31results about How to "Decrease risk" patented technology

A method to optimize CRT therapy using ventricular lead motion analysis, either radiographically or with three dimensional electromagnetic mapping, to determine whether focal dyssynchrony is present at baseline, and whether biventricular pacing improves synchronicity and fractional shortening, and if no improvement is evidenced, changing the timing offset, pacing configuration and / or repositioning the ventricular leads to optimize effectiveness of CRT therapy. Various uses of this method include: diagnostic, with temporary leads to determine presence or absence of dyssynchrony and response to pacing; and therapeutic, to guide lead placement and programming during implant of CRT, and to optimize reprogramming of CRT during follow-up.

Method for bone reinforcement, fixation and treatment of diseased or fractured bones including a supporting structure optionally coated with therapeutic agent is provided. The supporting structure or device used in the method may be collapsible upon deployment at the surgical site, and include fixation features such as anchors to securely position in place once deployed. Bone cement or other material may be provided to alternatively secure the positioned supporting structure for treatment. The disclosed method includes, for example, a method of repairing a bone fracture comprising: accessing a fracture along a length of a bone through a bony protuberance at an access point at an end of a bone; advancing a bone fixation device into a space through the access point at the end of the bone; bending a portion of the bone fixation device along its length to traverse the fracture; and locking the bone fixation device into place within the space of the bone.

The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer. In particular, the invention concerns certain genes, the varied expression of which indicates the likelihood of recurrence of surgically resected breast cancer in patients who are not treated with a therapeutic agent in the adjuvant setting. In addition, the invention concerns the use of quantitative measurement of the expression of certain genes, including the ESR1 gene, that measure as a continuous variable, to determine (a) the likelihood of a beneficial response to the anti-estrogen therapeutic agent, such as tamoxifen; and (b) the potential magnitude of beneficial response to chemotherapy.

The invention provides compositions and methods for determining patient compliance with a smoking cessation program, and monitoring the patient for physiological recovery from the deleterious effects of smoking, with particular emphasis on those effects that impact risk of cardiovascular disease and development of cancer. The invention also provides compositions and methods for treating a subject according to the patient compliance with the smoking cessation program.

An ophthalmological laser system and operating method wherein laser-supported operative interventions can be achieved with higher accuracy. The cornea is irradiated with an ophthalmological laser and a detection light confocally recorded, the cornea being scanned in three-dimensions by irradiation with an illuminating laser power using a scanner unit along several directions at several points. Using the simultaneously recorded detection light the position and / or shape of a posterior boundary surface of the cornea is determined. A lamella parallel to the posterior boundary surface can then be cut.

Patch servers, patch clients and corresponding methods are provided that may increase secret protection and key loss tolerance. A patch server includes a first key generation platform and a second key generation platform different from the first one. A first and second private key group containing a plurality of first or second private keys, respectively, is generated using the first or second key generation platform, respectively. One of the first private keys is selected from the first private key group, and one of the second private keys is selected from the second private key group. A first digital signature is generated based on the patch and the first selected private key. A second digital signature is generated based on the patch and the second selected private key. The patch is transmitted to the patch client together with the first and second digital signatures.

In an example, a method determines one or more characteristics of an intersection of two or more lanes of a roadway and determines a plurality of compatible movement groups representing allowable movement options of vehicles approaching the intersection. The method further calculates delays for the compatible movement groups, respectively, selects a compatible movement group from the plurality of compatible movement groups based on the delays, and provides control instructions to a set of the vehicles in a control region of the intersection associated with the compatible movement group to control one or more dynamics of each of the vehicles of the set as the vehicles of the set traverse the intersection.

An articulating pusher assembly, disposed within a nail loading assembly, includes an articulating pusher coupled to an adapter, the articulating pusher for engaging a nail. The adapter may be further coupled with a casing which engages a spool assembly to provide a constant pressure on the articulating pusher assembly to advance the nail down the length of the nail loading assembly. The articulating pusher is enabled to accommodate the use of a variety of nail types and collation angles of nail strips within the nail loading assembly.

