31results about How to "Influence stability" patented technology

The present invention relates to a liposome combination, which wrapped hydrophilic drugs in water layer and wrapped hydrophobic drugs in lipid bilayer; hydrophobic drugs are photosensitizers. Using light with appropriate wavelength to activate the photosensitizer in the hydrophobic layer can result in the production of singlet oxygen and the free radical, and cause the oxidizing and breaking of the carbon chain of the phospholipid, and influences the stability of the liposome and the releases of the drug. The singlet oxygen and the free radical will attack the cancer cells at the same time as a result of combining the photodynamic- and chemo-effects.

One arrangement in combination, a bone implant, and one or more bioactive substances which can reduce inflammation in implant surgery, preferably in the field of dentistry. The implant may also comprise one or more bioactive substance(s) that can promote osseointegration of said bone implant. At least one of said one or more bioactive substances may be capable of reducing proliferation, differentiation, and / or activity of osteoclasts, stimulating proliferation of osteoblasts, and / or reducing inflammation.

Disclosed herein is an insulinotropic peptide multi-dose aqueous parenteral pharmaceutical composition and use thereof. A long-term storage formulation of the insulinotropic peptide can be obtained via the method of the present disclosure. The pharmaceutical composition of the present disclosure comprises: insulinotropic peptide, insulinotropic peptide analogue and derivative; pharmaceutically acceptable tonicity modifier (stabilizer); pharmaceutically acceptable preservative; and pharmaceutically acceptable dissolution enhancer and pharmaceutically acceptable buffer solution. The pharmaceutical composition of the insulinotropic peptide is used in the preparation of drugs for treating diabetes and adiposis.

A graphene oxide-ceramic hybrid coating layer formed from a graphene oxide-ceramic hybrid sol solution that includes graphene oxide (GO) and a ceramic sol and a method of preparing the coating layer are provided. A content of graphene oxide in the graphene oxide-ceramic hybrid coating layer is about 0.002 to about 3.0 wt % based on the total weight of the graphene oxide-ceramic hybrid coating layer.

The invention relates to a lockable ejector device for a furniture part that is movably supported in a piece of furniture, including a fixing device for locking the movable furniture part in place in a closed end position, and at least one ejector element for moving the movable furniture part from the closed end position into an open position, wherein the fixing device comprises at least two locking units, which are coupled to each other and each have a receiving element for an engagement element. The at least two locking units are operatively connected to each other by way of a synchronization mechanism, which has at least two coupling elements, each associated with different locking units, and at least one synchronization unit. The coupling elements are coupled by way of the synchronization unit with respect to the movements thereof.

A yokeless stator for an axial flux machine, comprising a housing, the housing comprising a circumferential portion and a plurality of elongated portions extending radially inwards therefrom, and a plurality of discrete stator teeth arranged within the circumferential portion, each discrete stator tooth comprising a ferromagnetic material and an electrical winding; the housing further comprising an electrically isolating filling material filling empty space inside the housing. The circumferential portion of the housing is made of a first non-ferromagnetic material and the elongated portions are made of a second non-ferromagnetic material. The housing comprises a laminated structure, which comprises at least part of the plurality of inwardly directed elongated portions.

A heat dissipation module for removing heat from a heat-generating electronic component includes a base (106) and a clip (40, 40a). The clip includes a connecting arm (42, 42a) and a securing arm (44, 44a) for locking the base to the heat-generating electronic component. The connecting arm engages with the base. The securing arm extends from the contacting arm and is curve-shaped with a free end thereof being for being depressed whereby the securing arm exerts a downward force on the base so that the base and the electronic component can have an intimate contact with each other.

To provide a resin composition comprising an aromatic polycarbonate resin and having excellent appearance, impact strength, thermal stability, hydrolysis resistance, and flame retardancy.The present invention relates to a resin composition comprising (A) 75 to 99.98 wt % of an aromatic polycarbonate resin (component A), (B) 0.01 to 5 wt % of a mixture of polytetrafluoroethylene particles and an organic polymer (component B) and (C) 0.01 to 20 wt % of a flame retardant (component C), wherein the sodium metal ion content of the component B (excluding sodium metal ion contained in the polytetrafluoroethylene particles) is 10 ppm or less, and molded articles therefrom.

A vehicle seat includes a backrest and a seat part, at least one of which has a structural element with a cavity. The cavity is formed by a base plate and at least two profiles secured to the base plate. A corner region of the two profiles has provided in it a filling configured to influence the stability and / or the deformation behavior of the backrest and / or the seat part. The filling has a foam support and a foam material at least partially surrounding the foam support.

