The present invention relates to the technical field of medical devices, in particular to a multi-band laser comprehensive treatment instrument, comprising: a power supply unit, a voltage conversion unit, a signal control unit, an orientation control unit, a constant current drive unit, a laser output unit and a constant temperature control unit. The power supply unit is respectively connected with the voltage conversion unit, the constant current drive unit, the orientation control unit and the constant temperature control unit. The voltage conversion unit is connected with the signal control unit. The signal control unit is respectively connected with the constant current drive unit, the orientation control unit and the constant temperature control unit. The constant current drive unit is connected with the laser output unit. At least two lasers are arranged in the laser output unit, and different lasers emit laser light with different wavelengths. In the multi-band laser comprehensive therapeutic apparatus provided by the present invention, each laser device can emit laser light with different wavelengths, so that the multi-band laser comprehensive therapeutic apparatus can better meet the needs of treatment. In addition, the position and direction of the laser output unit can be adjusted as required, so as to facilitate the treatment of different affected parts.