A system and method facilitating review, communication and monitoring of regulatory compliance on a utility or project and in particular a computerized, web-based, environmental compliance system (ECS) which monitors, evaluates and displays environmental compliance (or non-compliance) information for any utility or construction project. This includes receiving, storing, communicating and displaying compliance data and information extending over the life of the project from (a) project development phase, through (b) the construction phase, (c) operation phase, and finally (d) project decommissioning phase.

An improved dual battery power system uses two separate battery power sources for an implantable cardioverter defibrillator, each having optimized characteristics for monitoring functions and for output energy delivery functions, respectively. The monitoring functions are supplied electrical power by a first battery source, such as a conventional pacemaker power source in the form of a lithium iodide battery which is optimized for long life at very low current levels. The output energy delivery functions are supplied by a separate second battery source, such as a pair of lithium vanadium pentoxide batteries, which is optimized for high current drain capability and low self-discharge for long shelf life. The first battery source provides electrical power only to the monitoring functions of the implantable cardioverter defibrillator, and the second battery source provides all of the electrical power for the output energy delivery functions.

An armored protective sport glove for use in historical-type armed combat having an underlying durable flexible glove with extending cuff having rivets and washers. A contoured armored backplate with padded underlayment is attached to the underlying glove, the backplate connecting with underlying material strips which over and along the back of the fingers and thumb providing connections for overlapping finger and thumb plates which flare at the knuckles and wrap exposed portions of the hand and thumb. The contoured overlapping plates and underlying material connection strips connected with one another and to the underlying glove at specific positions allowing for increased mobility and ease of replacement of worn or broken materials. Fingertip protection is increased by use of soft durable connection means decreasing the risk of smashed or pinched fingertips. Pivot points at the wrist increase mobility at the wrist and thumb.

An electrically conductive resistive layer (26) is produced by thermally spraying an electrically conductive material (18) onto the surface of a non-conductive substrate (12). Initially, the material layer (14) arising therefrom has no desired shape. The material layer (14) is then removed (24) in certain areas so that an electrically conductive resistive layer (26) having said desired shape is produced.

A safety illumination device that is mountable to an edge of a ski or snowboard is provided. The device has a curved exterior housing with a front window panel along the convex front portion, an upper window panel along the top and a concave cutout along the rear portion. A circuit board containing control circuitry, a power source and two arrays of lights is housed within the exterior housing. When the device is turned on, light is emitted through the window panels. This assists persons uphill and downhill from the user to see the user in the dark. Selection of an illumination pattern is controlled by a magnetic wand that the user waves over the upper surface of the device. Users may thus easily operate the device and customize their lighting experience. The device is secured to a ski or snowboard via the concave cutout and a pair of screws.

The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometriosis is performed with observing in serum specimens of a patient the concentration and change of the biochemical marker, in particular molecules related to alpha 1-antitrypsin, and comparing with a predetermined baseline level of the biochemical marker contained in serum. Statistical analysis can be performed to evaluate the baseline level indicating the occurrence of endometriosis. Therefore, the present invention can provide an auxiliary guideline for the diagnosis of endometriosis. The present invention also relates to usage of the biochemical marker.

The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.

For transport of granulate from a granulation tank by means of liquid and air, an ejector is provided with a side inlet for granulate, a first end with a spray nozzle for pressurized transport liquid, and a second end with an inlet for pressurized gas. Downstream from the second end, an outlet spray nozzle for a three-phase flow of liquid, granulate, and gas is provided. A first conduit has a lower end connected with the outlet for transport of the three-phase flow. The ejector includes a tubular ejector housing with an internal wear liner and an outlet spray nozzle made from a durable material. The inlet for pressurized gas includes a ring-shaped chamber that surrounds the periphery of the ejector and is connected with the inside of the ejector through a ring-shaped slit that directs the pressurized gas towards the outlet of the ejector.

