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The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded RNA (“dsRNA”), and methods for preparing them, that are capable of reducing the expression of target genes in eukaryotic cells. The dsRNA has a first oligonucleotide sequence that is between 25 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of at least 19 nucleotides is sufficiently complementary to a nucleotide sequence of the RNA produced from the target gene to trigger the destruction of the target RNA by the RNAi machinery.

The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly metastatic cancer and cancers of T cell origin, and hyperproliferative diseases involving EphA2-expressing cells. The methods of the invention entail the use of a Listeria-based EphA2 vaccine. The invention also provides pharmaceutical compositions comprising one or more Listeria-based vaccines of the invention either alone or in combination with one or more other agents useful for cancer therapy. In certain aspects of the invention, the methods entail eliciting both CD4+ and CD8+ T-cell responses against EphA2 and / or EphA2-expressing cells.

The present invention concerns CAR, CAR-T and CAR-NK constructs, preferably comprising a scFv antibody fragment against a disease-associated antigen or a hapten. More preferably, the antigen is a TAA, such as Trop-2. The constructs may be administered to a subject with a disease, such as cancer, autoimmune disease, or immune dysfunction disease, to induce an immune response against disease-associated cells. Where the constructs bind to a hapten, the subject is first treated with a hapten-conjugated antibody that binds to a disease associated antigen. Therapy may be supplemented by other treatments, such as debulking procedures (e.g., surgery, chemotherapy, radiation therapy) or coadministration of other agents. More preferably, administration of the construct is preceded by predosing with an unconjugated antibody that binds to the same disease-associated antigen. Most preferably, an antibody against CD74 or HLA-DR is administered to reduce systemic immunotoxicity induced by the constructs.

The invention relates to a hybrid power unmanned aerial vehicle energy source control method based on power following, belonging to the technical field of hybrid power control of unmanned aerial vehicles. According to the hybrid power unmanned aerial vehicle energy source control method, a solar battery, a fuel battery and a lithium battery are mixed and arranged in an unmanned aerial vehicle power system to form a hybrid power system. Each energy source is controlled by comprehensively considering factors including output properties, conversion efficiency, service life, current state, flight mission profiles, needed power of electronic equipment and the like of each energy source; the self advantages can be expressed to the greatest extent under the condition that the total output power can meet the needed power of flight of the unmanned aerial vehicles and the inner electronic equipment, so that the whole hybrid power system can be at a better state and the unmanned aerial vehicles have longer unmanned aerial vehicle and better power performances.

A method and infrastructure are provided for monitoring and analyzing the storage media quality and the drive hardware performance of a media library. The media library comprises a plurality of removable storage media, a plurality of drive units for said storage media and means for moving said storage media to and from appropriate drive units. The media library is managed by a management system being connected to said media library. At least one reference medium of a known and proven quality to compare the performance of at least one of said storage media in a given drive unit with the performance of said reference medium in said given drive unit and / or to test the performance of at least one given drive unit of said media library when acting on said reference medium.

The invention provides atrial fibrillation signal recognition method, device and equipment, wherein the method comprises: acquiring an electrocardiogram signal to be recognized; inputting the electrocardiogram signal to an atrial fibrillation signal recognition model pre-established, and putting results of atrial fibrillation signal recognition, wherein the atrial fibrillation signal recognition model is established by acquiring a set amount of electrocardiogram sample signals and corresponding identifier information that includes normal signal and atrial fibrillation signal identifier information, using SMOTE (synthetic minority over-sampling technique) to balance atrial fibrillation signals according to the amount of normal signals, establishing a network structure of multiple convolutional neural networks each of which is provided with a specific receptive field for recognizing the atrial fibrillation signal of corresponding granular size, inputting the normal signals and the balanced atrial fibrillation signals to the network structure, and training. The atrial fibrillation signal recognition method, device and equipment can provide improved reliability and accuracy of atrial fibrillation signal recognition.

A case for cooling a portable electronic device, the case including a housing and a cartridge. The housing holds the electronic device and has a cartridge compartment for retaining the cartridge. The cartridge includes sets of compartments for retaining substances configured to generate an endothermic reaction when mixed or combined. Pairs of compartments are separated by a divider configured to be selectively breached. The duration of the cooling effect may be extended by periodically breaching dividers of additional compartment pairs. The magnitude of the cooling effect may be increased by breaching multiple compartment pairs at once. The case may also include electronic components for monitoring the temperature of the electronic device and automatically initiating an endothermic reaction when the temperature reaches a predetermined threshold.

