The invention relates to the technical field of pesticide application equipment and discloses automatic granary pesticide application equipment for preventing lying down, the automatic pesticide application equipment comprises a main substrate, a transmission mechanism, a pesticide application mechanism and a PLC control module are arranged on the main substrate, the transmission mechanism comprises drum-shaped walking wheels, the drum-shaped walking wheels are driven by a servo motor, and the servo motor is electrically connected with the PLC control module; wherein a supporting frame is erected on the main substrate, a storage cylinder is fixedly arranged on the supporting frame, a pesticide spraying pipe is communicated with the bottom end of the storage cylinder, a pesticide spraying nozzle is communicated with the end, away from the storage cylinder, of the pesticide spraying pipe, a high-pressure fan is further arranged on the main substrate, an air outlet of the high-pressure fan is communicated with the pesticide spraying pipe through a guide pipe, and the high-pressure fan is electrically connected with the PLC module. The automatic pesticide application equipment is equipment walking in grains, is good in pesticide application effect and high in pesticide application efficiency, the labor cost is reduced, and the equipment is effectively prevented from lying down.