energy to target tissue in or along an airway wall of the first airway to reduce airway resistance in a second airway distal to the first airway. The pulmonary treatment system protects tissue in the airway wall of the first airway located between the target tissue and the energy delivery system by at least one of thermodynamically cooling, circulating a liquid coolant through the pulmonary treatment system, and shielding a portion of the energy delivery system.

Airway monitoring apparatus 30 includes a driver 6 for applying sound in the audible frequency range to the airway of a subject and a detector 7 for monitoring the response of the airway, e.g. by detecting transmitted sound signal components and / or reflected sound signal components. Variations in the detected sound signal, e.g. energy, due to attenuation of the signal, give an indication of the state of the airway, e.g. airway patency, and can be used to monitor sleep-disordered breathing events, such as apnea and hypopnea, and to provide a breathing event index, e.g. AHI. The apparatus may provide servo-control for a respiratory assist device, such as a positive airway pressure device, so as to provide an appropriate pressure level setting. It may allow for home use of such devices and for home titration. It may also assist in discriminating central and obstructive breathing events, and in providing a measure of airway resistance.

A breathing assistance device is provides guidance to the rescuer, guidance to the victim, and modifies treatment parameters automatically based upon feedback loops relating to patient needs. Guidance can include pictograms showing cartoons of lung expansion, airway patency, breathing rate, and depth of breathing. A microprocessor preferably produces the pictorial guidance as a function of at least one of estimated end tidal CO2, estimated fractional inspired oxygen, estimated fractional expired oxygen, estimated airway resistance, and estimated lung compliance. The microprocessor can also execute a software code that executes a feedback loop that attempts to normalize values of a parameter over time, by controlling at least one pressure in a neck pillow, mask pressure, breathing rate, breathing volume, inspiration time, and expiration time. Contemplated parameters can include estimated end tidal CO2, estimated fractional inspired oxygen, estimated fractional expired oxygen, estimated airway resistance, and estimated lung compliance.

The invention discloses a ventilator and pressure control method, comprising a casing, a turbine fan, a control device, a sensor, and a power supply device; wherein, the turbine fan is used for producing and outputting wind with certain pressure; the control device is connected with the turbine fan to control the operation of the turbine fan; the sensor is positioned at the pressure output end of the turbine fan; wherein, the feedback end of the sensor is connected with the control device; the power supply device is connected with each part for power supply; which is characterized in that: the pressure / flow rate is detected by the sensor, so that the control device can control the turbine fan according to the feedback of the sensor, and the ventilator can provide different output pressure when the user is under different breathing condition; by monitoring the resistance in the air passage during the sleeping process of the user, pressure can be raised according to need, so that the user will not feel uncomfortable. The ventilator has the advantages of simple structure, flexibility of regulating output pressure and ensured application effect.

The present invention concerns a method for determining optimised parameters for mechanical ventilation, MV, of a subject, comprising: a) obtaining data concerning a three-dimensional image of the subject's respiratory system; b) calculating a specific three-dimensional structural model of the subject's lung structure from the image data obtained in step a); c) calculating a specific three-dimensional structural model of the subject's airway structure from the image data obtained in step a); d) calculating a patient-specific three-dimensional structural model of the subject's lobar structure from the lung model obtained in step b); e) modeling by a computer, the air flow through the airway, using the models of the airway and lobar structure of the subject obtained in steps c) and d) at defined MV parameters; f) modeling by a computer, the structural behavior of the airway and the interaction with the flow, using the models of the airway and lobar structure of the subject obtained in steps b) and c) at defined MV parameters; g) determining the MV parameters which lead to a decrease in airway resistance and hence an increase in lobar mass flow for the same driving pressures according to the model of step d), thereby obtaining optimized MV parameters. It also relates to a method for assessing the efficacy of a treatment for a respiratory condition.

A pulmonary treatment system includes a compact configuration for delivery to an airway of a patient. An energy delivery system of the pulmonary treatment system delivers ultrasound energy to target nerve tissue in or along an airway wall of the airway radially outward from surface tissue to reduce airway resistance in a downstream airway. The pulmonary treatment system may protect tissue in the airway wall of the airway located between the target nerve tissue and the ultrasound energy delivery system by a coolant system that may also act as a coupling fluid for the emitted ultrasound energy.

