The invention discloses a pre-emphasis drive circuit based on a cascade pseudo-differential structure. The drive circuit comprises a biasing circuit, a first MOS transistor, a second MOS transistor, athird MOS transistor, a fourth MOS transistor, a fifth MOS transistor, a sixth MOS transistor, a seventh MOS transistor, an eighth MOS transistor, a ninth MOS transistor, a tenth MOS transistor, an eleventh MOS transistor and a twelfth MOS transistor, wherein all the first MOS transistor, the second MOS transistor, the third MOS transistor, the seventh MOS transistor, the eighth MOS transistor and the ninth MOS transistor are P-type MOS transistors; all the fourth MOS transistor, the fifth MOS transistor, the sixth MOS transistor, the tenth MOS transistor, the eleventh MOS transistor and thetwelfth MOS transistor are N-type MOS transistors. The drive circuit provided by the invention has the advantages that output flexibility is high on the basis of a simple circuit structure, differentpre-emphasis voltage drive signals can be output as needed, and different environment requirements are met.