55results about How to "Meet the requirements of GMP" patented technology

The invention belongs to the technical field of medicines and relates to a method for preparing theophylline sustained release. The method comprises the following preparation steps: (1) adding a retardant into a wet type granulator, adding a solvent of the retardant to prepare an adhesive, and stirring and shearing at normal temperature; (2) adding theophylline, an adhesive and a filler and preparing a soft material; (3) replacing a 16-20-mesh stainless steel mesh in the granulator, and granulating through the granulator; and (4) pumping the wet granules into a fluidized bed for drying in a vacuum mode, granulating through a crushing granulator, mixing and laminating to obtain the theophylline sustained release by adding a lubricating agent. The theophylline sustained release can be released at a constant speed, the quality is stable, the pain of the asthmatic is safely, effectively and stably solved, the pain of a patient is relieved, the process is simple, and the process stability is high.

Disclosed are an on-line monitoring type tube centrifuge and a separation technology thereof. The separation technology includes adjusting various materials through a control system, then monitoring the surface of a rotor drum to send a signal to a control system with a microprocessor, leading to the separation under the stated temperature, and sending the separation simultaneously to the automatic control of a control display screen; during the separation, subjecting the materials to entering the rotor drum in the high-speed revolution through a feed pipe to perform the separation, causing liquid to return through a discharging outlet of a liquid accumulating plate, and solid to descend at the bottom of the rotor drum, and discharging the rotor drum to pour the solid. Compared with the prior art, the on-line monitoring type tube centrifuge and the separation technology thereof have the advantages that temperature is measured in the non-contact manner, the temperature is set before the separation, and parameters are adjusted during the separation to achieve timely control; automation degree is high, operation is convenient, the temperature of the materials in the centrifuge is timely controlled, and the like, and accordingly, the material quality is accurately controlled; the separation is displayed on the display screen and a printer through the microprocessor in the visual and convenient manner, and GMP (good manufacturing practice) requirements are met.

The invention relates to continuous-type processing equipment integrating high-temperature sterilization and water-bath cooling, and belongs to the field of manufacturing of high-temperature high-pressure sterilization machines in the industries of food, canned and bottled food, sausages, flexible package food, flexible package drinks, flexible package medicines and the like. The equipment is mainly formed by a bagging device, a material conveying chain, a fed material sealing device, a sterilization chamber, a double-layer load conveying device, a high-temperature water supplying and recycling system, a cooling water supplying and recycling system, a discharged material sealing device and a bag discharging device in a combined mode. When a to-be-processed article enters the sterilization chamber, the equipment is gradually heated and then carries out sterilization processing, warm water which undergoes sterilization processing in a pot can also be used as water compensating a boiler, cooled water can be recycled through a cooling water tower in a cooled mode, and the equipment saves energy, is environmentally friendly, low in energy consumption and fully-automatic, reduces a large amount of heavy manual work, greatly improves production efficiency and has high application performance and reliability.

The invention belongs to the pharmaceutical field, and relates to a drug carrier and a preparation method of the drug carrier, specificly to pharmaceutical pellet cores and a preparation method of the pellet cores. The preparation method provided by the invention comprises the following steps: 1) sieving fine granulated sugar; 2) preparing a suspension by dissolving hydroxypropyl methylcellulose in water and stirring to dissolve; adding starch and the milled fine granulated sugar powder, stirring evenly and sieving; 3) preparing pellet cores in one step by placing sieved fine granulated sugarfrom step 1) in a fluidized bed, starting side spray process of the fluidized bed and adjusting the rotary speed, starting spray and adjusting the spray speed, drying after spray of the mixed suspension of sugar and starch is completed and discharging; and 4) sieving and packaging the dried pellet cores.

The invention discloses a weighing clamping mechanism which comprises a rack. The weighing clamping mechanism is characterized in that a positioning rod is arranged in the rack, the left end of the positioning rod and the right end of the positioning rod are provided with a first synchronous belt wheel and a second belt synchronous wheel respectively, the first synchronous belt wheel and the second belt synchronous wheel are connected through synchronous belts, and the right end of the positioning rod is exposed out of the right side of the rack. A guide holder is arranged at the upper portion of the left side of the rack, a linear motor is arranged on each synchronous belt wheel, the bottom end of the linear motor is connected with each synchronous belt wheel through a shaft assembly, the top end of the linear motor is connected with the bottom end of a guide rod through a coupler, the top end of the guide rod is exposed out of the guide holder, and a clamping assembly is arranged on the top end of the guide rod. A speed reducer is arranged on each second synchronous belt wheel, the speed reducer is connected with the synchronous belt wheel through transmission shafts, and a servo motor is arranged on the speed reducer. The servo motor passes through the speed reducer, and drives the clamping assembly to rotate through a synchronous belt transmission mechanism. The linear motor drives the clamping assembly to move in a lifting mode through the guide rod. An air cylinder drives a bottle clamp to achieve opening or closing of the bottle clamp, and three kinds of motion are combined in order to achieve the functions of clamping, transporting and releasing.

An on-off valve for time-pressure dispensing and cip-sip, comprising a valve core disposed in a valve body; a seal ring is provided between the valve core and the valve body, and the valve core fits with the valve body. The on-off valve has good sealing effect and a simple structure, and is easy to disassemble and operate.