The invention belongs to the technical field of biomedical materials, and relates to application of curcumin solid lipid nano-particles. After traditional Chinese medicament curcumin is loaded with solid nano-lipisome, the syringeability of curcumin can be improved, the bioavailability of curcumin can be improved by about 30 times, and the lung targeting of curcumin can be improved. The SLN-curcumin can be used for effectively treating asthma to recover the airway resistance to a normal level, is safe, does not have remarkable toxic or side effect, and has great market developing potentials. The reaction system related in the invention is relatively stable, the technical operation is simple, the product treatment is especially convenient and convenient, and industrialization can be favored.

A method for measuring lung collapse and for providing information regarding recruitment and successfulness of actions taken to recruit the lung is provided. Alveolar- and proximal pressures are determined at different lung pressures or volumes. Patient airway resistance is calculated combining these measurements with flow measurement. Plotting the resistance against the lung pressure or volume gives a within-breath distribution of the resistance. Increase of this resistance at end-expiration volume or pressure indicates lung collapse.

The present invention provides methods to protect a subject from a respiratory disorder involving an airway obstructive disease such as asthma or chronic obstructive pulmonary disease. Provided are methods to protect a subject from an airway obstructive disease using gene therapy. Methods are provided for supplying FoxA2 function to cells of the lung and airway, such as smooth muscle and epithelial cells, by FoxA2 gene therapy. The FoxA2 gene, a modified FoxA2 gene, or a part of the gene may be introduced into the cell in a vector such that the gene remains extrachromosomal or may be integrated into the subjects chromosomal DNA for expression. These methods provide for administering to a subject in need of such treatment a therapeutically effective amount of a FoxA2 gene, or pharmaceutically acceptable composition thereof, for overexpressing the FoxA2 gene. Such methods of expressing the administered FoxA2 gene in the lungs and airway provide for: (1) preventing or alleving bronchial hyperresponsiveness; (2) preventing or alleving of an airway obstructive disease, e.g., bronchial hyperreactivity, airway hyperresponsiveness, asthma or chronic obstructive pulmonary disorder (“COPD”); (3) reducing the airway resistance response to inhaled natural or synthetic bronchoconstrictors or allergens or to exercise; and (4) enhancing responsiveness (relaxation) of airway tissues to β-agonists.

A device for separating between the upper and lower jaws is disclosed. The device comprises at least one substantially U-shaped rib and a deformable member associated therewith such that said member gradually changes its shape when a pressure is applied on the at least one rib by the jaws. The device is suitable for preventing self-inflicting or externally inflicted injury or for suppressing upper airway resistance syndrome, sleep apnea syndrome or snoring. By filling at least one reservoir formed in the deformable member with a beneficial or edible material and inserting the device into the oral cavity of a subject such that said deformable member separates an upper set of posterior teeth from a corresponding lower set of posterior teeth, the beneficial or edible material may be delivered to the subject.

Two programs measure upper airway resistance using Resistance=Pressure / Flow. Raw flow and pressure data is divided into breaths and time adjusted so each breath starts with the value zero. Each breath is graphed as flow in the y-axis and time in the x-axis. The slope between points Flow=0 and Flow=0.20 is calculated. The resistance is the inverse of the slope. The second program determines whether a breath is flow limited or not. It also uses the flow and time data to perform a curve fitting to describe the flow-time in meaningful polynomial function F (P)=A t3+B t2+Ct+D. The derivative of this function is F′=3At2+2Bt+C. If the value of the derivative F′ at maximum flow is less than or equal zero, then it is a flow limited breath, otherwise, it is non flow limited breath. Also, the need for a pressure-monitoring catheter is obviated.

The invention discloses a pulmonary function test system and method based on an expiration mathematic model, and the method comprises the steps that the system reads an expiration curve of a forced vital capacity test of a testee; a data processing module of the system carries out the data processing of the forced expiration curve, and an output module of the system outputs pulmonary function index parameters; The forced expiration curve just need to meet a test quality control standard, except an expiration end standard, suggested by American Thoracic Society or European Medical Association,and the force expiration time is longer than 3 seconds. The pulmonary function index parameters mainly comprise forced lung capacity, pulmonary drive pressure, airway resistance, forced vital capacityin the first second, and the forced expiratory volume in one second / forced vital capacity (FEVl / FVC). The system and method solve a problem that the quality of the pulmonary function test is low because the expiration in the pulmonary function test is ended too early, achieve the accurate estimation and diagnosis of airway congestion and the barrier limiting degree.