The invention provides a detachable tailstock type vertical take-off and landing unmanned aerial vehicle. Wings and a fuselage can be detachably assembled. The wings and the fuselage can form two overall arrangement forms. According to the X-shaped overall arrangement form, two pairs of wings are mounted on the fuselage and are bilaterally symmetrical, and each pair of wings is of a longitudinal symmetry structure; and the included angle between the wings in each pair is 120 degrees, and the four wings form an X shape. According to the Y-shaped overall arrangement form, three wings are mounted on the fuselage, the included angel between every two adjacent wings is 120 degrees, and the three wings form a Y shape. The unmanned aerial vehicle of the X-shaped overall arrangement form is suitable for long-distance flight under a wind-free condition. The vertical take-off and landing unmanned aerial vehicle of the Y-shaped overall arrangement form is suitable for short-distance flight under a lateral wind condition. According to the detachable tailstock type vertical take-off and landing unmanned aerial vehicle, the structure is simple, and control is easy; and since the wings and the fuselage are connected detachably, the unmanned aerial vehicle is suitable for different occasions, singular problems in a transition mode are avoided, and long endurance and long-distance flight can be achieved.

The invention relates to the technical field of unmanned aerial vehicles, in particular to a hybrid power multi-axis rotor-wing unmanned aerial vehicle. The hybrid power multi-axis rotor-wing unmannedaerial vehicle comprises an unmanned aerial vehicle body which comprises a flight control system and a multi-axis driving system arranged in a case. The hybrid power multi-axis rotor-wing unmanned aerial vehicle is characterized in that the hybrid power multi-axis rotor-wing unmanned aerial vehicle further comprises a fuel and electricity hybrid power system, a servo module and a measuring and controlling module; the fuel and electricity hybrid power system is constituted by a fuel piston engine, a fuel tank, a power generation module, a rectification module and a lithium battery; one end ofthe fuel piston engine is connected with the fuel tank through a fuel pipe, and the other end of the fuel piston engine is connected with the servo module; an output shaft of the fuel piston engine isconnected with the power generation module; the power generation module is connected with one end of the rectification module, and the other end of the rectification module is connected with the lithium battery in parallel and then connected with the multi-axis driving system; and the multi-axis driving system is constituted by a plurality of single-axis drivers. The hybrid power multi-axis rotor-wing unmanned aerial vehicle has the advantages of being long in endurance, large in load, easy to control, good in safety and the like.

The invention aims at providing an oil-drive direct-driven multi-rotor-wing agricultural plant protection unmanned aerial vehicle which can greatly prolong the runtime, is high in structural stability and anti-shock capacity and can increase the load capacity. According to the adopted technical solution, the oil-drive direct-driven multi-rotor-wing agricultural plant protection unmanned aerial vehicle comprises a machine frame, avionics, a power mechanism and a spraying mechanism; the machine frame comprises a supporting beam, an upper central plate, a lower central plate, machine arms and pull rods; the upper central plate and the lower central plate are fixedly connected to the supporting beam; the six machine arms are fixed between the upper central plate and the lower central plate in a crossed mode in the regular hexagon diagonal direction; a reinforced umbrella-shaped structure formed by the pull rods is arranged between the machine arms and the supporting beam; each power unit comprises an engine fixed to an engine base, a steering engine fixed to the bottom of the engine, and a propeller connected to an output shaft of the engine; the power mechanism of an oil-drive direct-driven structure; and the output shafts of the engines are directly connected with the propellers.

The invention relates to a concrete pouring device and a concrete pouring method for an ultrahigh steel pipe concrete column tremie method. Inner baffles are arranged at intervals in a steel pipe. Pouring holes are formed in the middle parts of the inner baffles. Air vents are distributed on the peripheries of the inner baffles. The device comprises a column top movable platform which is connected onto the top of the steel pipe, a guide pipe which is inserted into the steel pipe, and a feeding hopper which is connected onto the upper part of the guide pipe. The column top movable platform consists of a joint steel pipe 5, a main beam, a secondary beam, diagonal bracings, a steel plate and a guardrail. Two clamping plates which can be upwards turned over are connected at the mouth of the top of the joint steel pipe through hinges. Guide pipe clamping mouths which are used for positioning the guide pipe are formed in the middles of the two clamping plates. The bottom of the joint steel pipe is fixedly connected with the steel pipe. The guide pipe is formed by sections in connecting way. The guide pipe is downwards inserted into the steel pipe through the joint steel pipe. The concrete pouring device and the concrete pouring method for the ultrahigh steel pipe concrete column tremie method have the advantages that the one-step pouring height can reach 29m, the requirement on the construction period and process can be met, the concrete column is detected as acceptable through ultrasonic detection, the pouring quality is reliable and the device and the method are particularly suitable for the pouring construction of ultrahigh steel pipe concrete with dense baffle holes.

