The invention discloses a single-core low-speed two-wheeled picomouse sprint controller, comprising an STM32F4 controller, an L6207D chip, a cell, a first sensor, a second sensor, a third sensor, a fourth sensor, a gyroscope, a first motor, a second motor, a third motor, a current sensor and a vacuum apparatus. The STM32F4 controller and the L6207D chip are in signal connection; the signal emission direction of two sensors is the same with a wheel running direction, and the signal emission direction of the other two sensors and the wheel running direction form a certain angle; the gyroscope and the STM32F4 controller are in signal emission; two motors among the three motors are respectively in corresponding connection with two wheels of a two-wheeled picomouse, and the other motor is in connection with the vacuum apparatus. The controller increases an operation speed, constantly monitors and calculates running states of the picomouse, automatically regulates the ground adsorption capability of the vacuum apparatus, and completely avoids the skidding of the picomouse when sprinting with a high speed in a complex labyrinth.