The invention discloses a medical ventilator and a method of continuously measuring airway resistance and compliance for the medical ventilator. The medical ventilator comprises a pressure control device, the pressure control device is provided with an air source input port, an air flow control port and an air flow output port, and the air flow output port is connected with an air flow sensor and a pressure sensor that measures airway pressure of a patient; the medical ventilator employs an airway positive pressure ventilation mode, a high-frequency oscillatory pressure with adjustable amplitude, frequency and duration is added to the pressure level of the airway positive pressure ventilation mode, airway resistance and lung compliance of the respiratory system are measured through the high-frequency oscillatory pressure and flow, the airway resistance and the lung compliance are continuously monitored, and the medical ventilator and the method are used to measure respiratory resistance and compliance at the premise of not interfering normal respiratory cycle of a patient and provide continuous monitoring for the respiratory resistance and compliance. The medical ventilator and the method will help a doctor to set parameters of a mechanical ventilator such that ventilation state of a patient is adjusted in time and ventilation therapeutic efficiency of the ventilator is improved.

The invention relates to an S-(carboxymethyl)-L-cysteine ammonium salt water crystalline pharmaceutical compound (having the following structural formula) and a preparation method and the application of the compound in the preparation of medicines for eliminating phlegm as well as medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases (COPD) and the like. After the compound is adopted, the COPD model rat airway resistance is remarkably reduced, the generation of oxide is reduced, the antioxidant level is increased, and the damage of oxide, inflammatory mediator and the like to the lung can be relieved.

A method of estimating the upper airway resistance of a patient using a gas delivery system includes delivering a flow of breathing gas to the patient through the patient circuit of the gas delivery system, superimposing an oscillatory pressure on the flow of breathing gas during an expiratory phase of the patient, determining a first amplitude of an oscillatory component of a gas pressure provided to the patient at an end of the expiratory phase, determining a second amplitude of an oscillatory component of a gas flow provided to the patient at the end of the expiratory phase, determining a first resistance value based on the ratio of the first amplitude to the second amplitude, and determining an upper airway resistance value based on the first resistance value.

The present invention relates to a composition for preventing or treating respiratory diseases, and more particularly, to a pharmaceutical composition, and to a health food, comprising extracts of herbal mixtures or fermented products thereof having lactic acid bacteria as effective ingredients for preventing or treating respiratory diseases, wherein the herbal mixtures comprise: Sophora flavascens, Radix glycyrrhizae, Flos Lonicerae, Angelicae Gigantis radix, Aralia continentalis, Inula helenium, Saposhnikoviae radix, Zizyphus spinosa, Houttuynia cordata, Forsythiae fructus, Arctium lappa, Herba epimedii, ginseng, Lithospermi radix, Sanguisorbae radix, Cnidii rhizoma, Scrophulariae radix, and Polygoni cuspidati radix. The herbal extracts or fermented products thereof having lactic acid bacteria exhibit the effects of significantly lowering an airway resistance value; reducing the numbers of leukocytes, neutrophilic leukocytes, lymphocytes, eosinocytes, and basophil leukocytes to levels similar to that of a normal group; and reducing the infiltration of inflammatory cells and eosinocyte cells near AHR on lung tissues. Therefore, the herbal extracts or fermented products thereof having lactic acid bacteria may be valuably used for the prevention and / or treatment of respiratory diseases such as asthma.

The invention relates to a device for detecting the pulmonary function of creatures and a using method of the device. The device comprises a plethysmograph box, an animal breathing mask, an airflow shunt component and an oral flow velocity component, wherein the plethysmograph box is used for arranging an animal. The device further comprises a chest pressure measuring component and a tidal volume measuring component. The device can measure various indications of the pulmonary function including chest pressure, oral flow velocity, tidal volume, lung compliance and airway resistance, and the function of atomized application can be realized. The device for detecting the pulmonary function of the creatures is low in cost and convenient to operate, and the detected pulmonary indications can reflect actual conditions of the animal.

A pulmonary treatment system includes a compact configuration for delivery to a first airway of a patient. An energy delivery system of the pulmonary treatment system delivers energy to target tissue in or along an airway wall of the first airway to reduce airway resistance in a second airway distal to the first airway. The pulmonary treatment system protects tissue in the airway wall of the first airway located between the target tissue and the energy delivery system by at least one of thermodynamically cooling, circulating a liquid coolant through the pulmonary treatment system, and shielding a portion of the energy delivery system.

The invention relates to an S-(carboxymethyl)-cysteine pharmaceutical compound and a preparation method and the usage of the compound; the structural formula of the compound is shown by (I); and the compound is especially applied to the preparation of medicines for eliminating phlegm as well as medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases (COPD) and the like. After the compound is adopted, the COPD model rat airway resistance is remarkably reduced, the generation of oxide is reduced, the antioxidant level is increased, and the damage of oxide, inflammatory mediator and the like to the lung can be relieved.