Medical syringe having a gasket excellent in sealability and slidability. The syringe includes a hollow cylindrical syringe barrel (11) and a gasket (13) fitted in syringe barrel (11). Gasket (13) includes a main body of an elastic material laminated with an inert resin film and has a circumferential surface portion (17) substantially maintained in contact with an inner surface (16) of syringe barrel (11). Gasket 13 also has an annular projection (22), provided on circumferential surface portion (17), extending circumferentially of circumferential surface portion (17). Projection (22) has a contact surface portion maintained in contact with inner surface (16) of syringe barrel (11) and having a width of 30 μm to 40 μm. Circumferential surface portion (17) has non-contact surface portions located out of contact with inner surface (16) of syringe barrel (11) on widthwise opposite sides of projection (22) and having a width of at least 30 μm.

In order to realize a cost-effective production of a transponder in an RFID system that is intended for the identification of merchandise, the invention proposes a two-part housing with an upper housing part and a lower housing part, wherein the lower housing part is provided with a grounding surface and an antenna with a transponder IC is spaced apart from and arranged above this grounding surface.

A robotic system includes a robot adapted for moving a payload in proportional response to an input force from an operator, sensors adapted for measuring a predetermined set of operator input values, including the input force, and a controller. The controller determines a changing stiffness value of the operator using set of operator input values, and automatically adjusts a level of control sensitivity over the robot using the stiffness value. The input values include the input force, a muscle activation level of the operator, and a position of the operator. A method of controlling the robot includes measuring the operator input values using the plurality of sensors, processing the input values using the controller to thereby calculate the stiffness value, and automatically adjusting the level of control sensitivity over the robot using the stiffness value. A specific operator may be identified, with control sensitivity being adjusted based on the identity.

A robotic system includes a robot adapted for moving a payload in proportional response to an input force from an operator, sensors adapted for measuring a predetermined set of operator input values, including the input force, and a controller. The controller determines a changing stiffness value of the operator using set of operator input values, and automatically adjusts a level of control sensitivity over the robot using the stiffness value. The input values include the input force, a muscle activation level of the operator, and a position of the operator. A method of controlling the robot includes measuring the operator input values using the plurality of sensors, processing the input values using the controller to thereby calculate the stiffness value, and automatically adjusting the level of control sensitivity over the robot using the stiffness value. A specific operator may be identified, with control sensitivity being adjusted based on the identity.

The present application relates to a pregabalin sustained release composition, comprising: (a) an active ingredient; (b) a matrix-forming agent; (c) a swelling agent; (d) a gelling agent; and optionally a filler. The pregabalin sustained release composition provided in the present application can rapidly swell in volume when exposed to aqueous medium until exceeding the diameter of human gastric pyloric (13 mm). It thereby prolongs the gastric emptying time to increase the retention time of pregabalin in the stomach and enhances absorption of pregabalin in the small intestine and ascending colon. Moreover, the pregabalin sustained release composition provided herein achieves a sustained release for 24 h, which allows QD (once a day) administration, reduces administration number, and improves patient compliance.

Laminated gasket free from liquid drug leakage. A gasket (13) for a medical syringe, with main body (14) made of elastic material, and film (15) provided on a surface of main body (14). Gasket (13) has a circumferential surface portion (17) for contact with an inner peripheral surface of a syringe barrel (11) and an annular groove (22) formed circumferentially in a surface portion of the film in the circumferential surface portion thereof. Annular groove (22) has outer edge portions (24) provided along opposite edges (23) thereof as projecting from an unprocessed surface portion of the film. Annular groove (22) has a groove formation start point and a groove formation end point connected to each other in a groove connection region. Outer edge portions (24) provided along the opposite edges of the annular groove have a maximum-to-minimum height difference of ≤5 μm in the groove connection region.

Laminated gasket free from liquid drug leakage. Gasket (13) to be used for a medical syringe includes main body (14) made of an elastic material and film (15) on a surface of main body (14). Gasket (13) has a circumferential surface portion (17) that can contact an inner peripheral surface of syringe barrel (11) of the syringe, and has an annular groove (22) formed circumferentially in a surface portion of the film present in the circumferential surface portion thereof. Annular groove (22) has outer edge portions (24) provided along opposite edges (23) thereof as projecting from an unprocessed surface portion of the film. Annular groove (22) has groove formation start points and end points that are connected to each other in a groove connection region. Outer edge portions (24) along the opposite edges of the annular groove have a maximum-to-minimum height difference of ≤5 μm in the groove connection region.

