31results about How to "Influence stability" patented technology

The present invention relates to a liposome combination, which wrapped hydrophilic drugs in water layer and wrapped hydrophobic drugs in lipid bilayer; hydrophobic drugs are photosensitizers. Using light with appropriate wavelength to activate the photosensitizer in the hydrophobic layer can result in the production of singlet oxygen and the free radical, and cause the oxidizing and breaking of the carbon chain of the phospholipid, and influences the stability of the liposome and the releases of the drug. The singlet oxygen and the free radical will attack the cancer cells at the same time as a result of combining the photodynamic- and chemo-effects.

Disclosed herein is an insulinotropic peptide multi-dose aqueous parenteral pharmaceutical composition and use thereof. A long-term storage formulation of the insulinotropic peptide can be obtained via the method of the present disclosure. The pharmaceutical composition of the present disclosure comprises: insulinotropic peptide, insulinotropic peptide analogue and derivative; pharmaceutically acceptable tonicity modifier (stabilizer); pharmaceutically acceptable preservative; and pharmaceutically acceptable dissolution enhancer and pharmaceutically acceptable buffer solution. The pharmaceutical composition of the insulinotropic peptide is used in the preparation of drugs for treating diabetes and adiposis.

A graphene oxide-ceramic hybrid coating layer formed from a graphene oxide-ceramic hybrid sol solution that includes graphene oxide (GO) and a ceramic sol and a method of preparing the coating layer are provided. A content of graphene oxide in the graphene oxide-ceramic hybrid coating layer is about 0.002 to about 3.0 wt % based on the total weight of the graphene oxide-ceramic hybrid coating layer.

A bush is adapted to connect a suspension link with a link support member which is one of a wheel support member and a vehicle body member. The bush includes an inner cylinder which extends in a front and rear direction and which is connected with one of the suspension link and the link support member, an outer cylinder which includes an inside circumferential surface confronting an outside circumferential surface of the inner cylinder and which is connected with the other of the suspension link and the link support member, and an elastic member interposed radially between the inner cylinder and the outer cylinder. The inner cylinder is formed with a bulge portion which projects radially outwards from the outside circumferential surface of the inner cylinder at a middle portion of the inner cylinder in an axial direction of the inner cylinder of the link bush.

The invention relates to a lockable ejector device for a furniture part that is movably supported in a piece of furniture, including a fixing device for locking the movable furniture part in place in a closed end position, and at least one ejector element for moving the movable furniture part from the closed end position into an open position, wherein the fixing device comprises at least two locking units, which are coupled to each other and each have a receiving element for an engagement element. The at least two locking units are operatively connected to each other by way of a synchronization mechanism, which has at least two coupling elements, each associated with different locking units, and at least one synchronization unit. The coupling elements are coupled by way of the synchronization unit with respect to the movements thereof.

A heat dissipation module for removing heat from a heat-generating electronic component includes a base (106) and a clip (40, 40a). The clip includes a connecting arm (42, 42a) and a securing arm (44, 44a) for locking the base to the heat-generating electronic component. The connecting arm engages with the base. The securing arm extends from the contacting arm and is curve-shaped with a free end thereof being for being depressed whereby the securing arm exerts a downward force on the base so that the base and the electronic component can have an intimate contact with each other.

A vehicle seat includes a backrest and a seat part, at least one of which has a structural element with a cavity. The cavity is formed by a base plate and at least two profiles secured to the base plate. A corner region of the two profiles has provided in it a filling configured to influence the stability and/or the deformation behavior of the backrest and/or the seat part. The filling has a foam support and a foam material at least partially surrounding the foam support.

Medical syringe having a gasket excellent in sealability and slidability. The syringe includes a hollow cylindrical syringe barrel (11) and a gasket (13) fitted in syringe barrel (11). Gasket (13) includes a main body of an elastic material laminated with an inert resin film and has a circumferential surface portion (17) substantially maintained in contact with an inner surface (16) of syringe barrel (11). Gasket 13 also has an annular projection (22), provided on circumferential surface portion (17), extending circumferentially of circumferential surface portion (17). Projection (22) has a contact surface portion maintained in contact with inner surface (16) of syringe barrel (11) and having a width of 30 μm to 40 μm. Circumferential surface portion (17) has non-contact surface portions located out of contact with inner surface (16) of syringe barrel (11) on widthwise opposite sides of projection (22) and having a width of at least 30 μm.

In order to realize a cost-effective production of a transponder in an RFID system that is intended for the identification of merchandise, the invention proposes a two-part housing with an upper housing part and a lower housing part, wherein the lower housing part is provided with a grounding surface and an antenna with a transponder IC is spaced apart from and arranged above this grounding surface.

A robotic system includes a robot adapted for moving a payload in proportional response to an input force from an operator, sensors adapted for measuring a predetermined set of operator input values, including the input force, and a controller. The controller determines a changing stiffness value of the operator using set of operator input values, and automatically adjusts a level of control sensitivity over the robot using the stiffness value. The input values include the input force, a muscle activation level of the operator, and a position of the operator. A method of controlling the robot includes measuring the operator input values using the plurality of sensors, processing the input values using the controller to thereby calculate the stiffness value, and automatically adjusting the level of control sensitivity over the robot using the stiffness value. A specific operator may be identified, with control sensitivity being adjusted based on the identity.

A laminated gasket (13) to be used for a medical syringe is provided, which includes a main body (14) made of an elastic material, and a film (15) provided on a surface of the main body (14). The gasket (13) has a circumferential surface portion (17) to be brought into contact with an inner peripheral surface (16) of a syringe barrel (11) of the syringe. The gasket (13) further includes a projection (22) provided on a surface portion of the film (15) present in the circumferential surface portion (17) as extending circumferentially of the gasket. The projection (22) has a height of not less than 15 μm and not greater than 55 μm and a width of not less than 30 μm and not greater than 75 μm. With this arrangement, the laminated gasket is excellent in sealability.

This present invention relates to a complex of a glucopyranosyl derivative and L-pyroglutamic acid as a sodium dependent glucose cotransporter (SGLT) inhibitor, and preparation processes thereof, and a pharmaceutical composition containing the complex, and their uses in the manufacture of a medicament for treating diabetes and/or diabetes-related diseases.