A two-chamber air tube pipe for monitoring blood oxygen saturate through airway without hurt, relates to monitoring device for blood oxygen saturate of mixed vain (Sv02) especially. A main set bag is established on the pipe, and a vice set bag on the left pipe. A oxygen saturate detector is fixed in both of the main and the vice set bags, and connects the oxygen saturate monitor through the conductors buried in the inner pipe wall of the pipe. Oxygen saturate detector is fixed in air tube together with the air tube pipe. Oxygen saturate detector on the surface of the main set bag is directed to main artery, and oxygen saturate detector on the surface of the vice set bag is directed to left pulmonary artery, measuring the blood oxygen saturate of artery (Sa02) and vain (Sv02) individually, and the signal is conducted to the blood oxygen saturate monitor through the conductors. Oxygen saturate detector is fixed in the air tube pipe directly, and the conductors are buried in the pipe walls, which could decrease the impact to diameter and sectional area of air tube pipes, induce the resistance of the air way, and avoid the extra additive damage as a result of the monitoring process.

The invention discloses a nasal resistance testing device and method, and relates to the technical field of medical equipment. An airway connection device is connected with a respiratory flow detection device and a pressure detection device separately, the pressure detection device is connected with a data processing device, and the nasal resistance testing device is used for detecting nose ventilation conditions when people breathe. By putting a ventilation pipe C into a mouth of a patient, bilateral nasal resistance can be tested through nasal respiration; by putting the ventilation pipe C into the mouth of the patient and using a nose plug to plug one nasal cavity, the nasal resistance of the other nose cavity can be tested; and by connecting the ventilation pipe C with the nose plug and putting the nose plug into one nose cavity, the patient closes the mouth, and the nasal resistance of the other nose cavity can be tested. Pressure sensors are used for measuring a pressure difference value of anterior and posterior nasal cavities and a pressure difference value of the two sides of a respiratory flow sensor, the respiratory flow sensor is used for measuring a respiratory flow value, and the nasal resistance is calculated by utilizing related airway resistance algorithms. The nasal resistance testing device is simple in structure, convenient to use and easy to disinfect and needs few consumables.

The invention provides a respirator pressure control method and system. The method includes the following steps: aerating a respirator according to preset airway resistance and preset compliance so as to respectively measure multiple airway flow rates and multiple airway pressures, wherein the airway flow rates are in one-to-one correspondence to the airway pressures; calculating airway resistance and airway compliance of each aeration according to each airway flow rate and each airway pressure; calculating average airway resistance and average airway compliance of the respirator according to the multiple airway resistances and the multiple airway compliances acquired for each aeration; controlling flow rate of aeration according to the average airway resistance and average airway compliance so as to control pressure of the respirator. According to the method, the flow rate of aeration is controlled according to the average airway resistance and the average compliance of the respirator so as to control the pressure of the respirator, so that regulation time is shortened, and performance of the respirator is improved.

The invention discloses a volumetric ventilation control method and system for a turbo ventilator, and the method comprises the steps: 1) calculating a target flow velocity according to a target tidal volume and total inspiration time, and calculating a target pressure according to airway resistance and a lung compliance value in combination with the target flow velocity; 2) calculating a turbine output pressure value in real time according to the target pressure within the total air suction time, and conducting calculating to obtain a turbine rotating speed in combination with the target flow speed; and (3) conducting proportional differential integral control according to the deviation value of the flow velocity value monitored in real time and the target flow velocity, adjusting the rotating speed of the turbine by adjusting the driving voltage of the turbine, and thereby keeping the constant flow velocity. According to the ventilation control method, a method in the prior art that a proportional valve is needed for adjusting the flow speed is effectively improved, the gas circuit structure is simplified, the ventilation performance and control precision of the turbine are improved, the turbine controls the ventilation effect accurately and reliably through actual ventilation use on the breathing machine, and the good effect is achieved.

Described are compositions and methods for the treatment, prevention, or amelioration of a symptom of an airway disorder. In certain aspects, the airway disorder may be one characterized by one or more conditions, such as goblet cell metaplasia, lung tissue inflammation, increased airway hyperresponsiveness, mucus hyperplasia, decreased airway resistance, and increased production of pro-inflammatory cytokines. The compositions and methods may be useful for the treatment of an airway disorder such as asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), allergic disorders, pulmonary inflammatory diseases, pulmonary fibrosis, and / or interstitial lung diseases.