The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by containing cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell / gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

The invention provides a vehicle-mounted power supply management and control system and equipment for a small-sized unmanned aerial vehicle. The system comprises a power supply switching and power supply management module, a power supply and distribution module, a data acquisition and interface conversion module; the power supply switching and power supply management module is used for realizing rectification and filtration, power supply switching, voltage conversion of a three-phase power supply of a generator and online charging of a backup battery group; the power supply and distribution module is used for realizing power supply and distribution for a self-driving vehicle, a steering engine, an electronic control unit, a short message device, a broadcasting station and an internal control circuit; and the data acquisition and interface conversion module is used for realizing voltage acquisition for the battery group, ECU data framing, electric level conversion from TTL to RS232 and control for a main power supply module and two electrical switching circuits. According to the vehicle-mounted power supply management and control system and equipment for the small-sized unmanned aerial vehicle, the integration degree of the avionics system of the unmanned aerial vehicle is higher; the power supply for the electric generator of the unmanned aerial vehicle is realized; and the flying endurance and the flying reliability are greatly improved.

The invention belongs to the fields of structural design and flight control of a multi-rotor-wing aircraft, and particularly relates to a distributed multi-rotor-wing unmanned aerial vehicle system with a heavy load and long endurance. The distributed multi-rotor-wing unmanned aerial vehicle system comprises an independent fuselage and distributed vehicle bodies, wherein the independent fuselage comprises standard boxes and box arms; each stand box is at least provided with three box arms; the distributed vehicle bodies are fixed on the box arms of the independent fuselage; each of the distributed vehicle bodies comprises a power system, a vehicle arm and an electronic system, wherein the power systems are mounted at the upper ends of the vehicle arms, and the electronic systems are mounted at the lower ends of the vehicle arms; each of the power systems comprises rotor wings, an engine, an oil pump, an oil tank and a steering engine; each of the electronic systems comprises a flight control system and a power supply module. The independent fuselage and the distributed vehicle bodies are designed in a high-modularized way, so that quick matching, disassembling and assembling can be realized; the unmanned aerial vehicle system is convenient to repair, maintain, transport and produce in batches; the power systems adopt direct oil-driving structures, and the engines directly drive the rotor wings, so that the structure is simplified, the weight is reduced, the endurance is greatly prolonged, and the load is enlarged.

The invention discloses a three-axis fluxgate aeromagnetic measurement system based on a vertical take-off and landing aircraft with fixed-wings, and a correction and compensation method therefor. Themethod comprises the steps of: pre-collecting a series of three-axis fluxgate digital output readings generated by the change of the attitude as a numerical input, solving a nonlinear least squares equation set to obtain 12 compensation parameters having a common influence on the three-axis fluxgate magnetometer; and storing the obtained compensation parameters into a multi-data synchronous acquisition and correction compensation system, and performing real-time and post-flight correction compensation on the vector magnetic field and the total field data obtained by the line-measurement of the aeromagnetic flight by using a compensation algorithm. According to the three-axis fluxgate aeromagnetic measurement system and the correction and compensation method therefor, the intensity data ofthe total magnetic field after being corrected is obtained without the need of the optical pump magnetometer, so the three-axis fluxgate aeromagnetic measurement system is suitable for light and small drone platforms. The magnetometer is integrated into the mission compartment of the drone, and the protection is in place, and the disassembly and assembly is convenient. The compensation algorithmused greatly improves the accuracy of the three-axis vector high-precision magnetometer and greatly reduces the noise of the system.

A drug which is preferably usable for inhibiting inflammation in chronic and autoimmune inflammatory processes and / or produces vasodilating and sympathicolytic effects.This use is achieved through a drug from a mixture containing a local anesthetic of the ester type or amide type, preferably procaine hydrochloride, water, and at least one substance for adjusting the pH of the mixture in the range of 7.6 to 8.6. It is possible by this drug to significantly increase the injectable amount of local anesthetic compared with commercially available and known drugs containing a local anesthetic as active ingredient. The mixture can be applied continuously by subcutaneous or intravenous infusion.

