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Preparation method of licorice particles for livestock and poultry

A technology of licorice and granules, which can be applied to medical preparations with no active ingredients, medical preparations containing active ingredients, and devices for making medicines into special physical or ingestible forms. There are many problems such as loss of components and prolonging the extraction time, so as to save power energy, facilitate leaching, and increase the amount of feeding

Active Publication Date: 2012-10-17
ZHENGZHOU BARY ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the commonly used preparation methods of licorice granules include traditional water-alcohol extraction method and wet granulation method, which have many disadvantages, such as large loss of active ingredients, low content, difficult operation of post-production process, long production cycle, serious pollution in the production process, and violation of GMP requirements, etc.
Patent No. CN101474244A discloses a formula granule of roasted licorice and its preparation method and quality control method, which provides a good quality control method, but in the process of pre-production, the method of second decoction is still equivalent to the traditional The unique decoction extraction method prolongs the extraction time and cumbersome operating procedures

Method used

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  • Preparation method of licorice particles for livestock and poultry
  • Preparation method of licorice particles for livestock and poultry

Examples

Experimental program
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Effect test

Embodiment 1

[0018] The licorice granules for livestock and poultry in this example are prepared from 100 parts of licorice, 20 parts of anhydrous glucose, and 60 parts of maltodextrin as the main raw materials. The specific preparation method is as follows:

[0019] 1) Take 100 parts of licorice, clean them, chop them and place them in an extraction tank to form a medicinal material layer, add water 8 times the weight of licorice to cover the medicinal material layer and soak for 2 hours, then adjust the working temperature of the extraction tank to 60°C for extraction. During the process, part of the extract is extracted from the bottom of the extraction tank for concentration under reduced pressure. The concentration temperature is 50°C. The steam generated by the concentration is condensed and returned to the extraction tank as a new solvent for percolation and extraction of the medicinal material layer. This is repeated for 2 hours, and finally Concentrate to obtain a liquid extract wi...

Embodiment 2

[0024] The licorice granules for livestock and poultry in this example are prepared from 120 parts of licorice, 25 parts of anhydrous glucose, and 70 parts of maltodextrin as main raw materials. The specific preparation method is as follows:

[0025] 1) Take 120 parts of licorice, clean them, chop them and place them in an extraction tank to form a medicinal material layer, add water 9 times the weight of licorice to cover the medicinal material layer and soak for 1.5 hours, then adjust the working temperature of the extraction tank to 70°C for extraction. During the process, part of the extract is extracted from the bottom of the extraction tank for concentration under reduced pressure. The concentration temperature is 60°C. The steam generated by the concentration is condensed and returned to the extraction tank as a new solvent for percolation and extraction of the medicinal material layer. This is repeated for 2.5 hours, and finally Concentrate to obtain a liquid extract wi...

Embodiment 3

[0030] The licorice granules for livestock and poultry in this example are prepared from 150 parts of licorice, 10 parts of anhydrous glucose, and 50 parts of cyclodextrin as main raw materials. The specific preparation method is as follows:

[0031] 1) Take 120 parts of licorice, clean them, chop them and place them in an extraction tank to form a medicinal material layer, add water 10 times the weight of licorice to cover the medicinal material layer and soak for 2.5 hours, then adjust the working temperature of the extraction tank to 80°C for extraction. During the process, part of the extract is extracted from the bottom of the extraction tank for concentration under reduced pressure. The concentration temperature is 70°C. The steam generated by the concentration is condensed and returned to the extraction tank as a new solvent for percolation and extraction of the medicinal material layer. This is repeated for 3 hours, and finally Concentrate to obtain a liquid extract wit...

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Abstract

The invention discloses a preparation method of licorice particles for livestock and poultry, comprising the following steps of: firstly taking licorice, placing it into an extraction pot to form a medicinal material layer, adding water and immersing, adjusting the operating temperature of the extraction pot to 60-80 DEG C for extraction, leading out parts of an extract from the bottom of the extraction pot during the extraction process and carrying out vacuum concentration while the concentration temperature is 50-70 DEG C, condensing steam generated by the concentration, returning the stream used as a new solvent into the extraction pot for permeating extraction of the medicinal material layer, continuously repeating for 2-3 hours, condensing to finally obtain a fluid extract, adding anhydrous glucose and maltodextrin or cyclodextrin and the fluid extract into a spray drying granulator, and carrying out granulation so as to obtain the licorice particles for livestock and poultry. According to the preparation method of the licorice particles for livestock and poultry, the two processes of licorice extraction and condensation are synchronously carried out so as to change a high-temperature decocting technology of a traditional extraction pot under pressure and at normal pressure. Therefore, energy can be saved by 0.3-0.5 time; the amount of a hydrosolvent is minimized by 0.5-1 time; the feeding amount is increased by 30-60%; extract yielding rate is raised by more than 10%; the storage process is minimized; and electric power energy is saved by more than 30%.

Description

technical field [0001] The invention relates to a preparation method of licorice granules for livestock and poultry, and belongs to the technical field of veterinary medicine. Background technique [0002] Traditional Chinese medicine granule (granula) is a new dosage form developed on the basis of decoction and syrup. It not only maintains the characteristics of fast absorption and rapid action of decoction, but also overcomes the inconvenience of decoction and large dosage. It is very suitable for clinical drug administration in modern and intensive farms. It has the advantages of good palatability, small dosage, rapid drug effect, controllable quality, good stability, and convenient storage, transportation and carrying. [0003] Licorice granule is a single pure traditional Chinese medicine preparation for livestock and poultry. It has the functions of eliminating phlegm, relieving cough, anti-inflammation and detoxification. It has a significant effect on respiratory di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K47/40A61K47/36A61K47/26A61K9/16A61P31/04A61P31/12A61P11/00A61P1/14A61P31/22A61P31/14A61J3/00
Inventor 郭玉凡王佳伟杨晶张宁张旭
Owner ZHENGZHOU BARY ANIMAL PHARMA
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