The present invention includes a system, kit and apparatus to aid in the realignment of one or more bones of a patient. The present invention provides a substantially rigid orthopedic stabilization scaffold for attachment of one or more external fixators for the realignment of one or more bones of a patient. The orthopedic stabilization scaffold includes a first anchorable frame and a second anchorable frame that are removably attachable to an operating table and connected adjustably by one or more crossbars.

The present invention provides methods and markers for characterizing a subject's, particularly a human subject risk of having cardiovascular disease. The present invention also provides methods of characterizing a subject's risk of developing cardiovascular disease. In another embodiment, the present invention provides methods for characterizing a subject's risk of experiencing a complication of cardiovascular disease or major adverse cardiac event within 1, 3, or 10 years. In another embodiment, the present invention provides a method for determining whether a subject presenting with chest pain is at risk near term of experiencing a heart attack or other major adverse cardiac event. The present methods are especially useful for identifying those subjects who are in need of highly aggressive CVD therapies as well as those subjects who require no therapies targeted at inhibiting or preventing CVD or complications of CVD.

The disclosure relates to tube with a tube head (4) and a container (5) made of resilient material, wherein the tube head (4) is connected to the container (5), wherein the tube head (4) comprises a female Luer lock fitting (7) with a flow passage (17), the female Luer lock fitting (7) being designed for sealingly receiving a male Luer lock fitting (9) of a syringe (2), wherein a tamper-evident closure (11; 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting (7) such that it closes the flow passage (17) in a closed state of the tube (1).

A system and method for identifying and responding to exceptional charge events of series-connected energy storage elements.

A method for production of a wine with lower content of alcohol involving treating unfermented grape juice with glucose oxidase and glucose isomerase.

A block, particularly for filtering particulates present in the exhaust gases of an internal combustion engine, includes a plurality of flow channels for the gases (14e,14s), each of the channels (14e,14s) being bounded by a side wall (22), a plug (15e,15s) and an opening (19e,19s) terminating outwardly. The block according to the invention is remarkable in that a first portion (34) of the side wall (22) of at least one of the channels (14p,14p″), called the “reinforced channel”, includes a reinforcement compared to the rest of the side wall (22) forming a second portion (36) of the side wall (22), the ratio (R) of the thickness of the first portion (34) to the thickness of the second portion (36), in any transverse plane of section (P), being between 1.1 and 3.

An immunotherapy useful for treating a cancer and / or treating and preventing a microbial infection is provided. A pharmaceutical composition which comprises a bacterial component as an effective ingredient is disclosed, which is used for immunotherapy in a patient suffering from a cancer or microbial infection, wherein the immunotherapy comprises eradicating the cancer cells or the microorganisms from the lymph nodes of the patient.

This disclosure relates generally to a safety apparatus on a rope, comprising a housing for guiding the rope, a clamping element such as a trigger designed to release and clamp the rope against the housing, and a control element, wherein the control element comprises a rope sensor able to be actuated, which enables movement of the trigger to an active, clamped position thus halting the rope between the trigger and a housing.

Novel processes are disclosed for manufacture of N-(3-(5-(4-chlorophenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (I), wherein no protection-deprotection sequences or halogenation steps are required and use of palladium catalysts is minimized.

The present invention provides, among other things, methods of treating a muscular dystrophy including administering to a subject suffering from or susceptible to a muscular dystrophy an angiotensin (1-7) peptide.

Methods of selecting umbilical cord blood units for ex-vivo expansion, separation of CD133+ / CD34+ positive and uncultured CD133+ / CD34+ negative fractions, methods for expanding the selected CD133+ / CD34+ fraction, selection of expanded populations of CD133+ / CD34+ cord blood cells for transplantation to subjects in need thereof and the therapeutic use of suitable selected, ex-vivo expanded CD133+ / CD34+ and unselected CD133 / CD34 negative cord blood fractions for transplantation in the clinical setting, for treatment of hematological malignancies are provided. The present invention also envisions kits comprising the expanded and unselected cord blood fractions.