The invention relates to a primary and secondary aircraft with wing tips connected in parallel. The primary and secondary aircraft is a high-aspect-ratio subsonic aircraft composed of a primary aircraft (1) and two secondary aircrafts (2) through a connecting mechanism (3), wherein the two secondary aircrafts (2) are symmetrically mounted at two sides of the primary aircraft (1); the primary aircraft (1) is of a high-aspect-ratio subsonic layout form; the two secondary aircrafts (2) are respectively positioned at the left and right wing tips of the primary aircraft (1) and are of a straight wing layout form; and the connecting mechanism (3) is positioned between a primary wing tip (4) and secondary wing tips (5) and is connected with the primary aircraft (1) and the secondary aircraft (2)by adopting a slide rail or a link mechanism. The secondary aircrafts (2) can independently complete corresponding flight missions by virtue of self-power, thereby being favorable for reducing the damage risk of the primary aircraft (1), reducing the using cost and being favorable for improving the using cost-effectiveness ratio of the unmanned aerial vehicle.

The invention provides a small aircraft, comprising an aircraft body (3), an airfoil (11), a horizontal tail (4), a vertical tail (9), a power system part (1) located at the front part of the aircraft body (3), and a propeller (14) located at the front part of the power system (1); the small aircraft is characterized by further comprising a tilting mechanism (2) located at the upper middle part of the aircraft body, wherein the power system (1) is connected with the aircraft in a tiltable manner by the tilting mechanism (2), so that the propeller (14) of the power system (1) can axially tilt correspondingly. The small aircraft further comprises a pitching posture adjusting system arranged at the tail part of the aircraft body and used for controlling the pitching of the aircraft when the aircraft takes off.

The application discloses a wireless sensor management method and device, and a communication system. The communication system comprises a site management unit, a management node, and a wireless sensor; the wireless sensor sends a connection request to a management node in an awakening state; the management node queries whether a first message is cached at local in advance; the first message is the message of the site management unit received by the management node when the wireless sensor is in a dormancy state; the management node sends a response to the wireless sensor according to a queryresult; the response carries the first message when the query result is that the first message is cached at the local in advance; the response indicates that the first message is not cached in the management node when the query result is that the first message is not cached at the local in advance, and the wireless sensor quickly switches to the dormancy state from the awakening state after receiving the response. By implementing the management method disclosed by the application, the battery life of the wireless sensor can be prolonged, and the demand that the wireless sensor is applied to anaccess side site in scale is satisfied.

The present invention relates to the field of image processing technology, especially to a cross laser image roadbed surface settlement monitoring method. The method comprises the steps of: image denoising; image threshold segmentation and morphological processing; coarse positioning of horizontal ordinates of a cross light spot; coarse positioning of longitudinal coordinates of the cross light spot; and obtaining of a coarse positioning center, wherein the coarse positioning center is taken as a center to obtain center coordinates of the image through adoption of a gray centroid method. According to the monitoring method, image denoising, image threshold segmentation and morphological processing are combined to obtain a cross light spot having a smooth edge, and a two-step positioning algorithm with combination of coarse positioning of a cross point of intersection and the local gray centroid method is provided to obtain the accurate positioning center of the image. The algorithm provided by the invention has higher calculation precision and is shorter in time compared to a method of positioning of an elliptic spot through adoption of a gray centroid method.

A sound enhancing device for F-hole stringed instruments, banjos, and drums. The device includes at least one cross-shaped element and a timbre square, which may be part of a larger, user-constructed sound emitter. Strung like beads along a fastener, one or more cross-shaped elements and timbre squares are arrayed between a bridge and terminal retainer. In one embodiment, the cross-shaped element and timbre square are juxtaposed, forming a sound emitter which is mounted within an F-hole instrument's sound chamber; the bridge, positioned above it and astraddle opposing F-hole side edges, collects inaudible sound surface waves and transmits them through the fastener —a knot-free, waxed string under tension—to the sound emitter. There sound waves are amplified by constructive interference, timbre characteristics added, and sound waves transferred into the sound chamber's air. The latter then increase the sound surface waves at the F-hole's edges, setting up a positive feedback loop.

The invention discloses a falling-off mooring-type vertical take-off and landing fixed-wing unmanned aerial vehicle which comprises a fixed-wing structure system, a fixed-wing power system, a rotor-wing power system, a power source system, a flight control system and an onboard avionic system. The power source system comprises a power management module, a lithium battery pack, a fuel tank and a falling-off separated-type electric coupler. The power supplying output end of the falling-off separated-type electric coupler and the lithium battery pack are both connected with the power management module, and a ground power supplying system is connected with the power supplying input end of the falling-off separated-type electric coupler. According to the falling-off mooring-type vertical take-off and landing fixed-wing unmanned aerial vehicle, through the falling-off separated-type electric coupler, in the take-off process of an airplane, a mooring cable is connected with the ground power supplying system, thus power energy needed by the rotor-wing power system is directly supplied, power is sufficient, the needed power of lift-off flight is ensured, the effective load is increased, andthe stability and anti-wind capability in the multi-rotor working process are improved.