A graphene oxide-ceramic hybrid coating layer formed from a graphene oxide-ceramic hybrid sol solution that includes graphene oxide (GO) and a ceramic sol and a method of preparing the coating layer are provided. A content of graphene oxide in the graphene oxide-ceramic hybrid coating layer is about 0.002 to about 3.0 wt % based on the total weight of the graphene oxide-ceramic hybrid coating layer.

Medical syringe having a gasket excellent in sealability and slidability. The syringe includes a hollow cylindrical syringe barrel (11) and a gasket (13) fitted in syringe barrel (11). Gasket (13) includes a main body of an elastic material laminated with an inert resin film and has a circumferential surface portion (17) substantially maintained in contact with an inner surface (16) of syringe barrel (11). Gasket 13 also has an annular projection (22), provided on circumferential surface portion (17), extending circumferentially of circumferential surface portion (17). Projection (22) has a contact surface portion maintained in contact with inner surface (16) of syringe barrel (11) and having a width of 30 μm to 40 μm. Circumferential surface portion (17) has non-contact surface portions located out of contact with inner surface (16) of syringe barrel (11) on widthwise opposite sides of projection (22) and having a width of at least 30 μm.

The invention is directed to a battery case (1) comprising a compartment (2) for at least one battery module (3). Two first outer beams (4) extending in a first spatial direction (x) and two second outer beams (5) extending in a second spatial direction (y) are arranged essentially perpendicular to the first spatial direction. The first and second beams (4, 5) are forming a frame-like support structure (6). A tub-shaped insert (7) is connected to the grid like support structure (6) from a third direction (z) arranged essentially perpendicular to the first and the second direction (x, y). A closure (8) closes the tub-shaped insert (7) to form the closed compartment (2) for the at least one battery module.

To provide a resin composition comprising an aromatic polycarbonate resin and having excellent appearance, impact strength, thermal stability, hydrolysis resistance, and flame retardancy.The present invention relates to a resin composition comprising (A) 75 to 99.98 wt % of an aromatic polycarbonate resin (component A), (B) 0.01 to 5 wt % of a mixture of polytetrafluoroethylene particles and an organic polymer (component B) and (C) 0.01 to 20 wt % of a flame retardant (component C), wherein the sodium metal ion content of the component B (excluding sodium metal ion contained in the polytetrafluoroethylene particles) is 10 ppm or less, and molded articles therefrom.

This present invention relates to a complex of a glucopyranosyl derivative and L-pyroglutamic acid as a sodium dependent glucose cotransporter (SGLT) inhibitor, and preparation processes thereof, and a pharmaceutical composition containing the complex, and their uses in the manufacture of a medicament for treating diabetes and / or diabetes-related diseases.

In a conventional laminated gasket production method, when a product of a laminated gasket is demolded from a mold, the product is rubbed against the mold and, therefore, minute scratches are formed on a surface of the laminated gasket. These minute scratches are liable to prevent reliable sealing of a liquid drug. The present invention is a method for producing a gasket to be used for a medical syringe and is characterized by including the steps of: preparing a gasket molding mold; molding a gasket having a circumferential surface portion in the mold with the gasket being laminated with a lamination film; and demolding the gasket from the mold, and then forming a groove only in the lamination film circumferentially of the circumferential surface portion of the gasket.

A yokeless stator for an axial flux machine, comprising a housing, the housing comprising a circumferential portion and a plurality of elongated portions extending radially inwards therefrom, and a plurality of discrete stator teeth arranged within the circumferential portion, each discrete stator tooth comprising a ferromagnetic material and an electrical winding; the housing further comprising an electrically isolating filling material filling empty space inside the housing. The circumferential portion of the housing is made of a first non-ferromagnetic material and the elongated portions are made of a second non-ferromagnetic material. The housing comprises a laminated structure, which comprises at least part of the plurality of inwardly directed elongated portions.

This present invention relates to a complex of a glucopyranosyl derivative and L-pyroglutamic acid as a sodium dependent glucose cotransporter (SGLT) inhibitor, and preparation processes thereof, and a pharmaceutical composition containing the complex, and their uses in the manufacture of a medicament for treating diabetes and / or diabetes-related diseases.