The invention provides a topological optimization method based on a Matlab and CFX combined solving platform. The topological optimization method mainly includes (1), calling a CFX solver to perform fluid simulation calculation automatically by the Matlab; (2), setting up a dynamic link library to enable an application program to call functions not belonging to executable codes, solving the problem that the Fortran program cannot be recognized by the CFX directly and ensuring that source item information can be transferred to the CFX smoothly; (3), by the Matlab, calling a CFX postprocessing module to export calculation results in a specific format and from a specific patch, reading the calculation results and performing follow-up calculation. The topological optimization method has the advantages that two common softwares, the Matlab and the CFX, are combined together, the Matlab is used for topological optimization algorithm control, the CFX is used for flow field solving, an interface is set up, and the combined solving platform is established, so that mutual calling and data transfer between the Matlab and the CFX are achieved; the advantages of the two softwares are utilized,and optimization solving time can be shortened remarkably while multi-objective optimization can be realized.