The invention discloses an oral cavity medicine applying device which comprises an elliptical fixed ring. A transparent silica gel sheet is fixedly connected on the inner side of the fixed ring, an inserting opening is formed in the transparent silica gel sheet, an injection pipe is inserted into the inserting opening, an injection head is arranged at one end of the injection pipe, a piston is slidably and hermetically connected in the injection pipe, a piston rod is fixed on one side, far away from the injection head, of the piston, one end, far away from the piston, of the piston rod penetrates the end of the injection pipe and is fixedly connected with a pushing plate, a plurality of fixed seats are equidistantly arranged on one side, close to the pushing plate, of the fixed ring, supporting rods are rotatably connected on the fixed seats, and clamping rods are arranged on two sides of one end, far away from the corresponding fixed seat, of each supporting rod. According to the device, the injection pipe is conveniently adjusted and fixed and cannot be affected by shake of hands of medical staff in the injection process, and a syringe is prevented from directly contacting with an affected part, so that secondary injury to a patient is avoided.